PMID- 37435782
OWN - NLM
STAT- MEDLINE
DCOM- 20231004
LR  - 20231004
IS  - 1463-1326 (Electronic)
IS  - 1462-8902 (Linking)
VI  - 25
IP  - 11
DP  - 2023 Nov
TI  - Healthy lifestyle and all-cause and cause-specific dementia in individuals with 
      type 2 diabetes and the roles of diabetes duration and insulin use in UK Biobank 
      cohort.
PG  - 3202-3211
LID - 10.1111/dom.15215 [doi]
AB  - AIMS: To examine the effect of a healthy lifestyle score derived from seven 
      lifestyle factors recommended by the diabetes management guidelines on all-cause 
      and cause-specific dementia in individuals with type 2 diabetes mellitus (T2DM), 
      and how diabetes duration and insulin use status modify their association. 
      MATERIALS AND METHODS: This study analysed data of 459 840 participants from the 
      UK Biobank. We used Cox proportional hazards models to estimate hazard ratios 
      (HRs) and 95% confidence intervals for the association of an overall healthy 
      lifestyle score with all-cause and cause-specific dementia of Alzheimer's 
      disease, vascular dementia and non-Alzheimer non-vascular dementia. RESULTS: 
      Using diabetes-free participants who scored 5-7 as the reference group, in 
      diabetes-free participants, we observed higher healthy lifestyle score was 
      related to lower risk of all-cause and cause-specific dementia. However, in 
      people with T2DM, those scored 2-3, 4 and 5-7 all had around the two-time risk of 
      all-cause dementia (HR: 2.20-2.36), while those scored 0-1 had over a three-time 
      risk (HR: 3.14, 95% confidence interval 2.34-4.21). A dose-response trend was 
      observed with vascular dementia (each 2-point increase: 0.75, 0.61-0.93) and no 
      significant association with Alzheimer's disease (0.95, 0.77-1.16). The reduced 
      risk of all-cause and cause-specific dementia with higher lifestyle score was 
      observed in patients with a diabetes duration less than 10 years, or in patients 
      with no insulin use. CONCLUSION: In people with T2DM, higher healthy lifestyle 
      score was associated with lower risk of all-cause dementia. Diabetes duration and 
      insulin use moderated the association between healthy lifestyle score and risk of 
      dementia.
CI  - (c) 2023 John Wiley & Sons Ltd.
FAU - Zhou, Chunmiao
AU  - Zhou C
AD  - Department of Epidemiology, School of Public Halth, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
FAU - Dong, Caiyun
AU  - Dong C
AD  - Department of Epidemiology, School of Public Halth, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
FAU - Wang, Qi
AU  - Wang Q
AD  - Centre for Health Management and Policy Research, School of Public Health, 
      Cheeloo College of Medicine, Shandong University, Jinan, China.
AD  - NHC Key Lab of Health Economics and Policy Research (Shandong University), Jinan, 
      China.
FAU - Fu, Chunying
AU  - Fu C
AD  - Department of Epidemiology, School of Public Halth, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
FAU - Xie, Ziwei
AU  - Xie Z
AD  - Department of Epidemiology, School of Public Halth, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
FAU - Hao, Wenting
AU  - Hao W
AD  - Centre for Health Management and Policy Research, School of Public Health, 
      Cheeloo College of Medicine, Shandong University, Jinan, China.
AD  - NHC Key Lab of Health Economics and Policy Research (Shandong University), Jinan, 
      China.
FAU - Sun, Huizi
AU  - Sun H
AD  - Department of Epidemiology, School of Public Halth, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
FAU - Zhu, Dongshan
AU  - Zhu D
AUID- ORCID: 0000-0002-0697-7432
AD  - Department of Epidemiology, School of Public Halth, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230712
PL  - England
TA  - Diabetes Obes Metab
JT  - Diabetes, obesity & metabolism
JID - 100883645
RN  - 0 (Insulins)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy/epidemiology
MH  - *Alzheimer Disease
MH  - *Dementia, Vascular
MH  - Biological Specimen Banks
MH  - Risk Factors
MH  - Healthy Lifestyle
MH  - United Kingdom/epidemiology
MH  - *Insulins
OTO - NOTNLM
OT  - dementia
OT  - diabetes duration
OT  - healthy lifestyle
OT  - insulin use
OT  - type 2 diabetes
EDAT- 2023/07/12 06:42
MHDA- 2023/10/04 06:43
CRDT- 2023/07/12 05:29
PHST- 2023/06/26 00:00 [revised]
PHST- 2023/04/18 00:00 [received]
PHST- 2023/06/27 00:00 [accepted]
PHST- 2023/10/04 06:43 [medline]
PHST- 2023/07/12 06:42 [pubmed]
PHST- 2023/07/12 05:29 [entrez]
AID - 10.1111/dom.15215 [doi]
PST - ppublish
SO  - Diabetes Obes Metab. 2023 Nov;25(11):3202-3211. doi: 10.1111/dom.15215. Epub 2023 
      Jul 12.