PMID- 37434331
OWN - NLM
STAT- MEDLINE
DCOM- 20231109
LR  - 20231129
IS  - 1613-6829 (Electronic)
IS  - 1613-6810 (Linking)
VI  - 19
IP  - 45
DP  - 2023 Nov
TI  - Engineered Bio-Heterojunction with Infection-Primed H(2) S Liberation for Boosted 
      Angiogenesis and Infectious Cutaneous Regeneration.
PG  - e2304324
LID - 10.1002/smll.202304324 [doi]
AB  - Photodynamic therapy (PDT) acts as a powerful weapon against infectious diseases 
      for its enormous antimicrobial activity that quickly elicits storms of reactive 
      oxygen species (ROS). Nevertheless, redundant ROS during treatment inevitably 
      bring detriments in revascularization. To address this dilemma, an innovative P-N 
      bio-heterojunction (bio-HJ) material consisting of p-type copper sulfide (p-CuS), 
      n-type bismuth sulfide (n-Bi(2) S(3) ), and lactate oxidase (LOx) for effective 
      treatment of recalcitrant infectious wounds by promoting angiogenesis is devised. 
      LOx exhausts lactic acid accumulated in infection environment and converts it to 
      hydrogen peroxide (H(2) O(2) ), which subsequently yields bactericidal hydroxyl 
      radicals (.OH) via Fenton-like reactions. Ultimately, the P-N bio-HJs exert 
      synergistic photothermal, photodynamic, and chemodynamic effects for rapid 
      bacterial annihilation. Moreover, in vitro and RNA-seq analyses reveal that the 
      crafted bio-HJs dramatically expedite the proliferation of L929 cells and promote 
      angiogenesis by up-regulating angiogenic gene expression in hypoxia-inducible 
      factor-1 (HIF-1) signaling pathway, which may ascribe to the evolution of H(2) S 
      in response to the infection microenvironment. Critically, results of in vivo 
      experiments have authenticated that the bio-HJs significantly boost healing rates 
      of full-thickness wounds by slaughtering bacteria, elevating angiogenesis, and 
      promoting cytothesis. As envisioned, this work furnishes a novel tactic for the 
      effective treatment of bacteria-invaded wound using H(2) S-liberating P-N 
      bio-HJs.
CI  - (c) 2023 Wiley-VCH GmbH.
FAU - Huang, Yiling
AU  - Huang Y
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, School of Chemical Engineering, Sichuan University, Chengdu, 610065, 
      China.
AD  - Department of Cariology and Endodontics, West China Hospital of Stomatology, 
      Sichuan University, Chengdu, 610041, China.
FAU - Huang, Yixuan
AU  - Huang Y
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, School of Chemical Engineering, Sichuan University, Chengdu, 610065, 
      China.
AD  - State Key Laboratory of Polymer Materials Engineering, Sichuan University, 
      Chengdu, 610065, China.
FAU - Wang, Ziyou
AU  - Wang Z
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, School of Chemical Engineering, Sichuan University, Chengdu, 610065, 
      China.
AD  - Department of Cariology and Endodontics, West China Hospital of Stomatology, 
      Sichuan University, Chengdu, 610041, China.
FAU - Yu, Sheng
AU  - Yu S
AD  - Department of Chemistry, Washington State University, Pullman, WA, 99164, USA.
FAU - Johnson, Hannah M
AU  - Johnson HM
AD  - Department of Chemistry, Washington State University, Pullman, WA, 99164, USA.
FAU - Yang, Yingming
AU  - Yang Y
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, School of Chemical Engineering, Sichuan University, Chengdu, 610065, 
      China.
AD  - Department of Cariology and Endodontics, West China Hospital of Stomatology, 
      Sichuan University, Chengdu, 610041, China.
FAU - Li, Meng
AU  - Li M
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, School of Chemical Engineering, Sichuan University, Chengdu, 610065, 
      China.
AD  - Department of Cariology and Endodontics, West China Hospital of Stomatology, 
      Sichuan University, Chengdu, 610041, China.
FAU - Li, Jiyao
AU  - Li J
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, School of Chemical Engineering, Sichuan University, Chengdu, 610065, 
      China.
AD  - Department of Cariology and Endodontics, West China Hospital of Stomatology, 
      Sichuan University, Chengdu, 610041, China.
FAU - Deng, Yi
AU  - Deng Y
AUID- ORCID: 0000-0002-1765-5244
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, School of Chemical Engineering, Sichuan University, Chengdu, 610065, 
      China.
AD  - State Key Laboratory of Polymer Materials Engineering, Sichuan University, 
      Chengdu, 610065, China.
AD  - Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, 
      999077, China.
FAU - Liang, Kunneng
AU  - Liang K
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, School of Chemical Engineering, Sichuan University, Chengdu, 610065, 
      China.
AD  - Department of Cariology and Endodontics, West China Hospital of Stomatology, 
      Sichuan University, Chengdu, 610041, China.
LA  - eng
GR  - 82270970/National Natural Science Foundation of China/
GR  - 32271392/National Natural Science Foundation of China/
GR  - 82170949/National Natural Science Foundation of China/
GR  - 81991500/National Natural Science Foundation of China/
GR  - 81961160736/National Natural Science Foundation of China/
GR  - 81991501/National Natural Science Foundation of China/
GR  - 2022YFS0288/Key Research and Development Program of Sichuan Province/
GR  - 2021YJ0049/Sichuan Science and Technology Program/
GR  - 2021-YF05-02061-SN/Chengdu Science and Technology Support Program/
GR  - 2020-GH03-00005-HZ/Chengdu International Science and Technology Cooperation 
      Foundation/
GR  - 2017-GH02-00025-HZ/Chengdu International Science and Technology Cooperation 
      Foundation/
GR  - 0040304153013/Postdoctoral Cross Funding of Sichuan University/
GR  - sklpme2019-2-05/State Key Laboratory of Polymer Materials Engineering/
GR  - 2020CDLZ-5/Sichuan University-Luzhou City Special Funding for Strategic 
      Cooperation/
GR  - 2018M643507(L.K.N)/China Postdoctoral Foundation/
GR  - 2022NSFSC0361/Natural Science Foundation of Sichuan/
GR  - Fundamental Research Funds for the Central Universities (SCU)/
GR  - Hong Kong Scholar/
PT  - Journal Article
DEP - 20230711
PL  - Germany
TA  - Small
JT  - Small (Weinheim an der Bergstrasse, Germany)
JID - 101235338
RN  - 0 (Reactive Oxygen Species)
RN  - 3352-57-6 (Hydroxyl Radical)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Reactive Oxygen Species/metabolism
MH  - *Skin/metabolism
MH  - *Photochemotherapy
MH  - Hydroxyl Radical
MH  - Regeneration
MH  - Hydrogen Peroxide
OTO - NOTNLM
OT  - antibacterial
OT  - bio-heterojunction
OT  - phototherapy
OT  - tissue regeneration
EDAT- 2023/07/12 06:42
MHDA- 2023/11/09 06:41
CRDT- 2023/07/12 01:23
PHST- 2023/06/29 00:00 [revised]
PHST- 2023/05/23 00:00 [received]
PHST- 2023/11/09 06:41 [medline]
PHST- 2023/07/12 06:42 [pubmed]
PHST- 2023/07/12 01:23 [entrez]
AID - 10.1002/smll.202304324 [doi]
PST - ppublish
SO  - Small. 2023 Nov;19(45):e2304324. doi: 10.1002/smll.202304324. Epub 2023 Jul 11.