PMID- 37445273
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 13
DP  - 2023 Jun 23
TI  - Effective and Secure Closure after Duodenal Endoscopic Submucosal Dissection: 
      Combination of Endoscopic Ligation with O-Ring Closure and Over-the-Scope Clip.
LID - 10.3390/jcm12134238 [doi]
LID - 4238
AB  - Duodenal endoscopic submucosal dissection (ESD) is associated with high 
      incidences of intraoperative complications and delayed adverse events (AEs). 
      Delayed AEs can be reduced by closing the post-ESD defects. We developed a new 
      method of closure after duodenal ESD, combining endoscopic ligation with O-ring 
      closure (E-LOC) with an over-the-scope clip (OTSC) (Band OTSC; B-OTSC). Here, we 
      conducted a single-center, retrospective, observational study to investigate the 
      efficacy and safety of the B-OTSC method for preventing delayed AEs in patients 
      undergoing duodenal ESD. The study included nine patients with superficial 
      nonpapillary duodenal epithelial tumors who underwent ESD and were closed with 
      B-OTSC from February 2021 to February 2023. There were no delayed AEs (0%), the 
      mean (+/- standard deviation) closure time was 53 +/- 21.6 min, the complete closure 
      rate was 100%, and the mean hospital stay was 7.8 +/- 1.8 days. The sustained 
      closure rates at postoperative days 3 and 7 were 88.9% and 88.9%, respectively. 
      The historical analysis indicated a significant difference in cost between B-OTSC 
      and conventional OTSC (p < 0.01). In conclusion, B-OTSC was a safe, secure, and 
      cost-effective method of closure after duodenal ESD, even in patients with 
      post-ESD defects of more than half the circumference.
FAU - Nakatani, Kaho
AU  - Nakatani K
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
AD  - Department of General Internal Medicine, Faculty of Medicine, Kagawa University, 
      Takamatsu 761-0793, Japan.
FAU - Kobara, Hideki
AU  - Kobara H
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
FAU - Nishiyama, Noriko
AU  - Nishiyama N
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
FAU - Fujihara, Shintaro
AU  - Fujihara S
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
FAU - Tada, Naoya
AU  - Tada N
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
FAU - Koduka, Kazuhiro
AU  - Koduka K
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
FAU - Matsui, Takanori
AU  - Matsui T
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
FAU - Chiyo, Taiga
AU  - Chiyo T
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
FAU - Kobayashi, Nobuya
AU  - Kobayashi N
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
FAU - Yachida, Tatsuo
AU  - Yachida T
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
FAU - Tani, Joji
AU  - Tani J
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
FAU - Morishita, Asahiro
AU  - Morishita A
AUID- ORCID: 0000-0002-0760-3045
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
FAU - Isomoto, Hajime
AU  - Isomoto H
AD  - Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori 
      University, Tottori 683-8504, Japan.
FAU - Masaki, Tsutomu
AU  - Masaki T
AD  - Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa 
      University, Takamatsu 761-0793, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230623
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10342600
OTO - NOTNLM
OT  - duodenal endoscopic submucosal dissection
OT  - endoscopic ligation with O-ring closure
OT  - over-the-scope clip
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/14 13:07
MHDA- 2023/07/14 13:08
PMCR- 2023/06/23
CRDT- 2023/07/14 01:10
PHST- 2023/04/16 00:00 [received]
PHST- 2023/06/07 00:00 [revised]
PHST- 2023/06/20 00:00 [accepted]
PHST- 2023/07/14 13:08 [medline]
PHST- 2023/07/14 13:07 [pubmed]
PHST- 2023/07/14 01:10 [entrez]
PHST- 2023/06/23 00:00 [pmc-release]
AID - jcm12134238 [pii]
AID - jcm-12-04238 [pii]
AID - 10.3390/jcm12134238 [doi]
PST - epublish
SO  - J Clin Med. 2023 Jun 23;12(13):4238. doi: 10.3390/jcm12134238.