PMID- 37441826
OWN - NLM
STAT- MEDLINE
DCOM- 20230915
LR  - 20231016
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 114
DP  - 2023 Oct
TI  - A very high-carbohydrate diet differentially affects whole-body glucose tolerance 
      and hepatic insulin resistance in rats.
PG  - 112113
LID - S0899-9007(23)00142-9 [pii]
LID - 10.1016/j.nut.2023.112113 [doi]
AB  - OBJECTIVES: This study was performed to assess the effects of long-term intake of 
      a very high carbohydrate (VHCHO) diet (76% of total energy from carbohydrate 
      [CHO]) on whole-body glucose tolerance and hepatic insulin resistance. METHODS 
      AND MATERIALS: Male Sprague Dawley rats were fed either a control high-CHO diet 
      (59% total energy from CHO; n = 8) or a VHCHO diet (76% total energy from CHO; 
      n = 8) for 17 wk. At 4, 8, 12, and 16 wk of the dietary intervention, oral 
      glucose tolerance test and homeostasis model assessment of insulin resistance 
      (HOMA-IR) measurements were taken to assess whole-body glucose tolerance and 
      hepatic insulin resistance, respectively. The triacylglycerol concentration in 
      the liver was measured at the end of the 17-wk intervention period. RESULTS: The 
      VHCHO diet group showed significantly higher muscle glucose transporter 4 content 
      and a smaller area under the curve for plasma glucose, but not insulin, in the 
      oral glucose tolerance test compared with the control group. On the other hand, 
      the VHCHO diet group had a significantly higher hepatic triacylglycerol 
      concentration and HOMA-IR measurement compared with the control group. The 
      hepatic triacylglycerol concentration was significantly and positively correlated 
      with HOMA-IR. CONCLUSIONS: The results of the present study suggest that 
      long-term intake of a VHCHO diet exerts differential effects on whole-body 
      glucose tolerance and hepatic insulin resistance.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Karasawa, Takuya
AU  - Karasawa T
AD  - Department of Life Sciences, Graduate School of Arts and Sciences, The University 
      of Tokyo, Tokyo, Japan; Research Fellow of Japan Society for the Promotion of 
      Science, Tokyo, Japan. Electronic address: karasawa-t@g.ecc.u-tokyo.ac.jp.
FAU - Koike, Atsuko
AU  - Koike A
AD  - Department of Life Sciences, Graduate School of Arts and Sciences, The University 
      of Tokyo, Tokyo, Japan.
FAU - Terada, Shin
AU  - Terada S
AD  - Department of Life Sciences, Graduate School of Arts and Sciences, The University 
      of Tokyo, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230602
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Triglycerides)
RN  - 0 (Dietary Carbohydrates)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - *Insulin Resistance
MH  - Rats, Sprague-Dawley
MH  - Liver
MH  - Triglycerides
MH  - Dietary Carbohydrates/pharmacology
MH  - Glucose/pharmacology
MH  - Blood Glucose
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Glucose tolerance test
OT  - Glucose transporter 4
OT  - Homeostatic model assessment for insulin resistance
OT  - Triacylglycerol
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/07/14 13:07
MHDA- 2023/09/15 06:43
CRDT- 2023/07/13 18:01
PHST- 2023/02/07 00:00 [received]
PHST- 2023/05/20 00:00 [revised]
PHST- 2023/05/30 00:00 [accepted]
PHST- 2023/09/15 06:43 [medline]
PHST- 2023/07/14 13:07 [pubmed]
PHST- 2023/07/13 18:01 [entrez]
AID - S0899-9007(23)00142-9 [pii]
AID - 10.1016/j.nut.2023.112113 [doi]
PST - ppublish
SO  - Nutrition. 2023 Oct;114:112113. doi: 10.1016/j.nut.2023.112113. Epub 2023 Jun 2.