PMID- 3744133
OWN - NLM
STAT- MEDLINE
DCOM- 19861016
LR  - 20180216
IS  - 0301-0147 (Print)
IS  - 0301-0147 (Linking)
VI  - 16 Suppl 2
DP  - 1986
TI  - Intravenous and subcutaneous administration of Fragmin in deep venous thrombosis.
PG  - 25-9
AB  - 54 patients with venographically verified deep venous thrombosis (DVT) were 
      randomized to treatment with either intravenous infusions of 240 anti-Xa U/kg/12 
      h unfractionated heparin (UFH) or 240 or 120 anti-Xa U/kg/12 h of the low 
      molecular weight heparin Fragmin. Repeated venographies showed improvement in 48% 
      of the UFH-treated patients and 50 and 77%, respectively, in the Fragmin-treated 
      patients. Progression was seen only in the UFH-treated patients and was observed 
      in 11%. Two bleeding complications were seen in the Fragmin group in 2 patients 
      receiving the very high dose of 240 anti-Xa U/kg/12 h. Anti-Xa activity in plasma 
      and activated partial thromboplastin time (APTT) does not correlate in the 
      Fragmin-treated patients. Fragmin was as effective as UFH in preventing the 
      progress of thrombosis in DVT. In another study 120 anti-Xa U/kg Fragmin given 
      subcutaneously 2 times daily to 13 patients with DVT resulted in adequate anti-Xa 
      activity but with a tendency for accumulation of the Fragmin-induced activity. 
      Subcutaneous injections of Fragmin 2 times daily also appears to prevent the 
      progression of thrombosis effectively.
FAU - Lockner, D
AU  - Lockner D
FAU - Bratt, G
AU  - Bratt G
FAU - Tornebohm, E
AU  - Tornebohm E
FAU - Aberg, W
AU  - Aberg W
FAU - Granqvist, S
AU  - Granqvist S
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Switzerland
TA  - Haemostasis
JT  - Haemostasis
JID - 0371574
RN  - 9001-29-0 (Factor X)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.6 (Factor Xa)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Factor X/physiology
MH  - Factor Xa
MH  - Female
MH  - Heparin/*administration & dosage/pharmacology/therapeutic use
MH  - Humans
MH  - Injections, Intravenous
MH  - Injections, Subcutaneous
MH  - Male
MH  - Middle Aged
MH  - Partial Thromboplastin Time
MH  - Thrombophlebitis/*drug therapy
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1159/000215354 [doi]
PST - ppublish
SO  - Haemostasis. 1986;16 Suppl 2:25-9. doi: 10.1159/000215354.