PMID- 37434422
OWN - NLM
STAT- Publisher
LR  - 20231015
IS  - 2190-6009 (Electronic)
IS  - 2190-5991 (Print)
IS  - 2190-5991 (Linking)
VI  - 14
IP  - 5
DP  - 2023 Oct
TI  - Association of intrinsic capacity with incidence and mortality of cardiovascular 
      disease: Prospective study in UK Biobank.
PG  - 2054-2063
LID - 10.1002/jcsm.13283 [doi]
AB  - BACKGROUND: The World Health Organization proposed the concept of intrinsic 
      capacity (IC; the composite of all the physical and mental capacities of the 
      individual) as central for healthy ageing. However, little research has 
      investigated the interaction and joint associations of IC with cardiovascular 
      disease (CVD) incidence and CVD mortality in middle- and older-aged adults. 
      METHODS: Using data from 443 130 UK Biobank participants, we analysed seven 
      biomarkers capturing the level of functioning of five domains of IC to calculate 
      a total IC score (ranging from 0 [better IC] to +4 points [poor IC]). 
      Associations between IC score and incidence of six long-term CVD conditions 
      (hypertension, stroke/transient ischaemic attack stroke, peripheral vascular 
      disease, atrial fibrillation/flutter, coronary artery disease and heart failure), 
      and grouped mortality from these conditions were estimated using Cox proportional 
      models, with a 1-year landmark analysis to triangulate the findings. RESULTS: 
      Over 10.6 years of follow-up, CVD morbidity grouped (n = 384 380 participants for 
      the final analytic sample) was associated with IC scores (0 to +4): mean hazard 
      ratio (HR) [95% confidence interval, CI] 1.11 [1.08-1.14], 1.20 [1.16-1.24], 1.29 
      [1.23-1.36] and 1.56 [1.45-1.59] in men (C-index = 0.68), and 1.17 [1.13-1.20], 
      1.30 [1.26-1.36], 1.52 [1.45-1.59] and 1.78 [1.67-1.89] in women 
      (C-index = 0.70). In regard to mortality, our results indicated that the higher 
      IC score (+4 points) was associated with a significant increase in subsequent CVD 
      mortality (mean HR [95% CI]: 2.10 [1.81-2.43] in men [C-index = 0.75] and 2.29 
      [1.85-2.84] in women [C-index = 0.78]). Results of all sensitivity analyses by 
      full sample, sex and age categories were largely consistent independent of major 
      confounding factors (P < 0.001). CONCLUSIONS: IC deficit score is a powerful 
      predictor of functional trajectories and vulnerabilities of the individual in 
      relation to CVD incidence and premature death. Monitoring an individual's IC 
      score may provide an early-warning system to initiate preventive efforts.
CI  - (c) 2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John 
      Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting 
      Disorders.
FAU - Ramirez-Velez, Robinson
AU  - Ramirez-Velez R
AUID- ORCID: 0000-0003-3075-6960
AD  - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de 
      Navarra (UPNA), IdiSNA, Pamplona, Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 
      Madrid, Spain.
FAU - Iriarte-Fernandez, Maria
AU  - Iriarte-Fernandez M
AD  - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de 
      Navarra (UPNA), IdiSNA, Pamplona, Spain.
FAU - Santafe, Guzman
AU  - Santafe G
AUID- ORCID: 0000-0003-3951-6250
AD  - Department of Statistics, Computer Science, and Mathematics, Universidad Publica 
      de Navarra (UPNA), Pamplona, Spain.
AD  - InaMat, Universidad Publica de Navarra (UPNA), Pamplona, Spain.
FAU - Malanda, Armando
AU  - Malanda A
AUID- ORCID: 0000-0002-3122-9049
AD  - Department of Electrical and Electronic Engineering, Universidad Publica de 
      Navarra (UPNA), Pamplona, Spain.
FAU - Beard, John R
AU  - Beard JR
AUID- ORCID: 0000-0002-8557-0242
AD  - Columbia Aging Center, Columbia University, New York, NY, USA.
FAU - Garcia-Hermoso, Antonio
AU  - Garcia-Hermoso A
AUID- ORCID: 0000-0002-1397-7182
AD  - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de 
      Navarra (UPNA), IdiSNA, Pamplona, Spain.
FAU - Izquierdo, Mikel
AU  - Izquierdo M
AUID- ORCID: 0000-0002-1506-4272
AD  - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de 
      Navarra (UPNA), IdiSNA, Pamplona, Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 
      Madrid, Spain.
LA  - eng
GR  - Universidad Publica de Navarra/
PT  - Journal Article
DEP - 20230711
PL  - Germany
TA  - J Cachexia Sarcopenia Muscle
JT  - Journal of cachexia, sarcopenia and muscle
JID - 101552883
SB  - IM
PMC - PMC10570093
OTO - NOTNLM
OT  - biological ageing
OT  - biomarkers
OT  - incident pathologies
OT  - intrinsic capacity
OT  - mortality
COIS- We declare no competing interests.
EDAT- 2023/07/12 06:42
MHDA- 2023/07/12 06:42
PMCR- 2023/07/11
CRDT- 2023/07/12 02:23
PHST- 2023/05/28 00:00 [revised]
PHST- 2023/02/26 00:00 [received]
PHST- 2023/06/11 00:00 [accepted]
PHST- 2023/07/12 06:42 [pubmed]
PHST- 2023/07/12 06:42 [medline]
PHST- 2023/07/12 02:23 [entrez]
PHST- 2023/07/11 00:00 [pmc-release]
AID - JCSM13283 [pii]
AID - 10.1002/jcsm.13283 [doi]
PST - ppublish
SO  - J Cachexia Sarcopenia Muscle. 2023 Oct;14(5):2054-2063. doi: 10.1002/jcsm.13283. 
      Epub 2023 Jul 11.