PMID- 37463634
OWN - NLM
STAT- MEDLINE
DCOM- 20230904
LR  - 20231213
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Print)
IS  - 0887-2333 (Linking)
VI  - 92
DP  - 2023 Oct
TI  - Assessment of Scanning Mobility Particle Sizer (SMPS) for online monitoring of 
      delivered dose in an in vitro aerosol exposure system.
PG  - 105650
LID - S0887-2333(23)00099-1 [pii]
LID - 10.1016/j.tiv.2023.105650 [doi]
AB  - Real-time monitoring of dosimetry is critical to mitigating the constraints of 
      offline measurements. To address this need, the use of the Scanning Mobility 
      Particle Sizer (SMPS) to estimate the dose delivered through the Dosimetric 
      Aerosol in Vitro Inhalation Device (DAVID) was assessed. CuO nanoparticles 
      suspended in ethanol at different concentrations (0.01-10 mg/mL) were aerosolized 
      using a Collison nebulizer and diluted with air at a ratio of either 1:3 (setup 
      1) or 1:18 (setup 2). From the aerosol volume concentrations measured by the 
      SMPS, density of CuO (6.4 g/cm(3)), collection time (5-30 min), flow rate (0.5 
      LPM) and deposition area (0.28 cm(2)), the mass doses (Dose(SMPS)) were observed 
      to increase exponentially over time and ranged from 0.02 +/- 0.001 to 
      84.75 +/- 3.49 mug/cm(2). The doses calculated from the Cu concentrations determined 
      by Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES) (Dose(ICP)) 
      also increased exponentially over time (0.01 +/- 0.01-97.25 +/- 1.30 mug/cm(2)). 
      Regression analysis between Dose(ICP) and Dose(SMPS) showed R(2) >/= 0.90 for 
      0.1-10 mg/mL. As demonstrated, the SMPS can be used to monitor the delivered dose 
      in real-time, and controlled delivery of mass doses with a 226-fold range can be 
      attained in </=30 min in DAVID by adjusting the nebulizer concentration, dilution 
      air and time.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Nannu Shankar, Sripriya
AU  - Nannu Shankar S
AD  - Department of Environmental Engineering Sciences, University of Florida, 
      Gainesville, USA. Electronic address: snannushankar@ufl.edu.
FAU - Mital, Kiran
AU  - Mital K
AD  - Department of Mechanical & Aerospace Engineering, University of Florida, 
      Gainesville, USA.
FAU - Le, Eric
AU  - Le E
AD  - Department of Chemical Engineering, University of Florida, Gainesville, USA.
FAU - Lewis, Gregory S
AU  - Lewis GS
AD  - Aerosol Dynamics Inc., Berkeley, USA.
FAU - Eiguren-Fernandez, Arantzazu
AU  - Eiguren-Fernandez A
AD  - Aerosol Dynamics Inc., Berkeley, USA.
FAU - Sabo-Attwood, Tara
AU  - Sabo-Attwood T
AD  - Department of Environmental and Global Health, University of Florida, 
      Gainesville, USA.
FAU - Wu, Chang-Yu
AU  - Wu CY
AD  - Department of Environmental Engineering Sciences, University of Florida, 
      Gainesville, USA; Department of Chemical, Environmental, and Materials 
      Engineering, University of Miami, Coral Gables, USA. Electronic address: 
      cywu@ufl.edu.
LA  - eng
GR  - R44 ES030649/ES/NIEHS NIH HHS/United States
GR  - TL1 TR001428/TR/NCATS NIH HHS/United States
GR  - UL1 TR001427/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20230716
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with 
      BIBRA
JID - 8712158
RN  - V1XJQ704R4 (cupric oxide)
RN  - 0 (Aerosols)
SB  - IM
MH  - Particle Size
MH  - Aerosols/chemistry
MH  - *Nanoparticles
PMC - PMC10714344
MID - NIHMS1947328
OTO - NOTNLM
OT  - Aerosol delivery
OT  - Condensational growth
OT  - Dose prediction
OT  - Dosimetry
COIS- Declaration of Competing Interest Aerosol Dynamics Inc. holds the rights to the 
      patent underlying the laminar flow, water-based condensational particle growth 
      for concentrated collection of airborne particles (US-20140060155)
EDAT- 2023/07/19 01:06
MHDA- 2023/09/04 06:42
PMCR- 2024/10/01
CRDT- 2023/07/18 19:12
PHST- 2022/10/31 00:00 [received]
PHST- 2023/06/02 00:00 [revised]
PHST- 2023/07/12 00:00 [accepted]
PHST- 2024/10/01 00:00 [pmc-release]
PHST- 2023/09/04 06:42 [medline]
PHST- 2023/07/19 01:06 [pubmed]
PHST- 2023/07/18 19:12 [entrez]
AID - S0887-2333(23)00099-1 [pii]
AID - 10.1016/j.tiv.2023.105650 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2023 Oct;92:105650. doi: 10.1016/j.tiv.2023.105650. Epub 2023 
      Jul 16.