PMID- 37428308
OWN - NLM
STAT- MEDLINE
DCOM- 20230905
LR  - 20240426
IS  - 1573-6768 (Electronic)
IS  - 1389-5729 (Linking)
VI  - 24
IP  - 5
DP  - 2023 Oct
TI  - Molecular mechanism of caloric restriction mimetics-mediated neuroprotection of 
      age-related neurodegenerative diseases: an emerging therapeutic approach.
PG  - 679-708
LID - 10.1007/s10522-023-10045-y [doi]
AB  - Aging-induced neurodegenerative diseases (NDs) are significantly increasing 
      health problem worldwide. It has been well documented that oxidative stress is 
      one of the potential causes of aging and age-related NDs. There are no drugs for 
      the treatment of NDs, therefore there is an immediate necessity for the 
      development of strategies/treatments either to prevent or cure age-related NDs. 
      Caloric restriction (CR) and intermittent fasting have been considered as 
      effective strategies in increasing the healthspan and lifespan, but it is 
      difficult to adhere to these routines strictly, which has led to the development 
      of calorie restriction mimetics (CRMs). CRMs are natural compounds that provide 
      similar molecular and biochemical effects of CR, and activate autophagy process. 
      CRMs have been reported to regulate redox signaling by enhancing the antioxidant 
      defense systems through activation of the Nrf2 pathway, and inhibiting ROS 
      generation through attenuation of mitochondrial dysfunction. Moreover, CRMs also 
      regulate redox-sensitive signaling pathways such as the PI3K/Akt and MAPK 
      pathways to promote neuronal cell survival. Here, we discuss the neuroprotective 
      effects of various CRMs at molecular and cellular levels during aging of the 
      brain. The CRMs are envisaged to become a cornerstone of the pharmaceutical 
      arsenal against aging and age-related pathologies.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Sharma, Apoorv
AU  - Sharma A
AD  - Amity Institute of Neuropsychology and Neurosciences, Amity University Uttar 
      Pradesh, Noida, 201313, India.
FAU - Singh, Abhishek Kumar
AU  - Singh AK
AUID- ORCID: 0000-0002-3186-9898
AD  - Amity Institute of Neuropsychology and Neurosciences, Amity University Uttar 
      Pradesh, Noida, 201313, India. aks84m@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230710
PL  - Netherlands
TA  - Biogerontology
JT  - Biogerontology
JID - 100930043
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
SB  - IM
MH  - Humans
MH  - *Caloric Restriction
MH  - Neuroprotection
MH  - *Neurodegenerative Diseases/prevention & control
MH  - Phosphatidylinositol 3-Kinases
MH  - Aging/metabolism
OTO - NOTNLM
OT  - Aging
OT  - Autophagy
OT  - Caloric restriction mimetics (CRMs)
OT  - Neurodegenerative disorders
OT  - Neuroprotection
OT  - Redox signaling
EDAT- 2023/07/10 13:06
MHDA- 2023/09/05 06:42
CRDT- 2023/07/10 11:11
PHST- 2023/05/18 00:00 [received]
PHST- 2023/06/10 00:00 [accepted]
PHST- 2023/09/05 06:42 [medline]
PHST- 2023/07/10 13:06 [pubmed]
PHST- 2023/07/10 11:11 [entrez]
AID - 10.1007/s10522-023-10045-y [pii]
AID - 10.1007/s10522-023-10045-y [doi]
PST - ppublish
SO  - Biogerontology. 2023 Oct;24(5):679-708. doi: 10.1007/s10522-023-10045-y. Epub 
      2023 Jul 10.