PMID- 37438984
OWN - NLM
STAT- MEDLINE
DCOM- 20230814
LR  - 20230814
IS  - 1753-0407 (Electronic)
IS  - 1753-0393 (Print)
IS  - 1753-0407 (Linking)
VI  - 15
IP  - 8
DP  - 2023 Aug
TI  - Interventional metabology: A review of bariatric arterial embolization and 
      endovascular denervation for treating metabolic disorders.
PG  - 665-673
LID - 10.1111/1753-0407.13437 [doi]
AB  - The rising prevalence of metabolic disorders such as obesity and type 2 diabetes 
      mellitus (T2DM) poses a major challenge to global health. Existing therapeutic 
      approaches have limitations, and there is a need for new, safe, and less invasive 
      treatments. Interventional metabolic therapy is a new addition to the treatment 
      arsenal for metabolic disorders. This review focuses on two interventional 
      techniques: bariatric arterial embolization (BAE) and endovascular denervation 
      (EDN). BAE involves embolizing specific arteries feeding ghrelin-producing cells 
      to suppress appetite and promote weight loss. EDN targets nerves that regulate 
      metabolic organs to improve glycemic control in T2DM patients. We describe the 
      current state of these techniques, their mechanisms of action, and the available 
      safety and effectiveness data. We also propose a new territory called 
      "Interventional Metabology" to encompass these and other interventional 
      approaches to treating metabolic disorders.
CI  - (c) 2023 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai 
      Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
FAU - Wang, Zhi
AU  - Wang Z
AUID- ORCID: 0000-0002-5056-2242
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
FAU - Zhu, Dan-Qi
AU  - Zhu DQ
AUID- ORCID: 0000-0001-5811-1860
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
FAU - Zhu, Xiang-Yun
AU  - Zhu XY
AUID- ORCID: 0000-0002-7605-6700
AD  - Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China.
AD  - Institute of Pancreas, Southeast University, Nanjing, China.
FAU - Liu, De-Chen
AU  - Liu DC
AUID- ORCID: 0000-0002-2776-441X
AD  - Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China.
AD  - Institute of Pancreas, Southeast University, Nanjing, China.
FAU - Cao, Qing-Yue
AU  - Cao QY
AUID- ORCID: 0000-0002-9324-9379
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
FAU - Pan, Tao
AU  - Pan T
AUID- ORCID: 0000-0002-1835-8516
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
FAU - Gu, Xiao-Chun
AU  - Gu XC
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
FAU - Li, Ling
AU  - Li L
AUID- ORCID: 0000-0003-0083-6978
AD  - Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China.
AD  - Institute of Pancreas, Southeast University, Nanjing, China.
FAU - Teng, Gao-Jun
AU  - Teng GJ
AUID- ORCID: 0000-0001-5800-3640
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
LA  - eng
GR  - 61821002/National Natural Science Foundation of China/
GR  - 82000740/National Natural Science Foundation of China/
GR  - 82170845/National Natural Science Foundation of China/
GR  - 82200929/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
DEP - 20230712
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/therapy
MH  - Obesity/metabolism
MH  - *Bariatrics
MH  - Weight Loss
MH  - Denervation
MH  - *Bariatric Surgery
PMC - PMC10415876
OTO - NOTNLM
OT  - 2型糖尿病
OT  - T2DM
OT  - intervention metabology
OT  - metabolic disorders
OT  - obesity
OT  - 代谢干预
OT  - 代谢紊乱
OT  - 肥胖
COIS- The authors declare that they have no competing interest.
EDAT- 2023/07/13 06:42
MHDA- 2023/08/14 06:42
PMCR- 2023/07/12
CRDT- 2023/07/13 02:08
PHST- 2023/05/12 00:00 [revised]
PHST- 2022/09/21 00:00 [received]
PHST- 2023/06/06 00:00 [accepted]
PHST- 2023/08/14 06:42 [medline]
PHST- 2023/07/13 06:42 [pubmed]
PHST- 2023/07/13 02:08 [entrez]
PHST- 2023/07/12 00:00 [pmc-release]
AID - JDB13437 [pii]
AID - 10.1111/1753-0407.13437 [doi]
PST - ppublish
SO  - J Diabetes. 2023 Aug;15(8):665-673. doi: 10.1111/1753-0407.13437. Epub 2023 Jul 
      12.