PMID- 37462128
OWN - NLM
STAT- MEDLINE
DCOM- 20230719
LR  - 20230719
IS  - 0048-7449 (Print)
IS  - 0048-7449 (Linking)
VI  - 75
IP  - 2
DP  - 2023 Jul 17
TI  - A case of Sjogren syndrome and anti-neutrophil cytoplasmic antibody-associated 
      vasculitis.
LID - 10.4081/reumatismo.2023.1564 [doi]
AB  - Sjogren's syndrome (SS) is a rare disease with the highest reported prevalence of 
      0.01-0.09%. Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is 
      another rare auto-immune disease (prevalence of 0.0009-0.01%). The co-occurrence 
      of these two separate clinical entities in one patient might rarely be 
      encountered as an overlap syndrome. Here, we present the case of a 60-year-old 
      female patient who had complaints of headache, nausea, weakness, gritty sensation 
      in her eyes, and dry mouth [unstimulated saliva production of 0.033 mL/minute 
      (normal; >0.1 mL/minute)] with a blood pressure of 190/110 mmHg, hypertensive 
      retinopathy, proteinuric kidney disease, positivity of myeloperoxidase 
      anti-neutrophil cytoplasmic antibodies, anti-Ro-52, anti-Ro, and anti-La 
      antibodies. Pauci-immune crescentic proliferative glomerulonephritis was found in 
      a kidney biopsy and successfully treated with cyclophosphamide and 
      methylprednisolone. The co-occurrence of these diseases was first reported in 
      1992 by Bottinger et al. Since then, nearly 37 cases of SS and AAV have been 
      reported. By reporting this case of primary SS and AAV, we emphasize the 
      importance of auto-antibody tests in searching for the etiology of patients with 
      proteinuria.
FAU - Kaynar, K
AU  - Kaynar K
AD  - Department of Nephrology, School of Medicine, Karadeniz Technical University, 
      Trabzon. kkaynar@yahoo.com.
FAU - Guvercin, B
AU  - Guvercin B
AD  - Department of Nephrology, School of Medicine, Karadeniz Technical University, 
      Trabzon. beeeyhan@hotmail.com.
FAU - Sengor, A
AU  - Sengor A
AD  - Department of Nephrology, School of Medicine, Karadeniz Technical University, 
      Trabzon. atakansengor@gmail.com.
FAU - Mungan, S
AU  - Mungan S
AD  - Department of Pathology, School of Medicine, Karadeniz Technical University, 
      Trabzon. drsevdegul@gmail.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20230717
PL  - Italy
TA  - Reumatismo
JT  - Reumatismo
JID - 0401302
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Antibodies, Antinuclear)
SB  - IM
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/complications/diagnosis/drug therapy
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Antibodies, Antinuclear
MH  - *Glomerulonephritis/diagnosis/drug therapy/etiology
MH  - *Sjogren's Syndrome/complications/diagnosis/drug therapy
MH  - Headache/etiology
MH  - Nausea/etiology
MH  - Muscle Weakness/etiology
MH  - *Proteinuria/etiology
EDAT- 2023/07/18 13:09
MHDA- 2023/07/19 06:43
CRDT- 2023/07/18 06:37
PHST- 2023/02/08 00:00 [received]
PHST- 2023/05/26 00:00 [accepted]
PHST- 2023/07/19 06:43 [medline]
PHST- 2023/07/18 13:09 [pubmed]
PHST- 2023/07/18 06:37 [entrez]
AID - 10.4081/reumatismo.2023.1564 [doi]
PST - epublish
SO  - Reumatismo. 2023 Jul 17;75(2). doi: 10.4081/reumatismo.2023.1564.