PMID- 37439970
OWN - NLM
STAT- MEDLINE
DCOM- 20230907
LR  - 20240312
IS  - 2162-4968 (Electronic)
IS  - 2162-4968 (Linking)
VI  - 12
IP  - 3
DP  - 2023 Sep
TI  - Binge-Eating Disorder Interventions: Review, Current Status, and Implications.
PG  - 406-416
LID - 10.1007/s13679-023-00517-0 [doi]
AB  - PURPOSE OF REVIEW: Binge-eating disorder (BED) is a serious psychiatric problem 
      associated with substantial morbidity that, unfortunately, frequently goes 
      unrecognized and untreated. This review summarizes the current status of 
      behavioral, psychological, pharmacological, and combined treatments for BED in 
      adults with a particular focus on recent findings and advances. RECENT FINDINGS: 
      Certain specific psychological treatments, notably CBT and IPT, and to some 
      extent DBT, have demonstrated efficacy and are associated with durable benefits 
      after treatment. Certain specific lower-cost scalable interventions, notably 
      CBTgsh, have demonstrated efficacy and have potential for broader uptake. An 
      important advance is the emerging RCT data indicating that BWL, a generalist and 
      available behavioral lifestyle intervention, has effectiveness that approximates 
      that of CBT for reducing binge eating and eating-disorder psychopathology but 
      with the advantage of also producing modest weight loss. There exists only one 
      pharmacological agent (LDX) with approval by the FDA for "moderate-to-severe" 
      BED. Research with other "off label" medications has yielded modest and mixed 
      outcomes with a few medications statistically superior to placebo over the 
      short-term and almost no longer-term data. Nearly all research combining 
      medications and psychological treatments has failed to enhance outcomes (combined 
      appears superior to pharmacotherapy-only but not to psychotherapy-only). Many 
      people with BED suffer in silence and shame, go untreated, and rarely receive 
      evidence-based treatments. Patients and practitioners need to recognize that 
      research has identified several effective interventions for BED, and these can 
      work quickly for many patients. Future research should identify treatments for 
      those who do not derive benefit from initial interventions, identify additional 
      pharmacological options, test agents with relevant mechanisms of action, and 
      utilize innovative adaptative "SMART" designs to identify treatments to enhance 
      outcomes among initial responders and to test alternative treatments to assist 
      initial non-responders.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Grilo, Carlos M
AU  - Grilo CM
AUID- ORCID: 0000-0003-0245-3444
AD  - Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. 
      carlos.grilo@yale.edu.
AD  - Yale Program for Obesity Weight and Eating Research (POWER), New Haven, CT, USA. 
      carlos.grilo@yale.edu.
FAU - Juarascio, Adrienne
AU  - Juarascio A
AD  - Department of Psychological and Brain Sciences, Drexel University, Philadelphia, 
      PA, USA.
AD  - Drexel University Center for Weight, Eating and Lifestyle Science (WELL), 
      Philadelphia, PA, USA.
LA  - eng
GR  - R01 DK117072/DK/NIDDK NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - R01 DK112771/DK/NIDDK NIH HHS/United States
GR  - DK114075/DK/NIDDK NIH HHS/United States
GR  - R01 DK049587/DK/NIDDK NIH HHS/United States
GR  - R01 DK114075/DK/NIDDK NIH HHS/United States
GR  - 112771/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20230713
PL  - United States
TA  - Curr Obes Rep
JT  - Current obesity reports
JID - 101578283
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Binge-Eating Disorder/psychology
MH  - Psychotherapy
MH  - Behavior Therapy
MH  - Weight Loss
MH  - *Bulimia
MH  - Treatment Outcome
PMC - PMC10528223
MID - NIHMS1920357
OTO - NOTNLM
OT  - Behavior therapy
OT  - Binge eating
OT  - Cognitive-behavioral therapy
OT  - Eating disorders
OT  - Obesity
OT  - Pharmacotherapy
OT  - Treatment
OT  - Weight loss
COIS- Dr. Grilo declares no conflicts of interest. Dr. Grilo reports broader interests, 
      which did not influence this research, including Honoraria for lectures and CME 
      activities at universities and scientific conferences, and Royalties from 
      Guilford Press and Taylor & Francis Publishers for academic books.
EDAT- 2023/07/13 12:31
MHDA- 2023/09/07 06:42
PMCR- 2024/09/01
CRDT- 2023/07/13 11:13
PHST- 2023/06/09 00:00 [accepted]
PHST- 2024/09/01 00:00 [pmc-release]
PHST- 2023/09/07 06:42 [medline]
PHST- 2023/07/13 12:31 [pubmed]
PHST- 2023/07/13 11:13 [entrez]
AID - 10.1007/s13679-023-00517-0 [pii]
AID - 10.1007/s13679-023-00517-0 [doi]
PST - ppublish
SO  - Curr Obes Rep. 2023 Sep;12(3):406-416. doi: 10.1007/s13679-023-00517-0. Epub 2023 
      Jul 13.