PMID- 37455824
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230718
IS  - 2692-3114 (Electronic)
IS  - 2692-3114 (Linking)
VI  - 4
IP  - 3
DP  - 2023
TI  - Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft.
PG  - 511-518
LID - 10.37349/etat.2023.00148 [doi]
AB  - Transmission of a malignancy from a donor's organ to the recipient of the graft 
      is a rare event, though it is a severe complication that can result in a poor 
      outcome. Usually, immunosuppressive therapy is discontinued and the allograft is 
      removed. However, treatment of patients with the disseminated cancers implies 
      that after the graft removal and cessation of the immunosuppression, 
      radiotherapy, chemotherapy, or immunotherapy with alpha-interferon (INF-alpha) or 
      interleukin-2 (IL-2) are required. The case report presents a clinical case of a 
      transmitted kidney graft with multiple metastases (MTS) in a 31-year-old woman 
      with the spontaneous regression of the metastatic cancer after transplantectomy 
      and cancellation of the immunosuppressive therapy. Obviously, the determining 
      factor is the recognition of the tumor by the effectors of the antitumor immunity 
      due to the human leukocyte antigen (HLA) mismatch between the donor and the 
      recipient. Therefore, cancellation of the immunosuppressive therapy in cases of 
      transferal of a malignancy with a transplanted organ allows the effectors of the 
      immune system to distinguish the tumor as a foreign tissue and effectively 
      eliminate this neoplasm.
CI  - (c) The Author(s) 2023.
FAU - Kiselevskiy, Mikhail V
AU  - Kiselevskiy MV
AUID- ORCID: 0000-0002-0132-167X
AD  - Laboratory of Cell Immunity, N.N. Blokhin National Medical Research Center of 
      Oncology, Ministry of Health of Russia, Moscow 115552, Russia.
FAU - Gromova, Elena G
AU  - Gromova EG
AUID- ORCID: 0000-0002-4633-8301
AD  - Intensive Care Unit, N.N. Blokhin National Medical Research Center of Oncology, 
      Ministry of Health of Russia, Moscow 115552, Russia.
FAU - Kozlov, Nikolay A
AU  - Kozlov NA
AUID- ORCID: 0000-0003-3852-3969
AD  - Pathology Department, Division of Morphological and Molecular Genetic Diagnostics 
      of Tumors, N.N. Blokhin National Medical Research Center of Oncology, Ministry of 
      Health of Russia, Moscow 115552, Russia.
FAU - Bezhanova, Svetlana D
AU  - Bezhanova SD
AUID- ORCID: 0000-0001-7336-9210
AD  - Pathology Department, Division of Morphological and Molecular Genetic Diagnostics 
      of Tumors, N.N. Blokhin National Medical Research Center of Oncology, Ministry of 
      Health of Russia, Moscow 115552, Russia.
FAU - Shubina, Irina Zh
AU  - Shubina IZ
AUID- ORCID: 0000-0002-9374-3158
AD  - Laboratory of Cell Immunity, N.N. Blokhin National Medical Research Center of 
      Oncology, Ministry of Health of Russia, Moscow 115552, Russia.
LA  - eng
PT  - Case Reports
DEP - 20230630
PL  - United States
TA  - Explor Target Antitumor Ther
JT  - Exploration of targeted anti-tumor therapy
JID - 101770662
PMC - PMC10344895
OTO - NOTNLM
OT  - Cancer
OT  - immunosuppressive therapy
OT  - kidney graft
OT  - spontaneous regressions
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2023/07/17 06:42
MHDA- 2023/07/17 06:43
PMCR- 2023/06/30
CRDT- 2023/07/17 04:16
PHST- 2022/12/20 00:00 [received]
PHST- 2023/03/09 00:00 [accepted]
PHST- 2023/07/17 06:43 [medline]
PHST- 2023/07/17 06:42 [pubmed]
PHST- 2023/07/17 04:16 [entrez]
PHST- 2023/06/30 00:00 [pmc-release]
AID - 10.37349/etat.2023.00148 [doi]
PST - ppublish
SO  - Explor Target Antitumor Ther. 2023;4(3):511-518. doi: 10.37349/etat.2023.00148. 
      Epub 2023 Jun 30.