PMID- 37440431
OWN - NLM
STAT- MEDLINE
DCOM- 20230726
LR  - 20230731
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 43
IP  - 7
DP  - 2023 Jul 26
TI  - Kaempferol improves acute kidney injury via inhibition of macrophage infiltration 
      in septic mice.
LID - 10.1042/BSR20230873 [doi]
LID - BSR20230873
AB  - Sepsis contributes to life-threatening circulatory and organ dysfunction by 
      dysregulating the host response to infection in critically ill patients. 
      Treatment in an Intensive Care Unit (ICU) can improve the survival of patients 
      who suffer from severe sepsis, but sepsis-associated acute kidney injury (SAKI) 
      is still one of the main causes of death. The existing treatment is mainly 
      focused on controlling microorganism induced infections by using drugs, such as 
      ulinastatin and glucocorticoid. Also, it is well documented that kaempferol, a 
      flavonoid derived from plant sources, improves septic mouse survival via 
      anti-inflammatory response. However, the mechanism of anti-inflammatory response 
      mediated by this flavonoid compound was little known. This study aims to 
      demonstrate the mechanisms of inflammatory response regulated by kaempferol 
      treatment during sepsis. We perform cecal ligation and puncture (CLP) injury as a 
      sepsis mouse model and evaluate organ injury in sepsis. The molecular (qRT-PCR 
      and Western Blot) and cellular profiling (IHC staining and Flow Cytometry) of the 
      immune responses illustrates that kaempferol decreases the expression of adhesion 
      molecular genes (ICAM-1 and VCAM-1) and monocyte chemoattractant protein-1 
      (MCP-1), thereby inhibiting F4/80+ macrophages infiltration in CLP-induced acute 
      kidney injury. Our data suggested that kaempferol alleviates acute kidney injury 
      via regulating F4/80+ macrophages infiltration in CLP-induced acute kidney 
      injury.
CI  - (c) 2023 The Author(s).
FAU - Xu, Zuqing
AU  - Xu Z
AD  - Department of Emergency Medicine Department, Shenzhen Longhua District Central 
      Hospital, Shenzhen 518110, China.
AD  - Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, 
      Shenzhen 518110, China.
FAU - Wang, Xiao
AU  - Wang X
AD  - Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, 
      Shenzhen 518110, China.
AD  - Department of Ultrasound, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, China.
FAU - Kuang, Wenbin
AU  - Kuang W
AD  - Department of Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, China.
FAU - Wang, Shiyang
AU  - Wang S
AD  - Department of Emergency Medicine Department, Shenzhen Longhua District Central 
      Hospital, Shenzhen 518110, China.
FAU - Zhao, Yanli
AU  - Zhao Y
AUID- ORCID: 0000-0001-9445-7666
AD  - Department of Emergency Medicine Department, Shenzhen Longhua District Central 
      Hospital, Shenzhen 518110, China.
AD  - Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, 
      Shenzhen 518110, China.
AD  - Department of Ultrasound, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, China.
AD  - Department of Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Kaempferols)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Kaempferols/therapeutic use
MH  - *Acute Kidney Injury/drug therapy
MH  - Macrophages/metabolism
MH  - Anti-Inflammatory Agents/pharmacology
MH  - *Sepsis/complications
PMC - PMC10372469
OTO - NOTNLM
OT  - Flavonoid
OT  - Immune cells
OT  - Inflammatory response
OT  - MCP-1
OT  - Macrophage recruitment
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2023/07/13 19:15
MHDA- 2023/07/26 06:42
PMCR- 2023/07/25
CRDT- 2023/07/13 12:53
PHST- 2023/05/10 00:00 [received]
PHST- 2023/07/10 00:00 [revised]
PHST- 2023/07/12 00:00 [accepted]
PHST- 2023/07/26 06:42 [medline]
PHST- 2023/07/13 19:15 [pubmed]
PHST- 2023/07/13 12:53 [entrez]
PHST- 2023/07/25 00:00 [pmc-release]
AID - 233284 [pii]
AID - BSR20230873 [pii]
AID - 10.1042/BSR20230873 [doi]
PST - ppublish
SO  - Biosci Rep. 2023 Jul 26;43(7):BSR20230873. doi: 10.1042/BSR20230873.