PMID- 37442536
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20230912
IS  - 1528-3933 (Electronic)
IS  - 1091-8531 (Linking)
VI  - 27
IP  - 4
DP  - 2023 Aug
TI  - Characterization of vision in pediatric retinoblastoma survivors beyond visual 
      acuity.
PG  - 188.e1-188.e6
LID - S1091-8531(23)00133-7 [pii]
LID - 10.1016/j.jaapos.2023.06.003 [doi]
AB  - BACKGROUND: Retinoblastoma (RB) and its associated treatments can significantly 
      impact visual acuity. However, little is known regarding other measures of 
      vision, such as contrast sensitivity or saccades. The aim of this study was to 
      describe contrast sensitivity and saccades in children treated for 
      retinoblastoma. METHODS: This cross-sectional study included children aged 5-17 
      years who had completed treatment for RB. Visual acuity, saccades via fixation 
      analysis, and contrast sensitivity by Cardiff contrast sensitivity were assessed, 
      and multivariable linear regression was performed. RESULTS: Eleven children were 
      enrolled (mean age, 10.7 +/- 3.9 years). Treatment included enucleation (8 children 
      [73%]) and chemotherapy (10 [91%]). Of the 11, one participant was unable to 
      complete testing of saccades, and another was unable to complete contrast 
      sensitivity testing. Decreased saccade parameters (velocity, latency, or 
      accuracy) and impaired contrast sensitivity were observed in all 10 participants 
      who underwent visual testing. Multivariable analysis revealed that worse logMAR 
      visual acuity (B, -4.54 [-6.8, -2.2]; P = 0.004) and bilateral disease (B, -3.9 
      [-6.4, -1.4]; P = 0.009) were associated with worse contrast sensitivity. 
      Germline disease was associated with decreased vertical saccade accuracy (P = 
      0.02). CONCLUSIONS: Decreased contrast sensitivity and impaired saccades were 
      universally observed in this cohort of RB survivors. Comprehensive visual 
      evaluation should be considered for all RB survivors to provide optimal 
      rehabilitative services for these patients.
CI  - Copyright (c) 2023 American Association for Pediatric Ophthalmology and Strabismus. 
      Published by Elsevier Inc. All rights reserved.
FAU - Reynolds, Margaret
AU  - Reynolds M
AD  - Washington University / Saint Louis Children's Hospital, Saint Louis, Missouri. 
      Electronic address: Margaret.reynolds@wustl.edu.
FAU - Wise, Jacob
AU  - Wise J
AD  - Washington University / Saint Louis Children's Hospital, Saint Louis, Missouri.
FAU - Wu, Tiffany
AU  - Wu T
AD  - Washington University / Saint Louis Children's Hospital, Saint Louis, Missouri.
FAU - Malone, Sara
AU  - Malone S
AD  - Washington University / Saint Louis Children's Hospital, Saint Louis, Missouri.
FAU - Al Badawi, Amer
AU  - Al Badawi A
AD  - Washington University / Saint Louis Children's Hospital, Saint Louis, Missouri.
FAU - King, Allison
AU  - King A
AD  - Washington University / Saint Louis Children's Hospital, Saint Louis, Missouri.
FAU - Gordon, Mae
AU  - Gordon M
AD  - Washington University / Saint Louis Children's Hospital, Saint Louis, Missouri.
FAU - Lueder, Gregg
AU  - Lueder G
AD  - Washington University / Saint Louis Children's Hospital, Saint Louis, Missouri.
FAU - Hayashi, Robert
AU  - Hayashi R
AD  - Washington University / Saint Louis Children's Hospital, Saint Louis, Missouri.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230712
PL  - United States
TA  - J AAPOS
JT  - Journal of AAPOS : the official publication of the American Association for 
      Pediatric Ophthalmology and Strabismus
JID - 9710011
SB  - IM
MH  - Humans
MH  - Child
MH  - Adolescent
MH  - *Retinoblastoma/therapy
MH  - Cross-Sectional Studies
MH  - Visual Acuity
MH  - Survivors
MH  - *Retinal Neoplasms/therapy
EDAT- 2023/07/14 13:06
MHDA- 2023/09/11 06:42
CRDT- 2023/07/13 19:29
PHST- 2023/04/17 00:00 [received]
PHST- 2023/06/21 00:00 [accepted]
PHST- 2023/09/11 06:42 [medline]
PHST- 2023/07/14 13:06 [pubmed]
PHST- 2023/07/13 19:29 [entrez]
AID - S1091-8531(23)00133-7 [pii]
AID - 10.1016/j.jaapos.2023.06.003 [doi]
PST - ppublish
SO  - J AAPOS. 2023 Aug;27(4):188.e1-188.e6. doi: 10.1016/j.jaapos.2023.06.003. Epub 
      2023 Jul 12.