PMID- 37433989
OWN - NLM
STAT- MEDLINE
DCOM- 20230831
LR  - 20240402
IS  - 1861-0293 (Electronic)
IS  - 1340-3443 (Linking)
VI  - 77
IP  - 4
DP  - 2023 Sep
TI  - Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via 
      regulating serum uric acid level and relieving inflammatory reaction.
PG  - 867-879
LID - 10.1007/s11418-023-01729-3 [doi]
AB  - Hyperuricemia is an independent risk factor for chronic kidney disease. We have 
      previously showed the uric-acid-lowering effect of Eurycoma longifolia Jack, yet 
      the renal protective effect and mechanism of E. longifolia remain obscure. The 
      mouse model of hyperuricemic nephropathy was induced by adenine combined with 
      potassium oxonate in male C57BL/6 J mice. E. Longifolia alkaloid components could 
      reduce the level of serum uric acid by regulating the expression of hepatic 
      phosphoribosyl pyrophosphate synthase (PRPS), hypoxanthine-guanine phosphoribosyl 
      transferase (HPRT), and renal urate transporter organic anion transporter 1 
      (OAT1) and ATP-binding box subfamily G member 2 (ABCG2) in HN mice. Additionally, 
      E. Longifolia alkaloid components alleviated renal injury and function caused by 
      hyperuricemia, which was characterized by improving renal histopathology, 
      reducing urea nitrogen and creatinine levels. E. Longifolia alkaloid components 
      treatment could reduce the secretion of pro-inflammatory factors by inhibiting 
      the activation of NF-kappaB and NLRP3 inflammatory signaling pathways, including 
      tumor necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), 
      interleukin-1 beta (IL-1beta), and regulated activated normal T cell expression and 
      secretion proteins (RANTES). Meanwhile, E. longifolia alkaloid components 
      improved renal fibrosis, inhibited the transformation of calcium-dependent cell 
      adhesion molecule E (E-cadherin) to alpha-smooth muscle actin (alpha-SMA) transformation, 
      and decreased collagen 1 expression in HN mice.
CI  - (c) 2023. The Author(s) under exclusive licence to The Japanese Society of 
      Pharmacognosy.
FAU - Wang, Dan
AU  - Wang D
AD  - Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, Jinghai 
      District, Tianjin, 301617, China.
FAU - Liu, Lin
AU  - Liu L
AD  - State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of 
      Traditional Chinese Medicine, 10 Poyang Lake Road, Jinghai District, Tianjin, 
      301617, China.
FAU - Li, Kaiwen
AU  - Li K
AD  - Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, Jinghai 
      District, Tianjin, 301617, China.
FAU - Cao, Huiya
AU  - Cao H
AD  - Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, Jinghai 
      District, Tianjin, 301617, China.
FAU - Liu, Mengyang
AU  - Liu M
AD  - State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of 
      Traditional Chinese Medicine, 10 Poyang Lake Road, Jinghai District, Tianjin, 
      301617, China.
FAU - Chen, Qian
AU  - Chen Q
AD  - Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, Jinghai 
      District, Tianjin, 301617, China.
FAU - Wu, Yuzheng
AU  - Wu Y
AD  - Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, Jinghai 
      District, Tianjin, 301617, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of 
      Traditional Chinese Medicine, 10 Poyang Lake Road, Jinghai District, Tianjin, 
      301617, China. zhwwxzh@tjutcm.edu.cn.
FAU - Wang, Tao
AU  - Wang T
AD  - Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, Jinghai 
      District, Tianjin, 301617, China. wangtao@tjutcm.edu.cn.
AD  - State Key Laboratory of Bioactive Substance and Function of Natural Medicines, 
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 
      100050, China. wangtao@tjutcm.edu.cn.
LA  - eng
GR  - 81173524/National Natural Science Foundation of China/
GR  - 81673688/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20230712
PL  - Japan
TA  - J Nat Med
JT  - Journal of natural medicines
JID - 101518405
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Male
MH  - Mice
MH  - Animals
MH  - *Hyperuricemia/chemically induced/drug therapy
MH  - Uric Acid
MH  - *Eurycoma
MH  - Mice, Inbred C57BL
MH  - Kidney/metabolism/pathology
MH  - Inflammation/metabolism
OTO - NOTNLM
OT  - Eurycoma longifolia alkaloid components
OT  - Hyperuricemic nephropathy
OT  - Inflammation response
OT  - Renal fibrosis
OT  - Uric acid
EDAT- 2023/07/12 01:07
MHDA- 2023/08/31 06:41
CRDT- 2023/07/11 23:31
PHST- 2023/05/03 00:00 [received]
PHST- 2023/06/23 00:00 [accepted]
PHST- 2023/08/31 06:41 [medline]
PHST- 2023/07/12 01:07 [pubmed]
PHST- 2023/07/11 23:31 [entrez]
AID - 10.1007/s11418-023-01729-3 [pii]
AID - 10.1007/s11418-023-01729-3 [doi]
PST - ppublish
SO  - J Nat Med. 2023 Sep;77(4):867-879. doi: 10.1007/s11418-023-01729-3. Epub 2023 Jul 
      12.