PMID- 37457684
OWN - NLM
STAT- MEDLINE
DCOM- 20230718
LR  - 20230719
IS  - 2048-6790 (Electronic)
IS  - 2048-6790 (Linking)
VI  - 12
DP  - 2023
TI  - Hypolipidaemic effects of papaya (Carica papaya L.) juice on rats fed on a high 
      fat and fructose diet.
PG  - e76
LID - 10.1017/jns.2023.61 [doi]
LID - e76
AB  - Papaya (Carica papaya L.) is a highly nutritious and less-caloric fruit, commonly 
      consumed for its minerals and vitamins and hence may help in controlling obesity 
      and abdominal discomforts. The present study investigated the hypolipidaemic 
      effects of papaya juice extract on male Albino Wistar rats (7 weeks old; 185 +/- 17 
      g) fed on a high fat and fructose diet (HFFD) for 6 weeks. The rats were divided 
      into groups I-IV of five rats each and fed on either a HFFD (i.e. the Control), 
      HFFD + 200 mg papaya, HFFD + 350 mg papaya or a HFFD + 500 mg papaya. On day 34, 
      after an overnight fast, blood samples were obtained by cardiac puncture under 
      99⋅8 % Chloroform anaesthesia for the determination of serum triglyceride (TG), 
      total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and 
      high-density cholesterol (HDL-c). The atherogenic (AI) and coronary risk (CRI) 
      indices were also calculated. Statistical analysis was performed using ANOVA 
      where means were separated using Tukey's HSD test. Resulted showed that all rats 
      given papaya juice had an increasing, non-significant HDL-c and reduced LDL-c 
      levels while rats fed on HFFD had the highest TC (53⋅2 mg/dl) and TG (37⋅6 mg/dl) 
      levels. Papaya juice statistically reduced the AI and CRI of the rats. In 
      conclusion, consumption of HFFD + 500 mg was the most effective in the reduction 
      of rats' blood lipids and fats, due to its anti-obesity and hypolipidaemic 
      properties, thus can be used in the management of dyspilidaemic disorders.
CI  - (c) The Author(s) 2023.
FAU - Matsuane, Christinah
AU  - Matsuane C
AD  - Department of Horticulture and Food Security, Jomo Kenyatta University of 
      Agriculture and Technology, P.O. Box, Nairobi 62000-00200, Kenya.
AD  - Department of Crop and Soil Sciences, Botswana University of Agriculture and 
      Natural Resources, Private Bag 0027, Gaborone, Botswana.
FAU - Kiage, Beatrice N
AU  - Kiage BN
AD  - Department of Human Nutrition, Jomo Kenyatta University of Agriculture and 
      Technology, P.O. Box, Nairobi 62000-00200, Kenya.
FAU - Karanja, Josephine
AU  - Karanja J
AD  - Department of Horticulture and Food Security, Jomo Kenyatta University of 
      Agriculture and Technology, P.O. Box, Nairobi 62000-00200, Kenya.
FAU - Kavoo, Agnes M
AU  - Kavoo AM
AD  - Department of Horticulture and Food Security, Jomo Kenyatta University of 
      Agriculture and Technology, P.O. Box, Nairobi 62000-00200, Kenya.
FAU - Rimberia, Fredah K
AU  - Rimberia FK
AD  - Department of Horticulture and Food Security, Jomo Kenyatta University of 
      Agriculture and Technology, P.O. Box, Nairobi 62000-00200, Kenya.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230710
PL  - England
TA  - J Nutr Sci
JT  - Journal of nutritional science
JID - 101590587
RN  - 0 (Cholesterol, LDL)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - *Carica
MH  - Cholesterol, LDL
MH  - Fructose
MH  - Diet, High-Fat/adverse effects
MH  - Rats, Wistar
MH  - *Hyperlipidemias/drug therapy
MH  - Obesity/drug therapy
MH  - *Hypercholesterolemia
MH  - Vegetables
PMC - PMC10345780
OTO - NOTNLM
OT  - Blood lipids
OT  - High fat and fructose diet
OT  - Hypolipidaemic
OT  - Papaya (Carica papaya L.)
EDAT- 2023/07/17 06:42
MHDA- 2023/07/18 13:08
PMCR- 2023/01/01
CRDT- 2023/07/17 04:42
PHST- 2023/02/06 00:00 [received]
PHST- 2023/06/16 00:00 [revised]
PHST- 2023/06/16 00:00 [accepted]
PHST- 2023/07/18 13:08 [medline]
PHST- 2023/07/17 06:42 [pubmed]
PHST- 2023/07/17 04:42 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - S2048679023000617 [pii]
AID - 10.1017/jns.2023.61 [doi]
PST - epublish
SO  - J Nutr Sci. 2023 Jul 10;12:e76. doi: 10.1017/jns.2023.61. eCollection 2023.