PMID- 3746936
OWN - NLM
STAT- MEDLINE
DCOM- 19861010
LR  - 20161123
IS  - 0098-4108 (Print)
IS  - 0098-4108 (Linking)
VI  - 19
IP  - 1
DP  - 1986
TI  - Kidney morphology and function in the young of rats malnourished and exposed to 
      nitrofen during pregnancy.
PG  - 1-21
AB  - The separate and combined effects of prenatal protein deficiency (6% casein) and 
      prenatal nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether) exposure (12.5 mg/kg 
      on gestational d 7-21) on renal morphology in the 21-d fetal and postnatal rat 
      were examined. Body weights and kidney weights were reduced in prenatally 
      protein-deprived (PPD) pups at birth and on postnatal day (PND) 10. Numbers of 
      mature glomeruli, creatinine clearance, water diuresis, and response of 
      antidiuretic hormone (ADH), but not the concentrating ability, were lower in the 
      PPD neonates. These changes suggest that prenatal protein deficiency delays renal 
      development and possibly results in a decrease in glomerular clearance and in 
      tubular response to a water load and to antidiuretic hormone. Prenatal nitrofen 
      exposure reduced body weight and kidney size on PND 0 and 10. An increased 
      incidence of hydronephrosis was indicated in the nitrofen-exposed fetus. Prenatal 
      nitrofen exposure depressed the ability to excrete excess water, the response to 
      ADH, and urine-concentrating ability. The functional deficits indicate tubular 
      dysfunction, but little or no effect on glomerular function, as indicated by the 
      absence of an effect on creatinine clearance. Postnatal survival was reduced to 
      22% by PND in the PPD plus nitrofen pups. Also, prenatal nitrofen exposure 
      increased the susceptibility of the glomeruli in the gestational day (GD) 21 PPD 
      fetus to the adverse effects of prenatal protein deficiency. By PND 10 the toxic 
      effects were of the same order. Renal dysfunction may contribute to the increased 
      mortality in PPD plus nitrofen pups by reducing the ability to respond to stress, 
      but the effects are not sufficiently marked to be considered the primary cause of 
      death.
FAU - Chase-Deesing, C
AU  - Chase-Deesing C
FAU - Kavlock, R J
AU  - Kavlock RJ
FAU - Zeman, F J
AU  - Zeman FJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Toxicol Environ Health
JT  - Journal of toxicology and environmental health
JID - 7513622
RN  - 0 (Herbicides)
RN  - 0 (Phenyl Ethers)
RN  - ENR1LLB0FP (Deamino Arginine Vasopressin)
RN  - N71UYG034A (nitrofen)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Deamino Arginine Vasopressin/pharmacology
MH  - Diuresis/drug effects
MH  - Eating
MH  - Female
MH  - Herbicides/*toxicity
MH  - Kidney/drug effects/pathology/*physiology
MH  - Kidney Concentrating Ability/drug effects
MH  - Litter Size/drug effects
MH  - Organ Size
MH  - Phenyl Ethers/*toxicity
MH  - Pregnancy
MH  - *Pregnancy Complications
MH  - Protein Deficiency/*complications
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1080/15287398609530902 [doi]
PST - ppublish
SO  - J Toxicol Environ Health. 1986;19(1):1-21. doi: 10.1080/15287398609530902.