PMID- 37442069 OWN - NLM STAT- MEDLINE DCOM- 20230809 LR - 20231119 IS - 1873-3778 (Electronic) IS - 0021-9673 (Print) IS - 0021-9673 (Linking) VI - 1705 DP - 2023 Aug 30 TI - Method development for thermal desorption-gas chromatography-tandem mass spectrometry (TD-GC-MS/MS) analysis of trace level fluorotelomer alcohols emitted from consumer products. PG - 464204 LID - S0021-9673(23)00425-9 [pii] LID - 10.1016/j.chroma.2023.464204 [doi] AB - The scientific foundation for per- and polyfluoroalkyl substances (PFAS) measurements in water, soils, sediments, biosolids, biota, and outdoor air has rapidly expanded; however, there are limited efforts devoted to developing analytical methods to measure vapor-phase PFAS in indoor air. A gas chromatography-tandem mass spectrometry (GC-MS/MS) method coupled with thermal desorption (TD) sorbent tube analysis was developed to quantify trace levels of fluorotelomer alcohols (FTOHs) emitted from consumer products in the indoor environment. Method evaluation included determination of instrument detection limits (IDLs), quality assurance checks of target standards purchased from different vendors, sample loss during storage, and TD sorbent breakthrough with tubes coupled in-series. The IDLs for TD-GC-MS/MS analyses ranged from 0.07 - 0.09 ng/tube. No significant loss of FTOHs was observed during stability tests over 28 days with relative standard deviations (RSDs) of spiked TD tubes ranging from 3.1 - 7.7% and the RSDs of polypropylene copolymer vial storage of standard solutions ranging from 4.3 - 8.4%. TD tube breakthrough was minimal with recovered FTOHs in the second tubes <1% of the spiked concentrations in the first tubes with carrier gas volume up to 20 L. The method has been applied to determine FTOH emissions from three consumer products in micro-scale chambers. A liquid stone cleaner/sealer product contained the highest levels of 6:2, 8:2, and 10:2 FTOHs, while the mattress pad products contained lower levels of 8:2 and 10:2 FTOHs. The emission parameters, including the initial emission factors and first order decay rate constants, were obtained based on the experimental data. The developed methods are sensitive and specific for analysis of all four target FTOHs (4:2, 6:2, 8:2, 10:2 FTOHs) with chamber testing. The methods can be extended to indoor air sampling and could be applicable to ambient air sampling. CI - Copyright (c) 2023. Published by Elsevier B.V. FAU - Robbins, Zachary G AU - Robbins ZG AD - Oak Ridge Institute for Science and Education Postdoctoral Fellow at U.S. Environmental Protection Agency, Office of Research and Development, Center for Environmental Measurement and Modeling, Research Triangle Park, NC 27711, United States. FAU - Liu, Xiaoyu AU - Liu X AD - U.S. Environmental Protection Agency, Office of Research and Development, Center for Environmental Measurement and Modeling, Research Triangle Park, NC 27711, United States. Electronic address: liu.xiaoyu@epa.gov. FAU - Schumacher, Brian A AU - Schumacher BA AD - U.S. Environmental Protection Agency, Office of Research and Development, Center for Environmental Measurement and Modeling, 960 College Station Road, Athens, GA 30605, United States. FAU - Smeltz, Marci G AU - Smeltz MG AD - U.S. Environmental Protection Agency, Office of Research and Development, Center for Environmental Measurement and Modeling, Research Triangle Park, NC 27711, United States. FAU - Liberatore, Hannah K AU - Liberatore HK AD - U.S. Environmental Protection Agency, Office of Research and Development, Center for Environmental Measurement and Modeling, Research Triangle Park, NC 27711, United States. LA - eng GR - EPA999999/ImEPA/Intramural EPA/United States PT - Journal Article DEP - 20230706 PL - Netherlands TA - J Chromatogr A JT - Journal of chromatography. A JID - 9318488 RN - 0 (fluorotelomer alcohols) RN - 0 (Fluorocarbons) SB - IM MH - *Tandem Mass Spectrometry/methods MH - Gas Chromatography-Mass Spectrometry/methods MH - *Fluorocarbons/analysis MH - Air/analysis PMC - PMC10563302 MID - NIHMS1927007 OTO - NOTNLM OT - Consumer products OT - Emissions OT - Gas chromatography- tandem mass spectrometry OT - PFAS OT - Thermal desorption COIS- Declaration of Competing Interest There is no competing interest for all authors. EDAT- 2023/07/14 13:06 MHDA- 2023/08/09 06:43 PMCR- 2024/08/30 CRDT- 2023/07/13 18:11 PHST- 2023/05/30 00:00 [received] PHST- 2023/07/04 00:00 [accepted] PHST- 2024/08/30 00:00 [pmc-release] PHST- 2023/08/09 06:43 [medline] PHST- 2023/07/14 13:06 [pubmed] PHST- 2023/07/13 18:11 [entrez] AID - S0021-9673(23)00425-9 [pii] AID - 10.1016/j.chroma.2023.464204 [doi] PST - ppublish SO - J Chromatogr A. 2023 Aug 30;1705:464204. doi: 10.1016/j.chroma.2023.464204. Epub 2023 Jul 6.