PMID- 37436532
OWN - NLM
STAT- MEDLINE
DCOM- 20230714
LR  - 20230816
IS  - 1432-8798 (Electronic)
IS  - 0304-8608 (Linking)
VI  - 168
IP  - 8
DP  - 2023 Jul 12
TI  - Genetic and pathogenic characterization of an NADC-34-like isolate of porcine 
      reproductive and respiratory syndrome virus.
PG  - 205
LID - 10.1007/s00705-023-05822-6 [doi]
AB  - In this study, an NADC34-like strain of porcine reproductive and respiratory 
      syndrome virus (PRRSV), YC-2020, was isolated from a pig farm in Yuncheng, Shanxi 
      Province, China. Phylogenetic and molecular evolutionary analysis showed that the 
      genome sequence of YC-2020 was very similar to those of NADC34-like PRRSV strains 
      in the ORF2-7 region. However, it was more closely related to NADC30-like PRRSV 
      and highly pathogenic (HP) PRRSV in the NSP2 and NSP3-9 coding regions, 
      respectively, suggesting that recombination had occurred between viruses 
      belonging to lineages 1 and 8. Piglets infected with YC-2020 exhibited mild 
      clinical signs, but they had severe histopathological lesions in their lungs. 
      These findings reveal novel genetic and pathogenic features of this isolate.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, 
      part of Springer Nature.
FAU - Zhao, Yongxin
AU  - Zhao Y
AD  - College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, 
      Shaanxi, China.
FAU - Wang, Ruiqing
AU  - Wang R
AD  - College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, 
      Shaanxi, China.
FAU - Li, Wei
AU  - Li W
AD  - College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, 
      Shaanxi, China.
FAU - Yu, Chenfei
AU  - Yu C
AD  - College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, 
      Shaanxi, China.
FAU - Zhang, Riteng
AU  - Zhang R
AD  - College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, 
      Shaanxi, China.
FAU - Hu, Ruochen
AU  - Hu R
AD  - College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, 
      Shaanxi, China.
FAU - Guo, Ruhai
AU  - Guo R
AD  - College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, 
      Shaanxi, China.
FAU - Yang, Zengqi
AU  - Yang Z
AD  - College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, 
      Shaanxi, China.
FAU - Zhou, Yefei
AU  - Zhou Y
AD  - Department of Life Science, Nanjing Xiaozhuang University, 211171, Jiangsu, 
      Nanjing, China. yfzhou@njxzc.edu.cn.
FAU - Wang, Xinglong
AU  - Wang X
AUID- ORCID: 0000-0002-5764-8209
AD  - College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, 
      Shaanxi, China. wxlong@nwsuaf.edu.cn.
LA  - eng
GR  - No. 31672581/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20230712
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
RN  - 88437-23-4 (N-acetoacetyl-N-deacetylcolchicine)
SB  - IM
MH  - Animals
MH  - Swine
MH  - *Porcine respiratory and reproductive syndrome virus/genetics
MH  - *Porcine Reproductive and Respiratory Syndrome/genetics
MH  - Phylogeny
MH  - Genome, Viral
MH  - China
MH  - Genetic Variation
EDAT- 2023/07/12 13:07
MHDA- 2023/07/14 13:07
CRDT- 2023/07/12 11:08
PHST- 2023/05/03 00:00 [received]
PHST- 2023/05/25 00:00 [accepted]
PHST- 2023/07/14 13:07 [medline]
PHST- 2023/07/12 13:07 [pubmed]
PHST- 2023/07/12 11:08 [entrez]
AID - 10.1007/s00705-023-05822-6 [pii]
AID - 10.1007/s00705-023-05822-6 [doi]
PST - epublish
SO  - Arch Virol. 2023 Jul 12;168(8):205. doi: 10.1007/s00705-023-05822-6.