PMID- 37456164 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230718 IS - 1792-1015 (Electronic) IS - 1792-0981 (Print) IS - 1792-0981 (Linking) VI - 26 IP - 2 DP - 2023 Aug TI - Association between anemia and the risk and outcomes of diabetic foot in patients with type 2 diabetes mellitus. PG - 384 LID - 10.3892/etm.2023.12083 [doi] LID - 384 AB - The aim of the present study was to explore the association between anemia and the risks and outcomes of diabetic foot (DF) in patients with type 2 diabetes mellitus (T2DM). A total of 145 patients with T2DM were recruited between January and December 2021 and divided into the DF and non-DF groups according to whether they were diagnosed with DF. Individual patient data were extracted and blood samples were evaluated in a biochemical center for routine biochemical and blood-related indicators. The patients' survival rates were followed up until December 2022. An independent-samples t-test and chi(2) test were used to compare the differences between the two groups. The association between the various clinical indicators for the DF and non-DF groups was evaluated using single-factor binary logistic regression analysis. Multi-factor binary logistic regression analysis was used to analyze the association between hemoglobin (Hb) and the risk for DF. A Kaplan-Meier survival curve was used to analyze the impact of anemia and DF on the 1-year survival rate. The diabetes duration, number of patients who smoked and consumed alcohol, and serum creatinine and C-reactive protein levels in the DF group were significantly higher than those in the non-DF group (P<0.05). By contrast, the estimated glomerular filtration rate (eGFR) and Hb, albumin (Alb) and total cholesterol levels, were lower in the DF group when compared with those in the non-DF group (P<0.05). All of the study participants were divided into two groups, according to their baseline eGFR [eGFR >/=90 or <90 ml/(min x 1.73 m(2))]. It was found that, independently of renal function, lower Hb and Alb levels were associated with a higher incidence of DF. The 1-year survival rate for DF with anemia was significantly lower when compared with that in patients with DF without anemia (P<0.05). In conclusion, the Hb level in patients with T2DM is a protective factor against DF and anemia is an independent risk factor for DF. The present study suggested that anemia is associated with a decrease in the survival rate of patients with DF. This finding provided a theoretical basis for the clinical correction of anemia and improvement of DF prognosis (clinical trial no. 20220003). CI - Copyright (c) 2020, Spandidos Publications. FAU - Li, Jing AU - Li J AD - Department of Endocrinology and Metabolism, Suqian First Hospital, Suqian, Jiangsu 223800, P.R. China. FAU - Zhang, Zhou AU - Zhang Z AD - Translational Medical Research Centre, Wuxi No. 2 People's Hospital, Affiliated Wuxi Clinical College of Nantong University, Jiangnan University Medical Center, Wuxi, Jiangsu 214002, P.R. China. FAU - Wei, Jilin AU - Wei J AD - Department of Endocrinology and Metabolism, Suqian First Hospital, Suqian, Jiangsu 223800, P.R. China. FAU - Li, Ying AU - Li Y AD - Department of Endocrinology and Metabolism, Suqian First Hospital, Suqian, Jiangsu 223800, P.R. China. FAU - Cheng, Cheng AU - Cheng C AD - Department of Endocrinology and Metabolism, Suqian First Hospital, Suqian, Jiangsu 223800, P.R. China. FAU - Ma, Shaogang AU - Ma S AD - Department of Endocrinology and Metabolism, The People's Hospital of Laibin, Laibin, Guangxi Zhuang Autonomous Region 546100, P.R. China. FAU - Guo, Manli AU - Guo M AD - Department of Endocrinology and Metabolism, The Affiliated Suqian Hospital of XuZhou Medical University and Nanjing Drum Tower Hospital Group Suqian Hospital, Suqian, Jiangsu 223800, P.R. China. LA - eng PT - Journal Article DEP - 20230628 PL - Greece TA - Exp Ther Med JT - Experimental and therapeutic medicine JID - 101531947 PMC - PMC10347232 OTO - NOTNLM OT - anemia OT - diabetic foot OT - risk factors OT - survival rate OT - type 2 diabetes mellitus COIS- The authors declare that they have no competing interests. EDAT- 2023/07/17 06:42 MHDA- 2023/07/17 06:43 PMCR- 2023/06/28 CRDT- 2023/07/17 04:21 PHST- 2023/03/16 00:00 [received] PHST- 2023/05/12 00:00 [accepted] PHST- 2023/07/17 06:43 [medline] PHST- 2023/07/17 06:42 [pubmed] PHST- 2023/07/17 04:21 [entrez] PHST- 2023/06/28 00:00 [pmc-release] AID - ETM-26-2-12083 [pii] AID - 10.3892/etm.2023.12083 [doi] PST - epublish SO - Exp Ther Med. 2023 Jun 28;26(2):384. doi: 10.3892/etm.2023.12083. eCollection 2023 Aug.