PMID- 37443630
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 13
IP  - 13
DP  - 2023 Jun 30
TI  - Pretreatment CT Texture Parameters as Predictive Biomarkers of Progression-Free 
      Survival in Follicular Lymphoma Treated with Immunochemotherapy and Rituximab 
      Maintenance.
LID - 10.3390/diagnostics13132237 [doi]
LID - 2237
AB  - The purpose of this study was to determine whether texture analysis features 
      present on pretreatment unenhanced computed tomography (CT) images, derived from 
      18F-fluorodeoxyglucose positron emission/computed tomography (18-FDG PET/CT), can 
      predict progression-free survival (PFS), progression-free survival at 24 months 
      (PFS 24), time to next treatment (TTNT), and overall survival in patients with 
      high-tumor-burden follicular lymphoma treated with immunochemotherapy and 
      rituximab maintenance. Seventy-two patients with follicular lymphoma were 
      retrospectively included. Texture analysis was performed on unenhanced CT images 
      extracted from 18-FDG PET/CT examinations that were obtained within one month 
      before treatment. Skewness at a fine texture scale (SSF = 2) was an independent 
      predictor of PFS (hazard ratio = 3.72 (95% CI: 1.15, 12.11), p = 0.028), PFS 24 
      (hazard ratio = 13.38; 95% CI: 1.29, 138.13; p = 0.029), and TTNT (hazard ratio = 
      5.11; 95% CI: 1.18, 22.13; p = 0.029). Skewness values above -0.015 at SSF = 2 
      were significantly associated with lower PFS, PFS 24, and TTNT. Kurtosis without 
      filtration was an independent predictor of PFS (SSF = 0; HR = 1.22 (95% CI: 1.04, 
      1.44), p = 0.013), and TTNT (SSF = 0; hazard ratio = 1.23; 95% CI: 1.04, 1.46; p 
      = 0.013). This study shows that pretreatment unenhanced CT texture 
      analysis-derived tumor skewness and kurtosis may be used as predictive biomarkers 
      of PFS and TTNT in patients with high-tumor-burden follicular lymphoma treated 
      with immunochemotherapy and rituximab maintenance.
FAU - Durot, Carole
AU  - Durot C
AD  - Department of Radiology, Reims University Hospital, 45 Rue Cognacq-Jay, 51092 
      Reims, France.
FAU - Durot, Eric
AU  - Durot E
AUID- ORCID: 0000-0003-3463-0089
AD  - Department of Hematology, Reims University Hospital, 45 Rue Cognacq-Jay, 51092 
      Reims, France.
FAU - Mule, Sebastien
AU  - Mule S
AUID- ORCID: 0000-0002-6896-6149
AD  - Department of Radiology, Henri Mondor University Hospital, 51 Avenue du Marechal 
      de Lattre de Tassigny, 94010 Creteil, France.
AD  - Faculte de Medecine, Universite Paris-Est Creteil, 61 Avenue du General de 
      Gaulle, 94000 Creteil, France.
FAU - Morland, David
AU  - Morland D
AUID- ORCID: 0000-0001-8738-4841
AD  - Department of Nuclear Medicine, Godinot Institute, 1 Rue du General Koenig, 51100 
      Reims, France.
AD  - CReSTIC, EA 3804, University of Reims Champagne-Ardenne, UFR Moulin de la Housse, 
      51867 Reims, France.
FAU - Godard, Francois
AU  - Godard F
AD  - Department of Radiology, Henri Mondor University Hospital, 51 Avenue du Marechal 
      de Lattre de Tassigny, 94010 Creteil, France.
FAU - Quinquenel, Anne
AU  - Quinquenel A
AD  - Department of Hematology, Reims University Hospital, 45 Rue Cognacq-Jay, 51092 
      Reims, France.
FAU - Delmer, Alain
AU  - Delmer A
AUID- ORCID: 0000-0002-1430-2574
AD  - Department of Hematology, Reims University Hospital, 45 Rue Cognacq-Jay, 51092 
      Reims, France.
FAU - Soyer, Philippe
AU  - Soyer P
AUID- ORCID: 0000-0002-5055-1682
AD  - Department of Radiology, Hopital Cochin, AP-HP, 27 Rue du Faubourg Saint-Jacques, 
      75014 Paris, France.
AD  - Faculte de Medecine, Universite Paris Cite, 75006 Paris, France.
FAU - Hoeffel, Christine
AU  - Hoeffel C
AD  - Department of Radiology, Reims University Hospital, 45 Rue Cognacq-Jay, 51092 
      Reims, France.
AD  - CReSTIC, EA 3804, University of Reims Champagne-Ardenne, UFR Moulin de la Housse, 
      51867 Reims, France.
LA  - eng
PT  - Journal Article
DEP - 20230630
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC10340740
OTO - NOTNLM
OT  - X-ray computed
OT  - follicular lymphoma
OT  - positron emission tomography
OT  - tomography
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/14 13:07
MHDA- 2023/07/14 13:08
PMCR- 2023/06/30
CRDT- 2023/07/14 01:01
PHST- 2023/05/03 00:00 [received]
PHST- 2023/06/20 00:00 [revised]
PHST- 2023/06/26 00:00 [accepted]
PHST- 2023/07/14 13:08 [medline]
PHST- 2023/07/14 13:07 [pubmed]
PHST- 2023/07/14 01:01 [entrez]
PHST- 2023/06/30 00:00 [pmc-release]
AID - diagnostics13132237 [pii]
AID - diagnostics-13-02237 [pii]
AID - 10.3390/diagnostics13132237 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2023 Jun 30;13(13):2237. doi: 10.3390/diagnostics13132237.