PMID- 37465556
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230720
IS  - 1178-7074 (Print)
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 16
DP  - 2023
TI  - Serum IL-38 Level Was Associated with Incidence of MACE in the STEMI Patients.
PG  - 2987-2997
LID - 10.2147/IJGM.S417471 [doi]
AB  - BACKGROUND: The relationship between serum IL-38 and major adverse cardiovascular 
      events (MACE) in patients with ST elevation myocardial infarction (STEMI) remains 
      unclear. METHODS: In the present study, 589 STEMI patients were included, the 
      serum level of IL-38 was measured. The median follow-up time was 720 days, the 
      STEMI patients were divided into high IL-38 (IL-38>6.49ng/mL) and low IL-38 
      groups (IL-38</=6.49ng/mL) to compare the probability of MACE. RESULTS: Plasma 
      IL-38 levels were significantly lower in STEMI patients than in SAP patients 
      (4.0+/-2.2 vs 6.9+/-3.2 ng/mL, P < 0.001). Ninety-three STEMI patients met the 
      defined MACE study endpoint. The incidence of MACE was significantly lower in 
      patients with high IL-38 group than in patients with low IL-38 group (7.8% vs 
      23.7%, P < 0.001). Low plasma IL-38 levels were independently associated with the 
      occurrence of MACE (OR = 0.90, P < 0.001). CONCLUSION: We get a conclusion that 
      low plasma levels of IL-38 are independently associated with the occurrence of 
      MACE.
CI  - (c) 2023 Lu et al.
FAU - Lu, Chengbo
AU  - Lu C
AD  - Department of Cardiology, 1st Affiliated Hospital of Jiamusi University, Jiamusi, 
      Heilongjiang, People's Republic of China.
FAU - Zhou, Fanghui
AU  - Zhou F
AD  - Department of Hematology, 2nd Affiliated Hospital of Harbin Medical University, 
      Harbin, Heilongjiang, People's Republic of China.
FAU - Xian, Huimin
AU  - Xian H
AD  - Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, 
      Harbin, Heilongjiang, People's Republic of China.
FAU - Sun, Siyuan
AU  - Sun S
AD  - Department of Cardiology, People's Hospital of Taihe County, Taihe, Anhui, 
      People's Republic of China.
FAU - Yue, Jingkun
AU  - Yue J
AD  - Department of Cardiology, People's Hospital of Taihe County, Taihe, Anhui, 
      People's Republic of China.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Department of Gynaecology and Obstetrics, 1st Affiliated Hospital of Jiamusi 
      University, Jiamusi, Heilongjiang, People's Republic of China.
FAU - Zhao, Qi
AU  - Zhao Q
AD  - Department of Cardiology, 1st Affiliated Hospital of Harbin Medical University, 
      Harbin, Heilongjiang, People's Republic of China.
FAU - Luo, Xing
AU  - Luo X
AUID- ORCID: 0000-0003-1096-6629
AD  - Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, 
      Harbin, Heilongjiang, People's Republic of China.
FAU - Li, Yang
AU  - Li Y
AD  - Department of Cardiology, 4th Affiliated Hospital of Harbin Medical University, 
      Harbin, Heilongjiang, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230712
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC10350401
OTO - NOTNLM
OT  - IL-38
OT  - MACE
OT  - SAP
OT  - STEMI
OT  - inflammatory response
COIS- The authors report no conflicts of interest in this work.
EDAT- 2023/07/19 06:42
MHDA- 2023/07/19 06:43
PMCR- 2023/07/12
CRDT- 2023/07/19 04:03
PHST- 2023/04/16 00:00 [received]
PHST- 2023/07/03 00:00 [accepted]
PHST- 2023/07/19 06:43 [medline]
PHST- 2023/07/19 06:42 [pubmed]
PHST- 2023/07/19 04:03 [entrez]
PHST- 2023/07/12 00:00 [pmc-release]
AID - 417471 [pii]
AID - 10.2147/IJGM.S417471 [doi]
PST - epublish
SO  - Int J Gen Med. 2023 Jul 12;16:2987-2997. doi: 10.2147/IJGM.S417471. eCollection 
      2023.