PMID- 37462131
OWN - NLM
STAT- MEDLINE
DCOM- 20230719
LR  - 20230719
IS  - 0048-7449 (Print)
IS  - 0048-7449 (Linking)
VI  - 75
IP  - 2
DP  - 2023 Jul 17
TI  - Clinical features and genetic biomarkers associated with different phenotypes of 
      systemic lupus erythematosus in Paraguayan patients.
LID - 10.4081/reumatismo.2023.1541 [doi]
AB  - Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized 
      by a heterogeneous clinical picture that makes the diagnosis and follow-up of 
      these patients difficult. This study aimed to identify correlations between 
      clinical, immunological, and genetic biomarkers and clinical manifestations in 
      SLE. A retrospective study of data from medical records and immunological and 
      genetic studies of SLE patients in Paraguay was carried out. A descriptive 
      analysis was performed based on the type of variable. Human leukocyte antigen 
      (HLA) allele frequencies (DPA1, DPB1, DQA1, DQB1, and DRB1) were calculated, and 
      univariate logistic regression analyses were performed between each of the 
      explanatory variables and the presence or absence of each phenotype. Odds ratios, 
      95% confidence intervals, and p values were recorded. Associations with p<0.05 
      were considered statistically significant. 104 SLE patients were included: 86% 
      were female, with a mean age of 32.80+/-10.36 years. An association was identified 
      between anti-double stranded DNA (anti-dsDNA) and the presence of the renal 
      phenotype and between anti-dsDNA and the absence of the joint and hematological 
      phenotypes. Immunoglobulin M isotype rheumatoid factor was associated with the 
      absence of a renal phenotype. HLA-DQB1*02:02 and HLA-DRB1*07:01 were associated 
      with the cutaneous phenotype. An association was identified between age at 
      disease onset over 30 years and the presence of the joint phenotype. No other 
      associations were identified. Potential clinical, immunological, and genetic 
      biomarkers of phenotypes have been identified in SLE Paraguayan patients.
FAU - Acosta-Colman, I
AU  - Acosta-Colman I
AD  - Department of Rheumatology, Faculty of Medical Sciences, National University of 
      Asuncion, San Lorenzo. dr.acostacolman@gmail.com.
FAU - Morel, Z
AU  - Morel Z
AD  - Department of Rheumatology, Faculty of Medical Sciences, National University of 
      Asuncion, San Lorenzo. zoiloma@hotmail.com.
FAU - Ayala Lugo, A
AU  - Ayala Lugo A
AD  - Molecular Genetics Laboratory, Health Sciences Research Institute, National 
      University of Asuncion, San Lorenzo. dr.acostacolman@gmail.com.
FAU - Jolly, V
AU  - Jolly V
AD  - Molecular Genetics Laboratory, Health Sciences Research Institute, National 
      University of Asuncion, San Lorenzo. dr.acostacolman@gmail.com.
FAU - De Guillen, I
AU  - De Guillen I
AD  - Production Laboratory, Heath Sciences Research Institute, National University of 
      Asuncion, San Lorenzo. dr.acostacolman@gmail.com.
FAU - Langjahr, P
AU  - Langjahr P
AD  - Production Laboratory, Heath Sciences Research Institute, National University of 
      Asuncion, San Lorenzo. dr.acostacolman@gmail.com.
FAU - Vazquez, M
AU  - Vazquez M
AD  - Department of Rheumatology, Faculty of Medical Sciences, National University of 
      Asuncion, San Lorenzo. dr.acostacolman@gmail.com.
FAU - Martinez de Filartiga, M T
AU  - Martinez de Filartiga MT
AD  - Curie Laboratory, Asuncion. dr.acostacolman@gmail.com.
FAU - Acosta, M E
AU  - Acosta ME
AD  - Production Laboratory, Heath Sciences Research Institute, National University of 
      Asuncion, San Lorenzo. dr.acostacolman@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230717
PL  - Italy
TA  - Reumatismo
JT  - Reumatismo
JID - 0401302
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Young Adult
MH  - Alleles
MH  - Biomarkers
MH  - Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/genetics
MH  - *Lupus Erythematosus, Systemic/diagnosis/ethnology/genetics
MH  - Paraguay/epidemiology
MH  - Phenotype
MH  - Retrospective Studies
MH  - Middle Aged
EDAT- 2023/07/18 13:09
MHDA- 2023/07/19 06:43
CRDT- 2023/07/18 06:37
PHST- 2022/12/06 00:00 [received]
PHST- 2023/06/02 00:00 [accepted]
PHST- 2023/07/19 06:43 [medline]
PHST- 2023/07/18 13:09 [pubmed]
PHST- 2023/07/18 06:37 [entrez]
AID - 10.4081/reumatismo.2023.1541 [doi]
PST - epublish
SO  - Reumatismo. 2023 Jul 17;75(2). doi: 10.4081/reumatismo.2023.1541.