PMID- 37439179
OWN - NLM
STAT- MEDLINE
DCOM- 20230717
LR  - 20230718
IS  - 1673-4254 (Print)
IS  - 2663-0842 (Electronic)
IS  - 1673-4254 (Linking)
VI  - 43
IP  - 6
DP  - 2023 Jun 20
TI  - [Structural changes of the frontal cortex in depressed mice are associated with 
      decreased expression of brain-derived neurotrophic factor].
PG  - 1041-1046
LID - 10.12122/j.issn.1673-4254.2023.06.22 [doi]
AB  - OBJECTIVE: To investigate the changes in gray matter volume in depressive-like 
      mice and explore the possible mechanism. METHODS: Twenty-four 6-week-old C57 mice 
      were randomized equally into control group and model group, and the mice in the 
      model group were subjected to chronic unpredictable mild stimulation (CUMS) for 
      35 days. Magnetic resonance imaging was performed to examine structural changes 
      of the grey matter volume in depressive-like mice. The expression of 
      brain-derived neurotrophic factor (BDNF) in the grey matter of the mice was 
      detected using Western blotting and immunofluorescence staining. RESULTS: 
      Compared with the control mice, the mice with CUMS showed significantly decreased 
      central walking distance in the open field test (P < 0.05) and increased immobile 
      time in forced swimming test (P < 0.05). Magnetic resonance imaging showed that 
      the volume of the frontal cortex was significantly decreased in CUMS mice (P < 
      0.001, when the mass level was greater than or equal to 10 756, the FDRc was 
      corrected with P=0.05). Western blotting showed that the expression of mature 
      BDNF in the frontal cortex was significantly decreased in CUMS mice (P < 0.05), 
      and its expression began to decrease after the exposure to CUMS as shown by 
      immunofluorescence staining. The volume of different clusters obtained by 
      voxel-based morphometry (VBM) analysis was correlated with the expression level 
      of mature BDNF detected by Western blotting (P < 0.05). CONCLUSION: The decrease 
      of frontal cortex volume after CUMS is related with the reduction of mature BDNF 
      expression in the frontal cortex.
FAU - Cui, W
AU  - Cui W
AD  - Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 
      510515, China.
FAU - Gong, L
AU  - Gong L
AD  - Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 
      510515, China.
FAU - Chen, C
AU  - Chen C
AD  - Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 
      510120, China.
FAU - Tang, J
AU  - Tang J
AD  - First Clinical Medical College, Southern Medical University, Guangzhou 510515, 
      China.
FAU - Jin, X
AU  - Jin X
AD  - First Clinical Medical College, Southern Medical University, Guangzhou 510515, 
      China.
FAU - Li, Z
AU  - Li Z
AD  - First Clinical Medical College, Southern Medical University, Guangzhou 510515, 
      China.
FAU - Jing, L
AU  - Jing L
AD  - Operating Theater, TCM Integrated Hospital of Southern Medical University, 
      Guangzhou 510315, China.
FAU - Wen, G
AU  - Wen G
AD  - Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 
      510515, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Bdnf protein, mouse)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Blotting, Western
MH  - *Brain-Derived Neurotrophic Factor
MH  - Cerebral Cortex
MH  - *Depression/physiopathology
MH  - *Frontal Lobe/pathology
PMC - PMC10339313
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - chronic unpredictable mild stimulation
OT  - voxel-based morphometry
EDAT- 2023/07/13 06:42
MHDA- 2023/07/14 13:08
PMCR- 2023/06/20
CRDT- 2023/07/13 04:33
PHST- 2023/07/14 13:08 [medline]
PHST- 2023/07/13 06:42 [pubmed]
PHST- 2023/07/13 04:33 [entrez]
PHST- 2023/06/20 00:00 [pmc-release]
AID - nfykdxxb-43-6-1041 [pii]
AID - 10.12122/j.issn.1673-4254.2023.06.22 [doi]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2023 Jun 20;43(6):1041-1046. doi: 
      10.12122/j.issn.1673-4254.2023.06.22.