PMID- 37446301
OWN - NLM
STAT- MEDLINE
DCOM- 20230717
LR  - 20230718
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 13
DP  - 2023 Jul 5
TI  - IL-18 in Autoinflammatory Diseases: Focus on Adult Onset Still Disease and 
      Macrophages Activation Syndrome.
LID - 10.3390/ijms241311125 [doi]
LID - 11125
AB  - Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine that is involved in 
      various innate and adaptive immune processes related to infection, inflammation, 
      and autoimmunity. Therefore, it is described as a key mediator of 
      autoinflammatory diseases associated with the development of macrophage 
      activation syndrome (MAS), including systemic juvenile idiopathic arthritis and 
      adult-onset Still's disease. This review focuses on the role of IL-18 in 
      inflammatory responses, placing emphasis on autoinflammatory diseases associated 
      with chronic excess of serum IL-18, which correlate with clinical and biological 
      signs of the disease. Therefore, it is useful for the diagnosis and monitoring of 
      disease activity. Researchers are currently investigating IL-18's role as a 
      therapeutic target for the treatment of inflammatory diseases. The inhibition of 
      IL-18 signaling through recombinant human IL-18BP (IL-18 binding protein) seems 
      to be an effective therapeutic strategy, though further studies are necessary to 
      clarify its importance as a therapeutic target.
FAU - Baggio, Chiara
AU  - Baggio C
AD  - Rheumatology Unit, Department of Medicine, University of Padova, 35128 Padova, 
      Italy.
FAU - Bindoli, Sara
AU  - Bindoli S
AD  - Rheumatology Unit, Department of Medicine, University of Padova, 35128 Padova, 
      Italy.
FAU - Guidea, Irina
AU  - Guidea I
AD  - Rheumatology Unit, Department of Medicine, University of Padova, 35128 Padova, 
      Italy.
FAU - Doria, Andrea
AU  - Doria A
AUID- ORCID: 0000-0003-0548-4983
AD  - Rheumatology Unit, Department of Medicine, University of Padova, 35128 Padova, 
      Italy.
FAU - Oliviero, Francesca
AU  - Oliviero F
AUID- ORCID: 0000-0002-4958-5105
AD  - Rheumatology Unit, Department of Medicine, University of Padova, 35128 Padova, 
      Italy.
FAU - Sfriso, Paolo
AU  - Sfriso P
AUID- ORCID: 0000-0001-6432-7174
AD  - Rheumatology Unit, Department of Medicine, University of Padova, 35128 Padova, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230705
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Interleukin-18/metabolism
MH  - *Still's Disease, Adult-Onset/diagnosis/drug therapy
MH  - *Macrophage Activation Syndrome/diagnosis
MH  - *Hereditary Autoinflammatory Diseases
MH  - Macrophages/metabolism
PMC - PMC10342495
OTO - NOTNLM
OT  - adult-onset Still's disease
OT  - autoinflammatory diseases
OT  - interleukin (IL)-18
OT  - macrophage activation syndrome
COIS- A.D. received consultancy fees from GSK, Eli Lilly, AstraZeneca, and Otsuka. P.S. 
      received grants from Novartis and Sobi. The other authors declare no conflict of 
      interest.
EDAT- 2023/07/14 13:08
MHDA- 2023/07/17 06:42
PMCR- 2023/07/05
CRDT- 2023/07/14 01:16
PHST- 2023/06/16 00:00 [received]
PHST- 2023/06/30 00:00 [revised]
PHST- 2023/07/03 00:00 [accepted]
PHST- 2023/07/17 06:42 [medline]
PHST- 2023/07/14 13:08 [pubmed]
PHST- 2023/07/14 01:16 [entrez]
PHST- 2023/07/05 00:00 [pmc-release]
AID - ijms241311125 [pii]
AID - ijms-24-11125 [pii]
AID - 10.3390/ijms241311125 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Jul 5;24(13):11125. doi: 10.3390/ijms241311125.