PMID- 37460764
OWN - NLM
STAT- MEDLINE
DCOM- 20231007
LR  - 20231007
IS  - 1720-8319 (Electronic)
IS  - 1594-0667 (Linking)
VI  - 35
IP  - 10
DP  - 2023 Oct
TI  - Intrinsic capacity and 5-year late-life functional ability trajectories of 
      Chinese older population using ICOPE tool: the Rugao Longevity and Ageing Study.
PG  - 2061-2068
LID - 10.1007/s40520-023-02489-6 [doi]
AB  - BACKGROUND AND AIMS: Knowledge of how intrinsic capacity (IC) shape functional 
      ability (FA) trajectories in later life remains unclear. We investigated the 
      changes in IC and their impact on 5-years FA trajectories in the Chinese older 
      population. METHODS: A total of 1640 older adults from the Rugao Longitudinal 
      Ageing Study were included and analyzed. FA was assessed by The Lawton 
      Instrumental Activities of Daily Living Scale (IADLs). We used cognition, 
      psychology, locomotion, sensory capacity, and vitality to capture the multiple 
      domains of IC according to the ICOPE method. The IC was derived retrospectively 
      from variables collected before this was described by WHO. RESULTS: At baseline, 
      a higher IC was associated with higher IADLs (beta = 0.98, 95% CI 0.90, 1.06, 
      P < 0.001). Individuals with declines in IC between wave1 and wave2 experienced a 
      faster decline in IADLs over time (beta = - 0.28, 95% CI - 0.40, - 0.16, P < 0.001) 
      after considering covariates. One or more impairment IC scores at baseline 
      strongly predicted death (HR = 1.20, 95% CI 1.11, 1.30, P < 0.001). In addition, 
      according to the IC scores at baseline, we stratify IC in low, middle, and high, 
      compared with those in the high IC score, those in the low were associated with a 
      2.56-fold (95% CI 1.64, 4.01, P < 0.001) higher risk of mortality, after 
      adjustment for variables. CONCLUSION: Changes in IC shape FA trajectories. IC 
      impairment is associated with an increased risk of death. Assessing intrinsic 
      capacity would facilitate early identification of older adults at high risk of 
      adverse outcomes and prompt targeted interventions.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
FAU - Zhang, Na
AU  - Zhang N
AD  - MOE Key Laboratory of Contemporary Anthropology and School of Life Science and 
      Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
FAU - Zhang, Hui
AU  - Zhang H
AD  - Zhangjiang Fudan International Innovation Centre, Human Phenome Institute, Fudan 
      University, Shanghai, China.
FAU - Sun, Meng-Zhen
AU  - Sun MZ
AD  - Zhangjiang Fudan International Innovation Centre, Human Phenome Institute, Fudan 
      University, Shanghai, China.
FAU - Zhu, Yin-Sheng
AU  - Zhu YS
AD  - Rugao People's Hospital, Rugao, Jiangsu, China.
FAU - Shi, Guo-Ping
AU  - Shi GP
AD  - Rugao People's Hospital, Rugao, Jiangsu, China.
FAU - Wang, Zheng-Dong
AU  - Wang ZD
AD  - Rugao People's Hospital, Rugao, Jiangsu, China.
FAU - Wang, Jiu-Cun
AU  - Wang JC
AD  - MOE Key Laboratory of Contemporary Anthropology and School of Life Science and 
      Institutes of Biomedical Sciences, Fudan University, Shanghai, China. 
      jcwang@fudan.edu.cn.
AD  - Zhangjiang Fudan International Innovation Centre, Human Phenome Institute, Fudan 
      University, Shanghai, China. jcwang@fudan.edu.cn.
FAU - Wang, Xiao-Feng
AU  - Wang XF
AD  - MOE Key Laboratory of Contemporary Anthropology and School of Life Science and 
      Institutes of Biomedical Sciences, Fudan University, Shanghai, China. 
      wangxiaofeng@fudan.edu.cn.
AD  - Zhangjiang Fudan International Innovation Centre, Human Phenome Institute, Fudan 
      University, Shanghai, China. wangxiaofeng@fudan.edu.cn.
AD  - National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan 
      University, Shanghai, 201203, China. wangxiaofeng@fudan.edu.cn.
AD  - Department of Epidemiology, Human Phenome Institute, Fudan University, Shanghai, 
      China. wangxiaofeng@fudan.edu.cn.
LA  - eng
GR  - 2018YFC2000400/the National Key R&D Program of China/
GR  - 2018YFC2002000/the National Key R&D Program of China/
GR  - 81670465/the National Natural Science Foundation of China/
GR  - 81600577/the National Natural Science Foundation of China/
GR  - 2017SHZDZX01/Shanghai Municipal Science and Technology Major Project/
GR  - 32288101/National Science Foundation of China/
GR  - 2019-I2M-5-066/CAMS Innovation Fund for Medical Sciences/
PT  - Journal Article
DEP - 20230718
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
SB  - IM
MH  - Aged
MH  - Humans
MH  - *Activities of Daily Living/psychology
MH  - *Aging
MH  - East Asian People
MH  - *Longevity
MH  - Retrospective Studies
MH  - Functional Status
OTO - NOTNLM
OT  - Functional ability
OT  - ICOPE
OT  - Intrinsic capacity
OT  - Trajectories
EDAT- 2023/07/18 01:09
MHDA- 2023/09/27 06:42
CRDT- 2023/07/17 23:30
PHST- 2023/04/24 00:00 [received]
PHST- 2023/06/27 00:00 [accepted]
PHST- 2023/09/27 06:42 [medline]
PHST- 2023/07/18 01:09 [pubmed]
PHST- 2023/07/17 23:30 [entrez]
AID - 10.1007/s40520-023-02489-6 [pii]
AID - 10.1007/s40520-023-02489-6 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2023 Oct;35(10):2061-2068. doi: 10.1007/s40520-023-02489-6. 
      Epub 2023 Jul 18.