PMID- 37454409
OWN - NLM
STAT- MEDLINE
DCOM- 20230814
LR  - 20231015
IS  - 1872-7484 (Electronic)
IS  - 1566-0702 (Linking)
VI  - 248
DP  - 2023 Sep
TI  - Sympathetic and angiotensinergic activity in spontaneously hypertensive rats 
      treated with 3-amino-1,2,4-triazole.
PG  - 103107
LID - S1566-0702(23)00036-X [pii]
LID - 10.1016/j.autneu.2023.103107 [doi]
AB  - Previous studies from our laboratory have shown that the pressor response to 
      intracerebroventricular (icv) administered ANG II in normotensive rats or 
      spontaneously hypertensive rats (SHRs) is attenuated by increased central 
      H(2)O(2) concentration, produced either by direct H(2)O(2) icv injection or by 
      increased endogenous H(2)O(2) centrally in response to local catalase inhibition 
      with 3-amino-1,2,4-triazole (ATZ). In the present study, we evaluated the effects 
      of ATZ administered peripherally on arterial pressure and sympathetic and 
      angiotensinergic activity in SHRs. Male SHRs weighing 280-330 g were used. Mean 
      arterial pressure (MAP) and heart rate (HR) were recorded in conscious freely 
      moving SHRs. Acute intravenous injection of ATZ (300 mg/kg of body weight) did 
      not modify MAP and HR during the next 4 h, however, the treatment with ATZ 
      (300 mg/kg of body weight twice per day) for 3 days reduced MAP (144 +/- 6, vs. 
      saline, 183 +/- 13 mmHg), without changing HR. Intravenous hexamethonium 
      (ganglionic blocker) produced a smaller decrease in MAP 4 h after ATZ (-25 +/- 3, 
      vs saline -38 +/- 4 mmHg). Losartan (angiotensinergic AT(1) receptor blocker) 
      produced a significant depressor response 4 h after ATZ (-22 +/- 4, vs. saline: 
      -2 +/- 4 mmHg) and in 3-day ATZ treated SHRs (-25 +/- 5, vs. saline: -9 +/- 4 mmHg). 
      The results suggest that the treatment with ATZ reduces sympathetic activity in 
      SHRs and simultaneously increases angiotensinergic activity.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Pontes, Roberto Braz
AU  - Pontes RB
AD  - Department of Physiology and Pathology, School of Dentistry, Sao Paulo State 
      University, UNESP, Araraquara, SP, Brazil.
FAU - Colombari, Debora S A
AU  - Colombari DSA
AD  - Department of Physiology and Pathology, School of Dentistry, Sao Paulo State 
      University, UNESP, Araraquara, SP, Brazil.
FAU - De Paula, Patricia M
AU  - De Paula PM
AD  - Department of Physiology and Pathology, School of Dentistry, Sao Paulo State 
      University, UNESP, Araraquara, SP, Brazil.
FAU - Colombari, Eduardo
AU  - Colombari E
AD  - Department of Physiology and Pathology, School of Dentistry, Sao Paulo State 
      University, UNESP, Araraquara, SP, Brazil.
FAU - Andrade, Carina A F
AU  - Andrade CAF
AD  - Department of Physiology and Pathology, School of Dentistry, Sao Paulo State 
      University, UNESP, Araraquara, SP, Brazil.
FAU - De Luca, Laurival A Jr
AU  - De Luca LA Jr
AD  - Department of Physiology and Pathology, School of Dentistry, Sao Paulo State 
      University, UNESP, Araraquara, SP, Brazil.
FAU - Menani, Jose V
AU  - Menani JV
AD  - Department of Physiology and Pathology, School of Dentistry, Sao Paulo State 
      University, UNESP, Araraquara, SP, Brazil. Electronic address: 
      jv.menani@unesp.br.
LA  - eng
PT  - Journal Article
DEP - 20230709
PL  - Netherlands
TA  - Auton Neurosci
JT  - Autonomic neuroscience : basic & clinical
JID - 100909359
RN  - ZF80H5GXUF (Amitrole)
RN  - 0 (Triazoles)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - Rats, Inbred SHR
MH  - Amitrole/pharmacology
MH  - *Triazoles/pharmacology
MH  - Hydrogen Peroxide/pharmacology
MH  - Blood Pressure
MH  - Heart Rate
MH  - Body Weight
MH  - *Hypertension/drug therapy
OTO - NOTNLM
OT  - Arterial pressure
OT  - Catalase
OT  - H(2)O(2)
OT  - Hypertension
EDAT- 2023/07/16 19:16
MHDA- 2023/08/14 06:42
CRDT- 2023/07/16 18:00
PHST- 2023/04/12 00:00 [received]
PHST- 2023/06/28 00:00 [revised]
PHST- 2023/07/07 00:00 [accepted]
PHST- 2023/08/14 06:42 [medline]
PHST- 2023/07/16 19:16 [pubmed]
PHST- 2023/07/16 18:00 [entrez]
AID - S1566-0702(23)00036-X [pii]
AID - 10.1016/j.autneu.2023.103107 [doi]
PST - ppublish
SO  - Auton Neurosci. 2023 Sep;248:103107. doi: 10.1016/j.autneu.2023.103107. Epub 2023 
      Jul 9.