PMID- 37450928
OWN - NLM
STAT- MEDLINE
DCOM- 20240509
LR  - 20240511
IS  - 2152-5250 (Electronic)
IS  - 2152-5250 (Linking)
VI  - 15
IP  - 3
DP  - 2024 May 7
TI  - Mitochondrial Dysfunction of Astrocytes Mediates Lipid Accumulation in Temporal 
      Lobe Epilepsy.
PG  - 1289-1295
LID - 10.14336/AD.2023.0624 [doi]
AB  - Lipid-accumulated reactive astrocytes (LARAs) have recently been confirmed to be 
      a pivotal cell type present in temporal lobe epilepsy (TLE) lesions. These cells 
      not only induce anomalous lipid accumulation within the epileptic foci but also 
      decrease the seizure threshold by employing upregulated activation of the 
      adenosine A2A receptor (A(2A)R). Furthermore, disturbances in mitochondrial 
      oxidative phosphorylation (OxPhos) have been noted as significant drivers of 
      lipid accumulation in astrocytes. Moreover, the deficiency of OxPhos in 
      astrocytes can induce severe neuroinflammation, which can worsen the progression 
      of TLE. Accordingly, further exploration of the correlation between mitochondrial 
      dysfunction, LARAs-mediated lipid accumulation, and A(2A)R activation within 
      epilepsy lesions is warranted. It could potentially elucidate the vital role of 
      mitochondrial dysfunction in the pathogenesis of TLE.
FAU - Su, Yang
AU  - Su Y
AD  - Department of Laboratory Medicine, West China Hospital of Sichuan University, 
      China.
FAU - Tang, Meng
AU  - Tang M
AD  - Department of Laboratory Medicine, West China Hospital of Sichuan University, 
      China.
FAU - Wang, Minjin
AU  - Wang M
AD  - Department of Laboratory Medicine, West China Hospital of Sichuan University, 
      China.
AD  - Department of Neurology, West China Hospital of Sichuan University, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20240507
PL  - United States
TA  - Aging Dis
JT  - Aging and disease
JID - 101540533
RN  - 0 (Receptor, Adenosine A2A)
SB  - IM
MH  - *Epilepsy, Temporal Lobe/metabolism/pathology
MH  - *Astrocytes/metabolism/pathology
MH  - Humans
MH  - *Mitochondria/metabolism/pathology
MH  - *Lipid Metabolism
MH  - Oxidative Phosphorylation
MH  - Animals
MH  - Receptor, Adenosine A2A/metabolism/genetics
PMC - PMC11081153
COIS- Conflicts of interest The authors declare that there is no conflict of interest 
      associated with the study.
EDAT- 2023/07/14 19:08
MHDA- 2024/05/10 05:43
PMCR- 2024/05/07
CRDT- 2023/07/14 17:25
PHST- 2023/05/18 00:00 [received]
PHST- 2023/06/24 00:00 [accepted]
PHST- 2024/05/10 05:43 [medline]
PHST- 2023/07/14 19:08 [pubmed]
PHST- 2023/07/14 17:25 [entrez]
PHST- 2024/05/07 00:00 [pmc-release]
AID - AD.2023.0624 [pii]
AID - ad-15-3-1289 [pii]
AID - 10.14336/AD.2023.0624 [doi]
PST - epublish
SO  - Aging Dis. 2024 May 7;15(3):1289-1295. doi: 10.14336/AD.2023.0624.