PMID- 37445411
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 13
DP  - 2023 Jun 29
TI  - Adipokines as Predictive Biomarkers for Training Adaptation in Subjects with 
      Multimorbidity-A Hypothesis-Generating Study.
LID - 10.3390/jcm12134376 [doi]
LID - 4376
AB  - BACKGROUND: Physical exercise exerts a positive effect on many chronic 
      conditions, specifically lifestyle-related diseases such as overweight and 
      obesity, type 2 diabetes mellitus (T2DM), cardiovascular conditions and 
      osteoarthritis (OA). As a result of common risk factors, most of these patients 
      present with multiple conditions. Exercise- and disease-related biomarkers, such 
      as adipokines, are emerging tools in training supervision and regulation; 
      however, their significance in subjects with multimorbidities is unknown. 
      SUBJECTS AND METHODS: To address this issue, adipokines leptin, adiponectin and 
      resistin were assessed in a cohort of subjects with multimorbidities (n = 39) 
      presenting with at least two of the abovementioned conditions or relevant risk 
      factors before and after a six-month exercise and lifestyle intervention program 
      ('MultiPill-Exercise'), and correlated with training adaptation, namely changes 
      in relative maximum oxygen uptake (V.O2max). RESULTS: There was a significant 
      negative correlation between baseline leptin concentrations and training effect 
      for relative V.O2max (after three months: rho = -0.54, p = 0.020 *; after six 
      months: rho = -0.45, p = 0.013 *), with baseline leptin explaining 35% of the 
      variance in delta relative V.O2max after three months and 23% after six months. 
      CONCLUSIONS: Leptin might be a suitable surrogate biomarker in the context of 
      exercise-based lifestyle intervention programs in subjects with multimorbidity.
FAU - Maturana, Felipe Mattioni
AU  - Maturana FM
AUID- ORCID: 0000-0002-4221-6104
AD  - Department of Sports Medicine, University Hospital Tubingen, Hoppe-Seyler-Str. 6, 
      D-72076 Tubingen, Germany.
FAU - Rolf, Rebecca
AU  - Rolf R
AD  - Department of Sports Medicine, University Hospital Tubingen, Hoppe-Seyler-Str. 6, 
      D-72076 Tubingen, Germany.
FAU - Schweda, Simone
AU  - Schweda S
AUID- ORCID: 0000-0001-5827-2664
AD  - Department of Sports Medicine, University Hospital Tubingen, Hoppe-Seyler-Str. 6, 
      D-72076 Tubingen, Germany.
FAU - Reimer, Max
AU  - Reimer M
AD  - Department of Sports Medicine, University Hospital Tubingen, Hoppe-Seyler-Str. 6, 
      D-72076 Tubingen, Germany.
FAU - Widmann, Manuel
AU  - Widmann M
AD  - Department of Sports Medicine, University Hospital Tubingen, Hoppe-Seyler-Str. 6, 
      D-72076 Tubingen, Germany.
FAU - Burgstahler, Christof
AU  - Burgstahler C
AD  - Department of Sports Medicine, University Hospital Tubingen, Hoppe-Seyler-Str. 6, 
      D-72076 Tubingen, Germany.
AD  - Interfaculty Research Institute for Sport and Physical Activity, Eberhard Karls 
      University of Tubingen, D-72076 Tubingen, Germany.
FAU - Niess, Andreas M
AU  - Niess AM
AD  - Department of Sports Medicine, University Hospital Tubingen, Hoppe-Seyler-Str. 6, 
      D-72076 Tubingen, Germany.
AD  - Interfaculty Research Institute for Sport and Physical Activity, Eberhard Karls 
      University of Tubingen, D-72076 Tubingen, Germany.
FAU - Krauss, Inga
AU  - Krauss I
AUID- ORCID: 0000-0001-6818-6276
AD  - Department of Sports Medicine, University Hospital Tubingen, Hoppe-Seyler-Str. 6, 
      D-72076 Tubingen, Germany.
AD  - Interfaculty Research Institute for Sport and Physical Activity, Eberhard Karls 
      University of Tubingen, D-72076 Tubingen, Germany.
FAU - Munz, Barbara
AU  - Munz B
AUID- ORCID: 0000-0002-4582-6119
AD  - Department of Sports Medicine, University Hospital Tubingen, Hoppe-Seyler-Str. 6, 
      D-72076 Tubingen, Germany.
AD  - Interfaculty Research Institute for Sport and Physical Activity, Eberhard Karls 
      University of Tubingen, D-72076 Tubingen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20230629
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10342946
OTO - NOTNLM
OT  - adipokines
OT  - leptin
OT  - multimorbidity
OT  - obesity
OT  - physical exercise
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2023/07/14 13:06
MHDA- 2023/07/14 13:07
PMCR- 2023/06/29
CRDT- 2023/07/14 01:11
PHST- 2023/05/21 00:00 [received]
PHST- 2023/06/18 00:00 [revised]
PHST- 2023/06/27 00:00 [accepted]
PHST- 2023/07/14 13:07 [medline]
PHST- 2023/07/14 13:06 [pubmed]
PHST- 2023/07/14 01:11 [entrez]
PHST- 2023/06/29 00:00 [pmc-release]
AID - jcm12134376 [pii]
AID - jcm-12-04376 [pii]
AID - 10.3390/jcm12134376 [doi]
PST - epublish
SO  - J Clin Med. 2023 Jun 29;12(13):4376. doi: 10.3390/jcm12134376.