PMID- 37431463
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231101
IS  - 2692-9384 (Electronic)
IS  - 2692-9384 (Linking)
VI  - 2
IP  - 2
DP  - 2022 Jun
TI  - The association between peer-victimisation and structural and functional brain 
      outcomes: A systematic review.
PG  - e12081
LID - 10.1002/jcv2.12081 [doi]
LID - e12081
AB  - BACKGROUND: Peer adversity and aggression are common experiences in childhood and 
      adolescence which lead to poor mental health outcomes. To date, there has been no 
      review conducted on the neurobiological changes associated with relational 
      peer-victimisation, bullying and cyberbullying. METHODS: This systematic review 
      assessed structural and functional brain changes associated with 
      peer-victimisation, bullying, and cyberbullying from 1 January 2000 to April 
      2021. A systematic search of Psychoinfo, Pubmed, and Scopus was performed 
      independently by two reviewers using predefined criteria. Twenty-six studies met 
      the selection criteria and were considered for review. RESULTS: The data 
      collected shows altered brain activation of regions implicated in processing 
      reward, social pain, and affect; and heightened sensitivity and more widespread 
      activation of brain regions during acute social exclusion, most notably in the 
      amygdala, left parahippocampal gyrus, and fusiform gyrus, associated with 
      victimisation exposure. In addition, victimised youths also demonstrated greater 
      risk-taking behaviours following acute social exclusion showing greater ventral 
      striatum-inferior frontal gyrus coupling, activation in the bilateral amygdala, 
      orbital frontal cortex (OFC), medial prefrontal cortex (MPFC), temporoparietal 
      junction (TPJ), medial posterior parietal cortex (MPPC) and dorsomedial 
      prefrontal cortex (dmPFC), suggesting greater social monitoring, seeking of 
      inclusion, and more effortful cognitive control. The studies included 
      participants from a very broad developmental age range, mostly using 
      cross-sectional measure of peer-victimisation exposure, at varying developmental 
      stages. CONCLUSIONS: This review highlights the need for more neuroimaging 
      studies in cyberbullying, as well as longitudinal studies across more diverse 
      samples for investigating gender, age, and developmental interactions with 
      peer-victimising. This also brings to attention the importance of addressing 
      bullying victimisation particularly in adolescence, given the evidence for social 
      stress in heightening developmentally sensitive processes which are associated 
      with depression, anxiety, and externalising symptoms.
CI  - (c) 2022 The Authors. JCPP Advances published by John Wiley & Sons Ltd on behalf of 
      Association for Child and Adolescent Mental Health.
FAU - Ke, Tianyuan
AU  - Ke T
AUID- ORCID: 0000-0001-9375-4028
AD  - Developmental Psychopathology Lab King's College London Institute of Psychiatry, 
      Psychology & Neuroscience London UK.
AD  - Department of Psychology Institute of Psychiatry, Psychology and Neuroscience 
      King's College London London UK.
FAU - De Simoni, Sara
AU  - De Simoni S
AD  - Department of Psychology Institute of Psychiatry, Psychology and Neuroscience 
      King's College London London UK.
FAU - Barker, Edward
AU  - Barker E
AUID- ORCID: 0000-0002-9914-8958
AD  - Developmental Psychopathology Lab King's College London Institute of Psychiatry, 
      Psychology & Neuroscience London UK.
AD  - Department of Psychology Institute of Psychiatry, Psychology and Neuroscience 
      King's College London London UK.
FAU - Smith, Patrick
AU  - Smith P
AUID- ORCID: 0000-0002-0743-7972
AD  - Department of Psychology Institute of Psychiatry, Psychology and Neuroscience 
      King's College London London UK.
LA  - eng
PT  - Journal Article
DEP - 20220512
PL  - United States
TA  - JCPP Adv
JT  - JCPP advances
JID - 9918250414706676
PMC - PMC10242938
OTO - NOTNLM
OT  - adolescents
OT  - bullying
OT  - children
OT  - cyberbullying
OT  - emerging adults
OT  - neuroimaging
OT  - peer-victimization
OT  - psychopathology
COIS- Edward Barker is a member of the editorial advisory board for JCPP Advances. The 
      remaining authors have declared that they have no competing or potential 
      conflicts of interest.
EDAT- 2022/05/12 00:00
MHDA- 2022/05/12 00:01
PMCR- 2022/05/12
CRDT- 2023/07/11 03:37
PHST- 2021/10/08 00:00 [received]
PHST- 2022/03/31 00:00 [accepted]
PHST- 2022/05/12 00:01 [medline]
PHST- 2022/05/12 00:00 [pubmed]
PHST- 2023/07/11 03:37 [entrez]
PHST- 2022/05/12 00:00 [pmc-release]
AID - JCV212081 [pii]
AID - 10.1002/jcv2.12081 [doi]
PST - epublish
SO  - JCPP Adv. 2022 May 12;2(2):e12081. doi: 10.1002/jcv2.12081. eCollection 2022 Jun.