PMID- 37462760
OWN - NLM
STAT- Publisher
LR  - 20230810
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
DP  - 2023 Jul 18
TI  - Programmed death-ligand 1 and tumor-infiltrating lymphocytes (TILs) - low TIL 
      density may predict poorer long-term prognosis in T1 laryngeal cancer.
LID - 10.1007/s00428-023-03586-7 [doi]
AB  - We evaluated the prognostic role of programmed death-ligand 1 (PD-L1) and 
      tumor-infiltrating lymphocytes (TILs) in T1 glottic laryngeal squamous cell 
      carcinoma (LSCC). T1 glottic LSCC patients (n = 174) treated at five Finnish 
      university hospitals between 2003 and 2013 were included. Tissue microarray (TMA) 
      blocks were used for PD-L1 immunohistochemistry. TILs were scored from 
      intratumoral and stromal regions in whole tissue sections. Of 174 patients, 92 
      (53%) had negative, 66 (38%) intermediate, and 16 (9%) high PD-L1 levels. Of 80 
      patients whose TILs were analyzed, 50 (63%) had low and 30 (38%) high stromal TIL 
      density. Patients with a local recurrence or a new primary tumor of the larynx 
      had lower TIL density than had other patients (p = 0.047). High PD-L1 expression 
      with low stromal TIL density was associated with inferior 5-year disease-specific 
      survival (85% vs. 100%, p = 0.02). In conclusion, in patients treated for T1 
      glottic LSCC, low stromal TIL density was associated with local recurrences and 
      new primary tumors of the larynx. High PD-L1 expression with low stromal TIL 
      density may be associated with worse survival in T1 glottic LSCC.
CI  - (c) 2023. The Author(s).
FAU - Pakkanen, Pihla
AU  - Pakkanen P
AUID- ORCID: 0000-0002-0009-8146
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki 
      and Helsinki University Hospital, Helsinki, Finland. pihla.pakkanen@helsinki.fi.
FAU - Ilmarinen, Taru
AU  - Ilmarinen T
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki 
      and Helsinki University Hospital, Helsinki, Finland.
FAU - Halme, Elina
AU  - Halme E
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Tampere 
      and Tampere University Hospital, Tampere, Finland.
FAU - Irjala, Heikki
AU  - Irjala H
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Turku 
      and Turku University Hospital, Turku, Finland.
FAU - Koivunen, Petri
AU  - Koivunen P
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Oulu and 
      Oulu University Hospital, Oulu, Finland.
FAU - Pukkila, Matti
AU  - Pukkila M
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Eastern 
      Finland and Kuopio University Hospital, Kuopio, Finland.
FAU - Ventela, Sami
AU  - Ventela S
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Turku 
      and Turku University Hospital, Turku, Finland.
FAU - Almangush, Alhadi
AU  - Almangush A
AD  - Department of Pathology, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Birkman, Eva-Maria
AU  - Birkman EM
AD  - Department of Pathology, University of Turku and Turku University Hospital, 
      Turku, Finland.
FAU - Lindgren, Outi
AU  - Lindgren O
AD  - Department of Pathology, University of Oulu and Oulu University Hospital, Oulu, 
      Finland.
FAU - Pohjolainen, Virva
AU  - Pohjolainen V
AD  - Fimlab Laboratories, Department of Pathology, Tampere University Hospital, 
      Tampere, Finland.
FAU - Sjoblom, Nelli
AU  - Sjoblom N
AD  - Department of Pathology, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Haglund, Caj
AU  - Haglund C
AD  - Department of Pathology, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
AD  - Department of Surgery, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Hagstrom, Jaana
AU  - Hagstrom J
AD  - Department of Pathology, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
AD  - Department of Oral Pathology and Radiology, University of Turku, Turku, Finland.
FAU - Aaltonen, Leena-Maija
AU  - Aaltonen LM
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki 
      and Helsinki University Hospital, Helsinki, Finland.
LA  - eng
PT  - Journal Article
DEP - 20230718
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
SB  - IM
EIN - Virchows Arch. 2023 Aug 9;:. PMID: 37555983
OTO - NOTNLM
OT  - Early laryngeal cancer
OT  - Prognosis
OT  - Programmed death-ligand 1
OT  - T1 glottic cancer
OT  - Tumor-infiltrating lymphocytes
EDAT- 2023/07/18 13:08
MHDA- 2023/07/18 13:08
CRDT- 2023/07/18 11:07
PHST- 2023/03/08 00:00 [received]
PHST- 2023/06/25 00:00 [accepted]
PHST- 2023/05/26 00:00 [revised]
PHST- 2023/07/18 13:08 [pubmed]
PHST- 2023/07/18 13:08 [medline]
PHST- 2023/07/18 11:07 [entrez]
AID - 10.1007/s00428-023-03586-7 [pii]
AID - 10.1007/s00428-023-03586-7 [doi]
PST - aheadofprint
SO  - Virchows Arch. 2023 Jul 18. doi: 10.1007/s00428-023-03586-7.