PMID- 37451674
OWN - NLM
STAT- MEDLINE
DCOM- 20240320
LR  - 20240422
IS  - 1943-569X (Electronic)
IS  - 0003-1488 (Linking)
VI  - 261
IP  - 11
DP  - 2023 Nov 1
TI  - Breed, smaller weight, and multiple injections are associated with increased 
      adverse event reports within three days following canine vaccine administration.
PG  - 1653-1659
LID - 10.2460/javma.23.03.0181 [doi]
AB  - OBJECTIVE: To evaluate patient and vaccine factors associated with adverse events 
      (AEs) recorded within 3 days of vaccine administration in a large cohort of dogs. 
      ANIMALS: 4,654,187 dogs vaccinated in 16,087,455 office visits in a 5-year period 
      at 1,119 hospitals of a corporate practice. METHODS: Electronic medical records 
      of dogs vaccinated between January 1, 2016, and December 31, 2020, were searched 
      for diagnoses of possible AEs recorded within 3 days of administration of 
      vaccines without concurrent injectable heartworm preventative. Patient risk 
      factors (age, sex, breed, and weight) and number and type of vaccine were 
      extracted from records. ORs (and 95% CIs) for risk factors were estimated via 
      multivariable logistic regression mixed models with patient as a random effect. 
      RESULTS: AEs were recorded following 31,197 vaccination visits (0.19%, or 
      19.4/10,000 visits). Reported AE rates increased from 1 to 4 vaccines 
      administered and among individual vaccines were greatest for rabies vaccine. AE 
      rate was generally inversely related to body weight, with largest rates in dogs </= 
      5 kg. The largest AE rates were noted in French Bulldogs and Dachshunds (ORs > 4 
      compared to mixed-breed dogs). CLINICAL RELEVANCE: Risk factor information can be 
      used to update vaccination protocols and client communication. Breed differences 
      may indicate genetics as the primary risk factor for adverse vaccine reactions 
      following vaccinations.
FAU - Moore, George E
AU  - Moore GE
AD  - 1College of Veterinary Medicine, Purdue University, West Lafayette, IN.
FAU - Morrison, JoAnn
AU  - Morrison J
AD  - 2Banfield Pet Hospital, Vancouver, WA.
FAU - Saito, Emi K
AU  - Saito EK
AD  - 2Banfield Pet Hospital, Vancouver, WA.
FAU - Spofford, Nathaniel
AU  - Spofford N
AD  - 2Banfield Pet Hospital, Vancouver, WA.
FAU - Yang, Mike
AU  - Yang M
AD  - 2Banfield Pet Hospital, Vancouver, WA.
LA  - eng
PT  - Journal Article
DEP - 20230714
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
RN  - 0 (Vaccines)
SB  - IM
MH  - Humans
MH  - Dogs
MH  - Animals
MH  - Vaccination/adverse effects/veterinary
MH  - *Vaccines
MH  - Risk Factors
MH  - *Drug-Related Side Effects and Adverse Reactions/veterinary
MH  - *Dog Diseases/etiology
EDAT- 2023/07/15 10:42
MHDA- 2024/03/20 06:45
CRDT- 2023/07/14 19:33
PHST- 2023/04/07 00:00 [received]
PHST- 2023/06/22 00:00 [accepted]
PHST- 2024/03/20 06:45 [medline]
PHST- 2023/07/15 10:42 [pubmed]
PHST- 2023/07/14 19:33 [entrez]
AID - 10.2460/javma.23.03.0181 [doi]
PST - epublish
SO  - J Am Vet Med Assoc. 2023 Jul 14;261(11):1653-1659. doi: 10.2460/javma.23.03.0181. 
      Print 2023 Nov 1.