PMID- 37445644
OWN - NLM
STAT- MEDLINE
DCOM- 20230717
LR  - 20230718
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 13
DP  - 2023 Jun 21
TI  - Molecular Mapping of Allergen Exposome among Different Atopic Phenotypes.
LID - 10.3390/ijms241310467 [doi]
LID - 10467
AB  - Climate change and exposure to environmental pollutants play a key role in the 
      onset and aggravation of allergic diseases. As different climate-dependent 
      patterns of molecular immunoglobulin E (IgE) reactivity have been regionally 
      described, we sought to investigate the evolving allergen exposome in distinctive 
      allergic phenotypes and subtropical weather conditions through a Precision 
      Allergy Molecular Diagnosis (PAMD@) model. Concurrent sensitization to several 
      house dust mites (HDM) and storage mite molecules were broadly dominant in the 
      investigated cohort, followed by the major cat allergen Fel d 1, and regardless 
      of the basal allergic disease. Although a complex repertoire of allergens was 
      recognized, a steadily increasing number of IgE binding molecules was associated 
      with the complexity of the underlying atopic disease. Besides the highly 
      prevalent IgE responses to major HDM allergens, Der p 21, Der p 5, and Der p 7 
      also showed up as serodominant molecules, especially in subjects bothered by 
      asthma and atopic dermatitis. The accurate characterization of the external 
      exposome at the molecular level and their putative role as clinically relevant 
      allergens is essential to elucidate the phenotypic diversity of atopic disease in 
      terms of personalized diagnosis and therapy.
FAU - Gonzalez-Perez, Ruperto
AU  - Gonzalez-Perez R
AUID- ORCID: 0000-0002-6664-0276
AD  - Allergy Department, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
AD  - Severe Asthma Unit, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
FAU - Poza-Guedes, Paloma
AU  - Poza-Guedes P
AUID- ORCID: 0000-0001-8516-6648
AD  - Allergy Department, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
AD  - Severe Asthma Unit, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
FAU - Pineda, Fernando
AU  - Pineda F
AUID- ORCID: 0000-0001-8366-9145
AD  - Inmunotek SL Laboratories, 28805 Madrid, Spain.
FAU - Galan, Tania
AU  - Galan T
AD  - Inmunotek SL Laboratories, 28805 Madrid, Spain.
FAU - Mederos-Luis, Elena
AU  - Mederos-Luis E
AUID- ORCID: 0000-0001-5298-6447
AD  - Allergy Department, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
FAU - Abel-Fernandez, Eva
AU  - Abel-Fernandez E
AUID- ORCID: 0000-0002-5309-2434
AD  - Inmunotek SL Laboratories, 28805 Madrid, Spain.
FAU - Martinez, Maria Jose
AU  - Martinez MJ
AD  - Inmunotek SL Laboratories, 28805 Madrid, Spain.
FAU - Sanchez-Machin, Inmaculada
AU  - Sanchez-Machin I
AD  - Allergy Department, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
AD  - Allergen Immunotherapy Unit, Hospital Universitario de Canarias, 38320 Tenerife, 
      Spain.
LA  - eng
GR  - grant number OA17/042/: This research was funded by Fundacion Canaria Instituto 
      de Investigacion Sanitaria de Cana-rias (FIISC), Servicio Canario de Salud./
PT  - Journal Article
DEP - 20230621
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Antigens, Dermatophagoides)
SB  - IM
MH  - Humans
MH  - Allergens
MH  - *Exposome
MH  - *Hypersensitivity
MH  - *Dermatitis, Atopic/diagnosis
MH  - Phenotype
MH  - Immunoglobulin E
MH  - Antigens, Dermatophagoides
PMC - PMC10341948
OTO - NOTNLM
OT  - airborne allergens
OT  - allergic rhinitis
OT  - asthma
OT  - atopic dermatitis
OT  - atopy
OT  - climate change
OT  - exposome
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2023/07/14 13:06
MHDA- 2023/07/17 06:42
PMCR- 2023/06/21
CRDT- 2023/07/14 01:12
PHST- 2023/04/29 00:00 [received]
PHST- 2023/06/18 00:00 [revised]
PHST- 2023/06/20 00:00 [accepted]
PHST- 2023/07/17 06:42 [medline]
PHST- 2023/07/14 13:06 [pubmed]
PHST- 2023/07/14 01:12 [entrez]
PHST- 2023/06/21 00:00 [pmc-release]
AID - ijms241310467 [pii]
AID - ijms-24-10467 [pii]
AID - 10.3390/ijms241310467 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Jun 21;24(13):10467. doi: 10.3390/ijms241310467.