PMID- 37452704
OWN - NLM
STAT- MEDLINE
DCOM- 20230822
LR  - 20231106
IS  - 1535-3699 (Electronic)
IS  - 1535-3702 (Print)
IS  - 1535-3699 (Linking)
VI  - 248
IP  - 9
DP  - 2023 May
TI  - Influence of polymorphic variations of IFNL, HLA, and IL-6 genes in severe cases 
      of COVID-19.
PG  - 787-797
LID - 10.1177/15353702231181343 [doi]
AB  - The administration of vaccination doses to the global population has led to a 
      decrease in the incidence of COVID-19. However, the clinical picture developed by 
      infected individuals remains extremely concerning due to the great variability in 
      the severity of cases even in vaccinated individuals. The clinical progression of 
      the pathology is characterized by various influential factors such as sex, age 
      group, comorbidities, and the genetics of the individual. The immune response to 
      viral infections can be strongly influenced by the genetics of individuals; 
      nucleotide variations called single-nucleotide polymorphisms (SNPs) in structures 
      involved in the innate and adaptive immune response such as interferon (IFN)-lambda, 
      human leukocyte antigen (HLA), and interleukin (IL)-6 are frequently associated 
      with pathological progression. In this study, we conducted a review of the main 
      SNPs of these structures that are associated with severity in COVID-19. Searches 
      were conducted on some platforms of the National Center for Biotechnology and 
      Information (NCBI), and 102 studies were selected for full reading according to 
      the inclusion criteria. IFNs showed a strong association with antiviral function, 
      specifically, IFN-lambda3 (IL-28B) demonstrated genetic variants commonly related to 
      clinical progression in various pathologies. For COVID-19, rs12979860 and 
      rs1298275 presented frequently described unfavorable genotypes for pathological 
      conditions of hepatitis C and hepatocellular carcinoma. The high genetic 
      variability of HLA was reported in the studies as a crucial factor relevant to 
      the late immune response, mainly due to its ability to recognize antigens, with 
      the HLA-B*46:01 SNP being associated with susceptibility to COVID-19. For IL-6, 
      rs1554606 showed a strong relationship with the clinical progression of COVID-19. 
      In addition, rs2069837 was identified with possible host protection relationships 
      when linked to this infection.
FAU - Araujo, Adrhyan
AU  - Araujo A
AD  - Laboratorio de Virologia Molecular, Fundacao Oswaldo Cruz Rondonia (FIOCRUZ/RO), 
      Porto Velho 76812-329, Brazil.
AD  - Centro de Pesquisa em Medicina Tropical (CEPEM), Porto Velho 76812-329, Brazil.
FAU - Sgorlon, Gabriella
AU  - Sgorlon G
AUID- ORCID: 0000-0002-0221-2344
AD  - Laboratorio de Virologia Molecular, Fundacao Oswaldo Cruz Rondonia (FIOCRUZ/RO), 
      Porto Velho 76812-329, Brazil.
AD  - Centro de Pesquisa em Medicina Tropical (CEPEM), Porto Velho 76812-329, Brazil.
AD  - Programa de Pos-Graduacao em Biologia Experimental, Universidade Federal de 
      Rondonia (UNIR), Porto Velho 76801-059, Brazil.
FAU - Aguiar, Leticia Ereira
AU  - Aguiar LE
AD  - Faculdades Integradas Aparicio Carvalho (FIMCA), Porto Velho 76811-678, Brazil.
FAU - Cidrao, Matheus Henrique Monteiro Cavalcante
AU  - Cidrao MHMC
AD  - Faculdades Integradas Aparicio Carvalho (FIMCA), Porto Velho 76811-678, Brazil.
FAU - Teixeira, Karolaine Santos
AU  - Teixeira KS
AD  - Laboratorio de Virologia Molecular, Fundacao Oswaldo Cruz Rondonia (FIOCRUZ/RO), 
      Porto Velho 76812-329, Brazil.
AD  - Centro de Pesquisa em Medicina Tropical (CEPEM), Porto Velho 76812-329, Brazil.
FAU - Villalobos Salcedo, Juan Miguel
AU  - Villalobos Salcedo JM
AD  - Laboratorio de Virologia Molecular, Fundacao Oswaldo Cruz Rondonia (FIOCRUZ/RO), 
      Porto Velho 76812-329, Brazil.
AD  - Universidade Federal de Rondonia (UNIR), Porto Velho 76801-059, Brazil.
FAU - Passos-Silva, Ana Maisa
AU  - Passos-Silva AM
AD  - Laboratorio de Virologia Molecular, Fundacao Oswaldo Cruz Rondonia (FIOCRUZ/RO), 
      Porto Velho 76812-329, Brazil.
AD  - Centro de Pesquisa em Medicina Tropical (CEPEM), Porto Velho 76812-329, Brazil.
AD  - Programa de Pos-Graduacao em Biologia Experimental, Universidade Federal de 
      Rondonia (UNIR), Porto Velho 76801-059, Brazil.
FAU - Vieira, Deusilene
AU  - Vieira D
AD  - Laboratorio de Virologia Molecular, Fundacao Oswaldo Cruz Rondonia (FIOCRUZ/RO), 
      Porto Velho 76812-329, Brazil.
AD  - Centro de Pesquisa em Medicina Tropical (CEPEM), Porto Velho 76812-329, Brazil.
AD  - Programa de Pos-Graduacao em Biologia Experimental, Universidade Federal de 
      Rondonia (UNIR), Porto Velho 76801-059, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230715
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 0 (HLA Antigens)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukins)
RN  - 0 (IL6 protein, human)
SB  - IM
MH  - Humans
MH  - *COVID-19/genetics
MH  - Disease Progression
MH  - Genotype
MH  - HLA Antigens/genetics
MH  - Interleukin-6/genetics
MH  - Interleukins/genetics
MH  - *Liver Neoplasms
MH  - Polymorphism, Single Nucleotide/genetics
PMC - PMC10350587
OTO - NOTNLM
OT  - COVID-19
OT  - HLA
OT  - IFN-lambda
OT  - IL-6
OT  - Immunogenetic
OT  - polymorphism
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2023/07/15 21:05
MHDA- 2023/08/21 06:42
PMCR- 2024/01/15
CRDT- 2023/07/15 07:33
PHST- 2023/08/21 06:42 [medline]
PHST- 2023/07/15 21:05 [pubmed]
PHST- 2023/07/15 07:33 [entrez]
PHST- 2024/01/15 00:00 [pmc-release]
AID - 10.1177_15353702231181343 [pii]
AID - 10.1177/15353702231181343 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2023 May;248(9):787-797. doi: 10.1177/15353702231181343. 
      Epub 2023 Jul 15.