PMID- 37427077
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230914
IS  - 2398-385X (Electronic)
IS  - 2398-385X (Linking)
VI  - 8
IP  - 2
DP  - 2023
TI  - A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk.
LID - e230005 [pii]
LID - 10.20900/jpbs.20230005 [doi]
AB  - The risk for developing schizophrenia is increased among first-degree relatives 
      of those with psychotic disorders, but the risk is even higher in those meeting 
      established criteria for clinical high risk (CHR), a clinical construct most 
      often comprising of attenuated psychotic experiences. Conversion to psychosis 
      among CHR youth has been reported to be about 15-35% over three years. Accurately 
      identifying individuals whose psychotic symptoms will worsen would facilitate 
      earlier intervention, but this has been difficult to do using behavior measures 
      alone. Brain-based risk markers have the potential to improve the accuracy of 
      predicting outcomes in CHR youth. This narrative review provides an overview of 
      neuroimaging studies used to investigate psychosis risk, including studies 
      involving structural, functional, and diffusion imaging, functional connectivity, 
      positron emission tomography, arterial spin labeling, magnetic resonance 
      spectroscopy, and multi-modality approaches. We present findings separately in 
      those observed in the CHR state and those associated with psychosis progression 
      or resilience. Finally, we discuss future research directions that could improve 
      clinical care for those at high risk for developing psychotic disorders.
FAU - Mamah, Daniel
AU  - Mamah D
AD  - Department of Psychiatry, Washington University Medical School, St. Louis, MO, 
      63110, USA.
LA  - eng
GR  - R01 MH127571/MH/NIMH NIH HHS/United States
GR  - R21 MH124060/MH/NIMH NIH HHS/United States
GR  - R21 MH131962/MH/NIMH NIH HHS/United States
GR  - U01 MH124639/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20230526
PL  - England
TA  - J Psychiatr Brain Sci
JT  - Journal of psychiatry and brain science
JID - 101739159
PMC - PMC10327607
MID - NIHMS1905873
OTO - NOTNLM
OT  - ASL
OT  - CHR
OT  - MR spectroscopy
OT  - PET
OT  - UHR
OT  - diffusion imaging
OT  - functional connectivity
OT  - high risk
OT  - neuroimaging
OT  - psychosis risk
OT  - schizophrenia risk
OT  - structural
COIS- CONFLICTS OF INTEREST The author declares that he has no conflicts of interest.
EDAT- 2023/07/10 06:42
MHDA- 2023/07/10 06:43
PMCR- 2023/07/07
CRDT- 2023/07/10 05:19
PHST- 2023/07/10 06:43 [medline]
PHST- 2023/07/10 06:42 [pubmed]
PHST- 2023/07/10 05:19 [entrez]
PHST- 2023/07/07 00:00 [pmc-release]
AID - e230005 [pii]
AID - 10.20900/jpbs.20230005 [doi]
PST - ppublish
SO  - J Psychiatr Brain Sci. 2023;8(2):e230005. doi: 10.20900/jpbs.20230005. Epub 2023 
      May 26.