PMID- 37454019
OWN - NLM
STAT- MEDLINE
DCOM- 20230920
LR  - 20230923
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 30
IP  - 11
DP  - 2023 Oct
TI  - Prognosis of Concurrent Versus Sequential Chemo-Radiotherapy Induction Followed 
      by Surgical Resection in Patients with Advanced Thymic Epithelial Tumors: A 
      Retrospective Study.
PG  - 6739-6747
LID - 10.1245/s10434-023-13954-x [doi]
AB  - BACKGROUND: This study aimed to evaluate the prognosis of concurrent 
      chemo-radiotherapy (CCRT) versus sequential chemo-radiotherapy (SCRT) induction 
      followed by surgical resection in patients with advanced thymic epithelial tumors 
      (TETs). METHODS: This retrospective study included patients with advanced TETs 
      who underwent CCRT or SCRT induction followed by surgical resection at the Second 
      General Hospital of Guangdong Province between January 2008 and December 2019. 
      The primary outcomes were induction response rate and surgical complete resection 
      rate. The secondary outcomes were surgery combined resection, post-induction T 
      staging, postoperative TNM staging, postoperative pathological tumor regression 
      grade, progression-free survival (PFS) and overall survival (OS), and adverse 
      events (AEs). RESULTS: A total of 31 patients were included, 15 of whom received 
      CCRT and the other 16 SCRT. The induction response rates were 80.0 and 62.5%, 
      respectively, the post-induction step-down rates were 46.7 and 31.3%, 
      respectively, and the post-induction R0 resection rates were 80.0 and 68.8%, 
      respectively, without significant differences between CCRT and SCRT groups (all P 
      > 0.05). The 5-year OS rate was 64.2 and 51.6%, respectively, and PFS was 42.3 
      and 21.4%, respectively, without significant differences between CCRT and SCRT 
      groups (both P > 0.05). AEs in the hematologic system were significantly higher 
      with CCRT compared with SCRT (P = 0.009). CONCLUSIONS: Patients with advanced 
      TETs might have a good prognosis with both CCRT and SCRT induction therapy, while 
      SCRT induction may result in a lower probability of AEs in the hematologic 
      system.
CI  - (c) 2023. Society of Surgical Oncology.
FAU - Guan, Shubin
AU  - Guan S
AD  - Department of Chest Wall Surgery, Guangdong Second Provincial General Hospital, 
      Guangzhou, China. guanshubin0310@foxmail.com.
FAU - Long, Weiguang
AU  - Long W
AD  - Department of Chest Wall Surgery, Guangdong Second Provincial General Hospital, 
      Guangzhou, China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Department of Chest Wall Surgery, Guangdong Second Provincial General Hospital, 
      Guangzhou, China.
FAU - Cai, Bin
AU  - Cai B
AD  - Department of Chest Wall Surgery, Guangdong Second Provincial General Hospital, 
      Guangzhou, China.
FAU - Luo, Juan
AU  - Luo J
AD  - Department of Chest Wall Surgery, Guangdong Second Provincial General Hospital, 
      Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20230715
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
SB  - IM
MH  - Humans
MH  - Retrospective Studies
MH  - *Chemoradiotherapy
MH  - Prognosis
MH  - Neoplasm Staging
OTO - NOTNLM
OT  - Advanced thymic epithelial tumors
OT  - Chemo-radiotherapy
OT  - Concurrent
OT  - Induction response rate
OT  - Retrospective study
OT  - Sequential
OT  - Surgical complete resection rate
EDAT- 2023/07/16 01:06
MHDA- 2023/09/20 06:42
CRDT- 2023/07/15 23:06
PHST- 2022/10/04 00:00 [received]
PHST- 2023/06/19 00:00 [accepted]
PHST- 2023/09/20 06:42 [medline]
PHST- 2023/07/16 01:06 [pubmed]
PHST- 2023/07/15 23:06 [entrez]
AID - 10.1245/s10434-023-13954-x [pii]
AID - 10.1245/s10434-023-13954-x [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2023 Oct;30(11):6739-6747. doi: 10.1245/s10434-023-13954-x. Epub 
      2023 Jul 15.