PMID- 37463966
OWN - NLM
STAT- MEDLINE
DCOM- 20230721
LR  - 20230721
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Jul 18
TI  - The association between urinary phthalate metabolites and serum thyroid function 
      in US adolescents.
PG  - 11601
LID - 10.1038/s41598-023-38644-2 [doi]
LID - 11601
AB  - The aim was to investigate the association between mixed exposure to phthalates 
      and serum thyroid function among US adolescents. The study used 2007-2008 survey 
      data from the National Health and Nutrition Examination Survey (NHANES). Data on 
      urinary phthalates metabolites and serum thyroid function indicators were 
      collected. The weighted multivariable linear regression models and Bayesian 
      kernel machine regression (BKMR) analyses were used to analyze the relationship 
      between phthalates metabolites and thyroid function. A total of 356 adolescents 
      aged 12-19 years were included in the analysis. Linear regression models showed 
      that mono-(carboxyisoctyl) phthalate (MCOP) was positively correlated with total 
      triiodothyronine (TT3) (beta = 0.045, 95% confidence interval [CI] 0.022, 0.068) and 
      thyroid stimulating hormone (TSH) (beta = 0.1461, 95% CI 0.059, 0.232), while 
      mono-(carboxyisononyl) phthalate (MCNP) was negatively correlated with TSH 
      (beta = - 0.119, 95% CI - 0.196, - 0.042). BKMR analyses showed phthalate 
      metabolites mixtures have significantly positive overall effect on TT3. Exposure 
      to phthalate mixtures might be positively correlated with increased TT3 serum 
      level in US adolescents. The study provided evidence for the association between 
      mixed phthalates exposure and thyroid health in adolescent population.
CI  - (c) 2023. The Author(s).
FAU - Xiang, Shi-Ting
AU  - Xiang ST
AD  - Hunan Children's Research Institute (HCRI), Hunan Children's Hospital, Ziyuan RD 
      86, Changsha, 410007, China.
FAU - Cao, Yuhan
AU  - Cao Y
AD  - Hunan Children's Research Institute (HCRI), Hunan Children's Hospital, Ziyuan RD 
      86, Changsha, 410007, China.
AD  - Department of Occupational and Environmental Health, Xiangya School of Public 
      Health, Central South University, Xiangya RD 110, Changsha, 410078, China.
FAU - Dong, Jie
AU  - Dong J
AD  - Hunan Children's Research Institute (HCRI), Hunan Children's Hospital, Ziyuan RD 
      86, Changsha, 410007, China.
FAU - Li, Chao
AU  - Li C
AD  - Department of Epidemiology and Medical Statistics, Xiangya School of Public 
      Health, Central South University, Xiangya RD 110, Changsha, 410078, China.
FAU - Qiu, Jun
AU  - Qiu J
AD  - Hunan Children's Research Institute (HCRI), Hunan Children's Hospital, Ziyuan RD 
      86, Changsha, 410007, China.
FAU - Li, Xun
AU  - Li X
AD  - Hunan Children's Research Institute (HCRI), Hunan Children's Hospital, Ziyuan RD 
      86, Changsha, 410007, China. li.xunxx@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230718
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 6O7F7IX66E (phthalic acid)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Phthalic Acids)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Adolescent
MH  - Humans
MH  - Thyroid Gland/metabolism
MH  - Nutrition Surveys
MH  - *Environmental Pollutants/analysis
MH  - Bayes Theorem
MH  - *Phthalic Acids/metabolism
MH  - Thyrotropin
MH  - Environmental Exposure/adverse effects/analysis
PMC - PMC10354030
COIS- The authors declare no competing interests.
EDAT- 2023/07/19 01:06
MHDA- 2023/07/21 06:44
PMCR- 2023/07/18
CRDT- 2023/07/18 23:20
PHST- 2023/03/16 00:00 [received]
PHST- 2023/07/12 00:00 [accepted]
PHST- 2023/07/21 06:44 [medline]
PHST- 2023/07/19 01:06 [pubmed]
PHST- 2023/07/18 23:20 [entrez]
PHST- 2023/07/18 00:00 [pmc-release]
AID - 10.1038/s41598-023-38644-2 [pii]
AID - 38644 [pii]
AID - 10.1038/s41598-023-38644-2 [doi]
PST - epublish
SO  - Sci Rep. 2023 Jul 18;13(1):11601. doi: 10.1038/s41598-023-38644-2.