PMID- 37453195
OWN - NLM
STAT- MEDLINE
DCOM- 20230817
LR  - 20230817
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 165
DP  - 2023 Sep
TI  - Harnessing exosomes as cutting-edge drug delivery systems for revolutionary 
      osteoarthritis therapy.
PG  - 115135
LID - S0753-3322(23)00926-5 [pii]
LID - 10.1016/j.biopha.2023.115135 [doi]
AB  - Exosomes, remarkable extracellular vesicles, have emerged as an advanced frontier 
      in intercellular communication. This remarkable capacity positions them as 
      promising contenders in drug delivery systems (DDSs) for osteoarthritis (OA) 
      therapy, capitalizing on their inherent biocompatibility, stability, and minimal 
      immunogenicity. In this comprehensive review, we summarize the emerging 
      developments surrounding exosome-based DDSs for OA therapy. Focusing on exosome 
      origins, we meticulously explore the diverse sources contributing to their 
      production, including invaluable stem cells, immune cells, and an array of other 
      cell types. In addition, we unravel the underlying mechanisms of action that 
      govern these exosome-borne therapeutics, illuminating the intricate interplay 
      between exosomes and recipient cells. In summary, this review highlights the 
      present challenges that permeate exosome-based DDSs for OA therapy. Through an 
      in-depth exploration of the intricacies within this emerging field, this review 
      aims to shed light on the future direction of exosome-based DDSs in OA. It serves 
      as a bridge for fostering collaboration and collective efforts in reshaping the 
      treatment landscape of OA.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Lu, Jun
AU  - Lu J
AD  - Department of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong 
      University, Xi'an City, Shaanxi Province 710054, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong 
      University, Xi'an City, Shaanxi Province 710054, China.
FAU - Yang, Xinquan
AU  - Yang X
AD  - Department of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong 
      University, Xi'an City, Shaanxi Province 710054, China.
FAU - Zhao, Hongmou
AU  - Zhao H
AD  - Department of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong 
      University, Xi'an City, Shaanxi Province 710054, China. Electronic address: 
      zhaohongmou@xiyi.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230713
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
SB  - IM
MH  - Humans
MH  - *Exosomes/metabolism
MH  - Drug Delivery Systems
MH  - *Osteoarthritis/drug therapy/metabolism
MH  - Cell Communication
MH  - Stem Cells
OTO - NOTNLM
OT  - Drug delivery
OT  - Exosome
OT  - Nanomedicine
OT  - Osteoarthritis
OT  - Pharmacotherapy
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/07/16 01:07
MHDA- 2023/08/17 06:43
CRDT- 2023/07/15 18:01
PHST- 2023/06/07 00:00 [received]
PHST- 2023/06/30 00:00 [revised]
PHST- 2023/07/07 00:00 [accepted]
PHST- 2023/08/17 06:43 [medline]
PHST- 2023/07/16 01:07 [pubmed]
PHST- 2023/07/15 18:01 [entrez]
AID - S0753-3322(23)00926-5 [pii]
AID - 10.1016/j.biopha.2023.115135 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2023 Sep;165:115135. doi: 10.1016/j.biopha.2023.115135. Epub 
      2023 Jul 13.