PMID- 37450032
OWN - NLM
STAT- MEDLINE
DCOM- 20230912
LR  - 20230922
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 43
IP  - 11
DP  - 2023 Nov
TI  - Clinical significance of possible HLA biomarkers in axial spondyloarthritis 
      beyond HLA-B27 positivity.
PG  - 2073-2079
LID - 10.1007/s00296-023-05391-6 [doi]
AB  - The aim of this study is to compare four forms of axial spondyloarthritis 
      (axSpA): non-radiographic axial spondyloarthritis (nr-axSpA), ankylosing 
      spondylitis (AS), non-radiographic axial psoriatic arthritis (nr-axPsA) and 
      radiographic axial psoriatic arthritis (r-axPsA). In a cross-sectional 
      retrospective study, gender difference, human leukocyte antigen (HLA) typing, 
      laboratory C-reactive protein (CRP) and erythrocyte sedimentation (SE) values, 
      and radiographic and magnetic resonance scans were analyzed. One hundred and 
      thirty-seven patients were included in the study: 45 AS, 51 nr-axSpA, 32 r-axPsA 
      and 9 nr-axPsA; 74 women and 63 men. Most of the gender, laboratory and 
      radiological findings confirmed the results of previously conducted studies about 
      each group of the investigated axSpA. The key findings of our study are the newly 
      detected findings of HLA typing beyond HLA-27 positivity: HLA-DR16 in AS, 
      HLA-DR11 in nr-axSpA, HLA-B13, HLA-B57, HLA-Cw12 and HLA-DR7 in r-axPsA, and 
      HLA-B18 in nr-axPsA. Our study also confirmed some of the results of previously 
      conducted studies on predominant genes of HLA typing in axSpA: HLA-B27 in AS, 
      HLA-B39 and HLA-Cw6 in r-axPsA, and HLA-Cw7 in nr-axPsA. Important conclusions 
      about the nr-axPsA group cannot be drawn because of the very small number of 
      subjects included in this group of axSpA. Our results suggest that the newly 
      detected HLA typing findings beyond HLA-B27 positivity could be possible 
      biomarkers of early detection of axSpA, but further studies on larger samples are 
      needed.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Segota, Adelmo
AU  - Segota A
AUID- ORCID: 0009-0004-0775-366X
AD  - School of Medicine Rijeka, Clinical Hospital Centre Rijeka, University Department 
      of Physical and Rehabilitation Medicine, Kresimirova 42, 51000, Rijeka, Croatia. 
      adellmos@yahoo.com.
FAU - Schnurrer-Luke-Vrbanic, Tea
AU  - Schnurrer-Luke-Vrbanic T
AUID- ORCID: 0000-0002-9161-4328
AD  - School of Medicine Rijeka, Clinical Hospital Centre Rijeka, University Department 
      of Physical and Rehabilitation Medicine, Kresimirova 42, 51000, Rijeka, Croatia.
FAU - Avancini-Dobrovic, Viviana
AU  - Avancini-Dobrovic V
AUID- ORCID: 0000-0003-4359-4868
AD  - School of Medicine Rijeka, Clinical Hospital Centre Rijeka, University Department 
      of Physical and Rehabilitation Medicine, Kresimirova 42, 51000, Rijeka, Croatia.
FAU - Miric, Filip
AU  - Miric F
AUID- ORCID: 0000-0001-6053-1469
AD  - Clinic of Internal Medicine, School of Medicine Rijeka, Clinical Hospital Centre 
      Rijeka, University Department of Rheumatology and Clinical Immunology, 
      Kresimirova 42, 51000, Rijeka, Croatia.
LA  - eng
PT  - Journal Article
DEP - 20230714
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Spondylarthritis/diagnosis
MH  - HLA-B27 Antigen/genetics
MH  - Retrospective Studies
MH  - *Arthritis, Psoriatic
MH  - *Non-Radiographic Axial Spondyloarthritis
MH  - Cross-Sectional Studies
MH  - Clinical Relevance
MH  - *Spondylitis, Ankylosing/diagnosis
MH  - Biomarkers
OTO - NOTNLM
OT  - Ankylosing spondylitis
OT  - Axial psoriatic arthritis
OT  - HLA-B27 negative
OT  - Non-radiographic axial spondyloarthritis
EDAT- 2023/07/14 13:08
MHDA- 2023/09/12 06:41
CRDT- 2023/07/14 11:05
PHST- 2023/04/25 00:00 [received]
PHST- 2023/06/29 00:00 [accepted]
PHST- 2023/09/12 06:41 [medline]
PHST- 2023/07/14 13:08 [pubmed]
PHST- 2023/07/14 11:05 [entrez]
AID - 10.1007/s00296-023-05391-6 [pii]
AID - 10.1007/s00296-023-05391-6 [doi]
PST - ppublish
SO  - Rheumatol Int. 2023 Nov;43(11):2073-2079. doi: 10.1007/s00296-023-05391-6. Epub 
      2023 Jul 14.