PMID- 37458409
OWN - NLM
STAT- MEDLINE
DCOM- 20230908
LR  - 20230909
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 11
IP  - 32
DP  - 2023 Sep 6
TI  - Quaternized carbon dots with enhanced antimicrobial ability towards Gram-negative 
      bacteria for the treatment of acute peritonitis caused by E. coli.
PG  - 7696-7706
LID - 10.1039/d3tb00889d [doi]
AB  - Infections caused by Gram-negative bacteria still pose a clinical challenge. 
      Although nanomaterials have been developed for antibacterial treatments, a 
      systematic evaluation of the mechanisms and intervention models of antibacterial 
      materials toward Gram-negative bacteria is still lacking. Herein, antibacterial 
      quaternized carbon dots (QCDs) were synthesized via a one-step melting method 
      using anhydrous citric acid and diallyl dimethyl ammonium chloride (DDA). The 
      QCDs exhibited effective broad-spectrum antibacterial activity and enhanced 
      inhibitory ability towards Gram-negative bacteria. The antibacterial mechanism of 
      the QCDs with respect to Gram-negative bacteria was investigated through the 
      characterization of bacterial morphology changes, the absorption modes of the 
      QCDs on bacteria, and the potential generation of reactive oxygen species by the 
      QCDs. The QCDs showed low toxicity in different cells, and did not cause 
      hemolysis. The QCDs were administered via intraperitoneal injection to treat 
      acute peritonitis in mice infected with E. coli. Routine blood examination, 
      magnetic resonance imaging, and pathological analysis were undertaken and it was 
      found that, similar to the positive control group treated with gentamicin 
      sulfate, the QCDs exhibited a therapeutic effect that eliminated infection and 
      inflammation. This study explores a controllable synthetic strategy for the 
      synthesis of active carbon dots with antibacterial activity, a material that is a 
      promising candidate for new treatments of Gram-negative bacterial infections.
FAU - Zhang, Xintian
AU  - Zhang X
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical 
      University, Fuzhou 350122, China. shweng@fjmu.edu.cn.
FAU - Wu, Pingping
AU  - Wu P
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical 
      University, Fuzhou 350122, China. shweng@fjmu.edu.cn.
FAU - Hao, Xiaoli
AU  - Hao X
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical 
      University, Fuzhou 350122, China. shweng@fjmu.edu.cn.
FAU - Liu, Jiamiao
AU  - Liu J
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical 
      University, Fuzhou 350122, China. shweng@fjmu.edu.cn.
FAU - Huang, Zhengjun
AU  - Huang Z
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical 
      University, Fuzhou 350122, China. shweng@fjmu.edu.cn.
FAU - Weng, Shaohuang
AU  - Weng S
AUID- ORCID: 0000-0002-4739-5615
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical 
      University, Fuzhou 350122, China. shweng@fjmu.edu.cn.
FAU - Chen, Weifeng
AU  - Chen W
AD  - Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, 350001, 
      China. hjy8191@163.com.
FAU - Huang, Lingling
AU  - Huang L
AD  - Department of Stomatology, The First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, 350005, China. huanglings@163.com.
FAU - Huang, Jianyong
AU  - Huang J
AD  - Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, 350001, 
      China. hjy8191@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230906
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 7440-44-0 (Carbon)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Escherichia coli
MH  - Carbon/pharmacology
MH  - *Anti-Infective Agents/pharmacology
MH  - Anti-Bacterial Agents/pharmacology/therapeutic use
MH  - Gram-Negative Bacteria
MH  - Bacteria
MH  - *Peritonitis/drug therapy
EDAT- 2023/07/17 15:09
MHDA- 2023/09/08 06:43
CRDT- 2023/07/17 08:43
PHST- 2023/09/08 06:43 [medline]
PHST- 2023/07/17 15:09 [pubmed]
PHST- 2023/07/17 08:43 [entrez]
AID - 10.1039/d3tb00889d [doi]
PST - epublish
SO  - J Mater Chem B. 2023 Sep 6;11(32):7696-7706. doi: 10.1039/d3tb00889d.