PMID- 37451971
OWN - NLM
STAT- MEDLINE
DCOM- 20230908
LR  - 20230908
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 47
IP  - 3
DP  - 2023 Sep
TI  - Heavy metals and diminished ovarian reserve: single-exposure and mixture analyses 
      amongst women consulting in French fertility centres.
PG  - 103241
LID - S1472-6483(23)00340-1 [pii]
LID - 10.1016/j.rbmo.2023.05.013 [doi]
AB  - RESEARCH QUESTION: Do heavy metals affect the risk of diminished ovarian reserve 
      (DOR) in women of reproductive age? DESIGN: A total of 139 cases and 153 controls 
      were included between 2016 and 2020. The participants were aged between 18 and 40 
      years and attended consultations for couple infertility in one of four fertility 
      centres in western France. Cases of DOR were defined as women with an antral 
      follicle count less than 7, anti-Mullerian hormone levels 1.1 ng/ml or less, or 
      both. Controls were frequency matched on age groups and centres, and were women 
      with normal ovarian reserve evaluations, no malformations and menstrual cycles 
      between 26 and 35 days. Heavy metals (lead, mercury, cadmium and chromium) were 
      measured in whole blood at inclusion. Single-exposure associations were examined 
      with multivariable logistic regressions adjusted on potential confounders. 
      Mixture effects were investigated with quantile g-computation and Bayesian kernel 
      machine regression (BKMR). RESULTS: Chromium as a continuous exposure was 
      significantly associated with DOR in unadjusted models (OR 2.07, 95% CI 1.04 to 
      4.13) but the association was no longer significant when confounders were 
      controlled for (adjusted OR 2.75, 95% CI 0.88 to 8.60). Similarly, a 
      statistically significant association was observed for the unadjusted second 
      tercile of cadmium exposure (OR 1.87, 95% CI 1.06 to 3.30); however, this 
      association was no longer statistically significant after adjustment. None of the 
      other associations tested were statistically significant. Quantile g-computation 
      and BKMR both yielded no significant change of risk of DOR for the mixture of 
      metals, with no evidence of interaction. CONCLUSIONS: Weak signals that some 
      heavy metals could be associated with DOR were detected. These findings should be 
      replicated in other studies.
CI  - Copyright (c) 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Genard-Walton, Maximilien
AU  - Genard-Walton M
AD  - Universite de Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, 
      environnement et travail) - UMR_S 1085, F-35000 Rennes, France. Electronic 
      address: maximilien.genard-walton@inserm.fr.
FAU - Warembourg, Charline
AU  - Warembourg C
AD  - Universite de Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, 
      environnement et travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Duros, Solene
AU  - Duros S
AD  - Reproductive Medicine, CHU Rennes, 35200 Rennes, France.
FAU - Ropert-Bouchet, Martine
AU  - Ropert-Bouchet M
AD  - Laboratoire de Biochimie Toxicologie, CHU Rennes, Univ Rennes, 35033 Rennes, 
      France.
FAU - Lefebvre, Tiphaine
AU  - Lefebvre T
AD  - Reproductive Medicine, CHU Nantes, 44093 Nantes, France.
FAU - Guivarc'h-Leveque, Anne
AU  - Guivarc'h-Leveque A
AD  - Reproductive Medicine, Clinique de La Sagesse, 35043 Rennes, France.
FAU - Le Martelot, Marie-Therese
AU  - Le Martelot MT
AD  - Reproductive Medicine, CHU Brest, 29609 Brest, France.
FAU - Jacquemin, Benedicte
AU  - Jacquemin B
AD  - Universite de Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, 
      environnement et travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Cordier, Sylvaine
AU  - Cordier S
AD  - Universite de Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, 
      environnement et travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Costet, Nathalie
AU  - Costet N
AD  - Universite de Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, 
      environnement et travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Multigner, Luc
AU  - Multigner L
AD  - Universite de Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, 
      environnement et travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Garlantezec, Ronan
AU  - Garlantezec R
AD  - Universite de Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en 
      sante, environnement et travail) - UMR_S 1085, F-35000 Rennes, France.
LA  - eng
PT  - Journal Article
DEP - 20230602
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 00BH33GNGH (Cadmium)
RN  - 0 (Metals, Heavy)
RN  - 0R0008Q3JB (Chromium)
RN  - 80497-65-0 (Anti-Mullerian Hormone)
SB  - IM
MH  - Humans
MH  - Female
MH  - Adolescent
MH  - Young Adult
MH  - Adult
MH  - Infant, Newborn
MH  - Male
MH  - *Ovarian Reserve
MH  - Cadmium
MH  - Bayes Theorem
MH  - *Ovarian Diseases
MH  - *Metals, Heavy
MH  - Chromium
MH  - Anti-Mullerian Hormone
OTO - NOTNLM
OT  - chemical exposures
OT  - environmental epidemiology
OT  - female fertility
OT  - heavy metals
OT  - mixtures
OT  - reproductive outcomes
EDAT- 2023/07/15 10:42
MHDA- 2023/09/08 06:43
CRDT- 2023/07/14 22:00
PHST- 2023/01/09 00:00 [received]
PHST- 2023/04/25 00:00 [revised]
PHST- 2023/05/31 00:00 [accepted]
PHST- 2023/09/08 06:43 [medline]
PHST- 2023/07/15 10:42 [pubmed]
PHST- 2023/07/14 22:00 [entrez]
AID - S1472-6483(23)00340-1 [pii]
AID - 10.1016/j.rbmo.2023.05.013 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2023 Sep;47(3):103241. doi: 10.1016/j.rbmo.2023.05.013. 
      Epub 2023 Jun 2.