PMID- 37468868 OWN - NLM STAT- MEDLINE DCOM- 20230721 LR - 20231122 IS - 1471-2318 (Electronic) IS - 1471-2318 (Linking) VI - 23 IP - 1 DP - 2023 Jul 19 TI - Moderate elevation of serum uric acid levels improves short-term functional outcomes of ischemic stroke in patients with type 2 diabetes mellitus. PG - 445 LID - 10.1186/s12877-023-04141-4 [doi] LID - 445 AB - BACKGROUND: Serum uric acid (SUA), an end-product of purine catabolism diffused in the blood, is positively associated with the risk of type 2 diabetes mellitus (T2DM). However, in the T2DM population, the association of SUA fluctuation ([Formula: see text]SUA) with the functional outcome of ischemic stroke (IS) is still unclear. Accordingly, this study aimed to assess the correlation between [Formula: see text]SUA and short-term IS functional outcomes in T2DM patients. METHODS: All T2DM patients diagnosed with IS in the China National Stroke Registry III were included. [Formula: see text]SUA, which was defined as the difference between the SUA levels at baseline and 3 months after symptom onset, was classified into two groups, i.e., elevated [Formula: see text]SUA ([Formula: see text]SUA > 0) and reduced [Formula: see text]SUA ([Formula: see text]SUA [Formula: see text] 0). The outcomes measured using the Modified Rankin Scale (mRS) were scored from 0 to 6, and poor functional outcome was defined as an mRS score of 3-6 at 3 months after IS. RESULTS: Among the 1255 participants (mean age: 61.6 +/- 9.8 years), 64.9% were men. Patients with elevated [Formula: see text]SUA had a lower incidence of poor functional outcomes at 3 months. Compared with reduced [Formula: see text]SUA, elevated [Formula: see text]SUA at 0-50 mumol/L (odds ratio [OR] = 0.46, 95% confidence interval [CI] = 0.28-0.78, p = 0.004) and 50-100 mumol/L (OR = 0.40, 95% CI = 0.21-0.77, p = 0.006) was significantly correlated with a reduced risk of poor functional outcomes at 3 months. CONCLUSION: This study showed that a moderate increase in [Formula: see text]SUA in the range of 0-100 mumol/L at 3 months after IS might be beneficial in T2DM adults and more studies are warranted to confirm this. CI - (c) 2023. The Author(s). FAU - Dai, Yalun AU - Dai Y AD - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China. FAU - Jiang, Yingyu AU - Jiang Y AD - China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China. FAU - Zhang, Luping AU - Zhang L AD - Department of Obstetrics and Gynecology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. FAU - Qiu, Xin AU - Qiu X AD - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China. FAU - Gu, Hongqiu AU - Gu H AD - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China. FAU - Jiang, Yong AU - Jiang Y AD - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China. FAU - Meng, Xia AU - Meng X AD - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China. FAU - Li, Zixiao AU - Li Z AD - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China. AD - Chinese Institute for Brain Research, Beijing, China. FAU - Wang, Yongjun AU - Wang Y AD - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. yongjunwang@ncrcnd.org.cn. AD - China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China. yongjunwang@ncrcnd.org.cn. AD - Chinese Institute for Brain Research, Beijing, China. yongjunwang@ncrcnd.org.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230719 PL - England TA - BMC Geriatr JT - BMC geriatrics JID - 100968548 RN - 268B43MJ25 (Uric Acid) SB - IM EIN - BMC Geriatr. 2023 Sep 26;23(1):601. PMID: 37752427 MH - Male MH - Humans MH - Aged MH - Female MH - *Diabetes Mellitus, Type 2/complications/diagnosis/epidemiology MH - Uric Acid MH - *Ischemic Stroke/diagnosis/epidemiology/therapy MH - *Stroke/diagnosis/epidemiology/therapy MH - Prognosis MH - Risk Factors PMC - PMC10357838 OTO - NOTNLM OT - Diabetes mellitus OT - Functional outcome OT - Ischemic stroke OT - Prognosis OT - Serum uric acid COIS- The authors declare no competing interests. EDAT- 2023/07/20 01:06 MHDA- 2023/07/21 06:43 PMCR- 2023/07/19 CRDT- 2023/07/19 23:41 PHST- 2023/02/26 00:00 [received] PHST- 2023/06/28 00:00 [accepted] PHST- 2023/07/21 06:43 [medline] PHST- 2023/07/20 01:06 [pubmed] PHST- 2023/07/19 23:41 [entrez] PHST- 2023/07/19 00:00 [pmc-release] AID - 10.1186/s12877-023-04141-4 [pii] AID - 4141 [pii] AID - 10.1186/s12877-023-04141-4 [doi] PST - epublish SO - BMC Geriatr. 2023 Jul 19;23(1):445. doi: 10.1186/s12877-023-04141-4.