PMID- 37457686
OWN - NLM
STAT- MEDLINE
DCOM- 20230718
LR  - 20230718
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - Exploration of the association between the single-nucleotide polymorphism of 
      co-stimulatory system and rheumatoid arthritis.
PG  - 1123832
LID - 10.3389/fimmu.2023.1123832 [doi]
LID - 1123832
AB  - INTRODUCTION: The human leukocyte antigen (HLA) has been linked to the majority 
      of autoimmune diseases (ADs). However, non-HLA genes may be risk factors for ADs. 
      A number of genes encoding proteins involved in regulating T-cell and B-cell 
      function have been identified as rheumatoid arthritis (RA) susceptibility genes. 
      METHODS: In this study, we investigated the association between RA and 
      single-nucleotide polymorphisms (SNPs) of co-stimulatory or co-inhibitory 
      molecules in 124 RA cases and 100 healthy controls without immune-related 
      diseases [including tumor necrosis factor superfamily member 4 (TNFSF4), CD28, 
      cytotoxic T-lymphocyte-associated protein 4 (CTLA4), and programmed cell death 
      protein 1 (PDCD1)]. RESULTS: The results showed that there were 13 SNPs 
      associated with RA, including rs181758110 of TNFSF4 (CC vs. CT, p = 0.038); 
      rs3181096 of CD28 (TT vs. CC + CT, p = 0.035; CC vs. TT, p = 0.047); rs11571315 
      (TT vs. CT, p = 0.045), rs733618 (CC vs. TT + CT, p = 0.043), rs4553808 (AA vs. 
      AG vs. GG, p = 0.035), rs11571316 (GG vs. AG vs. AA, p = 0.048; GG vs. AG + AA, p 
      = 0.026; GG vs. AG, p = 0.014), rs16840252 (CC vs. CT vs. TT, p = 0.007; CC vs. 
      CT, p = 0.011), rs5742909 (CC vs. CT vs. TT, p = 0.040), and rs11571319 of CTLA4 
      (GG vs. AG vs. AA, p < 0.001; GG vs. AG + AA, p = 0.048; AA vs. GG + AG, p = 
      0.001; GG vs. AA, p = 0.008; GG vs. AG, p </= 0.001); and rs10204525 (TT vs. CT + 
      CC, p = 0.024; TT vs. CT, p = 0.021), rs2227982 (AA vs. GG, p = 0.047), 
      rs36084323 (TT vs. CT vs. CC, p = 0.022; TT vs. CT + CC, p = 0.013; CC vs. TT + 
      CT, p = 0.048; TT vs. CC, p = 0.008), and rs5839828 of PDCD1 (DEL vs. DEL/G vs. 
      GG, p = 0.014; DEL vs. DEL/G + GG, p = 0.014; GG vs. DEL + DEL/G, p = 0.025; DEL 
      vs. GG, p = 0.007). DISCUSSION: Consequently, these SNPs may play an important 
      role in immune regulation, and further research into the role of these SNPs of 
      immune regulatory genes in the pathogenesis of RA is required.
CI  - Copyright (c) 2023 Chen, Wen, Lin, Hsu and Yu.
FAU - Chen, Ding-Ping
AU  - Chen DP
AD  - Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, 
      Taiwan.
AD  - Department of Medical Biotechnology and Laboratory Science, College of Medicine, 
      Chang Gung University, Taoyuan, Taiwan.
FAU - Wen, Ying-Hao
AU  - Wen YH
AD  - Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, 
      Taiwan.
AD  - School of Medicine, National Tsing Hua University, Hsinchu, Taiwan.
AD  - School of Medicine, Chang Gung University, Taoyuan, Taiwan.
AD  - Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Lin, Wei-Tzu
AU  - Lin WT
AD  - Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, 
      Taiwan.
FAU - Hsu, Fang-Ping
AU  - Hsu FP
AD  - Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, 
      Taiwan.
FAU - Yu, Kuang-Hui
AU  - Yu KH
AD  - Division of Rheumatology, Allergy, and Immunology, Linkou Chang Gung University 
      and Memorial Hospital, Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230629
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CD28 Antigens)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (TNFSF4 protein, human)
RN  - 0 (OX40 Ligand)
SB  - IM
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Genetic Predisposition to Disease
MH  - CTLA-4 Antigen/genetics
MH  - CD28 Antigens/genetics
MH  - *Arthritis, Rheumatoid/genetics
MH  - Tumor Necrosis Factor-alpha/genetics
MH  - OX40 Ligand/genetics
PMC - PMC10344454
OTO - NOTNLM
OT  - association
OT  - autoimmune disease (AD)
OT  - co-stimulatory system
OT  - rheumatoid arthritis (RA)
OT  - single nucleotide polymorphism (SNP)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/07/17 06:42
MHDA- 2023/07/18 13:09
PMCR- 2023/01/01
CRDT- 2023/07/17 04:43
PHST- 2022/12/14 00:00 [received]
PHST- 2023/06/01 00:00 [accepted]
PHST- 2023/07/18 13:09 [medline]
PHST- 2023/07/17 06:42 [pubmed]
PHST- 2023/07/17 04:43 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1123832 [doi]
PST - epublish
SO  - Front Immunol. 2023 Jun 29;14:1123832. doi: 10.3389/fimmu.2023.1123832. 
      eCollection 2023.