PMID- 37459907
OWN - NLM
STAT- MEDLINE
DCOM- 20231113
LR  - 20231114
IS  - 1098-8823 (Print)
IS  - 1098-8823 (Linking)
VI  - 169
DP  - 2023 Dec
TI  - The analysis of fatty acids and their derivatives in the liver of C57BL/6 mice 
      with long-term caloric restrictions.
PG  - 106764
LID - S1098-8823(23)00061-8 [pii]
LID - 10.1016/j.prostaglandins.2023.106764 [doi]
AB  - Caloric restriction (CR) is a dietetic intervention based on the reduction of 
      daily calorie intake by 10-30 %. When subjected to CR, the organism adjusts its 
      metabolism to the changing availability of key nutrients. However, fatty acids' 
      content in organisms subjected to long-term CR has not been evaluated. The aim of 
      the research was to analyze the influence of long-term CR on the contents of 
      medium- and long-chain fatty acids, as well as on the contents of fatty acid 
      derivatives in liver. The study was performed on C57BL female (n = 12) and male 
      (n = 12) mice subjected to lifelong 30 % calorie restriction. Fatty acids were 
      analyzed using gas chromatography, while fatty acid derivatives were analyzed 
      with liquid chromatography. The dynamics of change of the lipid profile of the 
      labeled fatty acids observed in the liver tissue confirms that lipolysis actively 
      takes place in this organ when hungry. Moreover, it is highly possible that de 
      novo synthesis of acids takes place, with the aim to ensure energy substrates to 
      the body. Moreover, an increase of concentration was observed for fatty acid 
      derivatives, those with anti-inflammatory properties (resolvin, LTX A4). However, 
      there was no increase in the concentration of pro-inflammatory eicosanoids. The 
      results suggest that it is important to take into consideration the introduction 
      of appropriate supplements when using CR.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Palma, J
AU  - Palma J
AD  - Department of Biochemical Science, Pomeranian Medical University in Szczecin, 
      Broniewskiego 24, 71-460 Szczecin, Poland.
FAU - Maciejewska-Markiewicz, D
AU  - Maciejewska-Markiewicz D
AD  - Department of Human Nutrition and Metabolomics, Pomeranian Medical University in 
      Szczecin, Broniewskiego 24, 71-460 Szczecin, Poland.
FAU - Zgutka, K
AU  - Zgutka K
AD  - Department of Physiology in Health Sciences, Pomeranian Medical University in 
      Szczecin, Zolnierska 54, 71-210 Szczecin, Poland.
FAU - D Piotrowska, K
AU  - D Piotrowska K
AD  - Department of Physiology, Pomeranian Medical University in Szczecin, Powstancow 
      Wlkp. 72, 70-111 Szczecin, Poland.
FAU - Skonieczna-Zydecka, K
AU  - Skonieczna-Zydecka K
AD  - Department of Biochemical Science, Pomeranian Medical University in Szczecin, 
      Broniewskiego 24, 71-460 Szczecin, Poland.
FAU - Stachowska, E
AU  - Stachowska E
AD  - Department of Human Nutrition and Metabolomics, Pomeranian Medical University in 
      Szczecin, Broniewskiego 24, 71-460 Szczecin, Poland. Electronic address: 
      ewa.stachowska@pum.edu.pl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230717
PL  - United States
TA  - Prostaglandins Other Lipid Mediat
JT  - Prostaglandins & other lipid mediators
JID - 9808648
RN  - 0 (Fatty Acids)
SB  - IM
MH  - Male
MH  - Female
MH  - Mice
MH  - Animals
MH  - *Fatty Acids/metabolism
MH  - *Caloric Restriction
MH  - Mice, Inbred C57BL
MH  - Liver/metabolism
OTO - NOTNLM
OT  - C57BL/6 mouse
OT  - Caloric restriction
OT  - Fatty acids
OT  - Fatty acids derivatives
OT  - Liver
COIS- Conflicts of interests The authors declare no conflict of interest.
EDAT- 2023/07/18 01:09
MHDA- 2023/11/13 06:42
CRDT- 2023/07/17 19:19
PHST- 2023/03/02 00:00 [received]
PHST- 2023/07/03 00:00 [revised]
PHST- 2023/07/08 00:00 [accepted]
PHST- 2023/11/13 06:42 [medline]
PHST- 2023/07/18 01:09 [pubmed]
PHST- 2023/07/17 19:19 [entrez]
AID - S1098-8823(23)00061-8 [pii]
AID - 10.1016/j.prostaglandins.2023.106764 [doi]
PST - ppublish
SO  - Prostaglandins Other Lipid Mediat. 2023 Dec;169:106764. doi: 
      10.1016/j.prostaglandins.2023.106764. Epub 2023 Jul 17.