PMID- 37469479
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230721
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 10
DP  - 2023
TI  - Changes in SedLine-derived processed electroencephalographic parameters during 
      hypothermia in patients undergoing cardiac surgery with cardiopulmonary bypass.
PG  - 1084426
LID - 10.3389/fcvm.2023.1084426 [doi]
LID - 1084426
AB  - OBJECTIVE: Processed electroencephalography (pEEG) is used to monitor 
      depth-of-anesthesia during cardiopulmonary bypass (CPB). The SedLine device has 
      been recently introduced for pEEG monitoring. However, the effect of hypothermia 
      on its parameters during CPB is unknown. Accordingly, we aimed to investigate 
      temperature-induced changes in SedLine-derived pEEG parameters during CPB. 
      DESIGN: Prospective observational study. SETTING: Cardiac surgery operating 
      theatre. PARTICIPANTS: 28 patients undergoing elective cardiac surgery with CPB. 
      INTERVENTIONS: We continuously measured patient state index (PSI), suppression 
      ratio (SR), bilateral spectral edge frequency (SEF) and temperature. We used 
      linear mixed modelling with fixed and random effects to study the interactions 
      between pEEG parameters and core temperature. MEASUREMENTS AND MAIN RESULTS: 
      During CPB maintenance, the median temperature was 32.1 degrees C [interquartile range 
      (IQR): 29.8-33.6] at the end of cooling and 32.8 degrees C (IQR: 30.1-34.0) at rewarming 
      initiation. For each degree Celsius change in temperature during cooling and 
      rewarming the PSI either decreased by 0.8 points [95% confidence interval (CI): 
      0.7-1.0; p < 0.001] or increased by 0.7 points (95% CI: 0.6-0.8; p < 0.001). The 
      SR increased by 2.9 (95% CI: 2.3-3.4); p < 0.001) during cooling and decreased by 
      2.2 (95% CI: 1.7-2.7; p < 0.001) during rewarming. Changes in the SEF were not 
      related to changes in temperature. CONCLUSIONS: During hypothermic CPB, 
      temperature changes led to concordant changes in the PSI. The SR increased during 
      cooling and decreased during rewarming. Clinicians using SedLine for 
      depth-of-anesthesia monitoring should be aware of these effects when interpreting 
      the PSI and SR values.
CI  - (c) 2023 Belletti, Lee, Yanase, Naorungroj, Eastwood, Bellomo and Weinberg.
FAU - Belletti, Alessandro
AU  - Belletti A
AD  - Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.
AD  - Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific 
      Institute, Milan, Italy.
FAU - Lee, Dong-Kyu
AU  - Lee DK
AD  - Department of Anesthesiology and Pain Medicine, Dongguk University Ilsan 
      Hospital, Goyang, Republic of Korea.
FAU - Yanase, Fumitaka
AU  - Yanase F
AD  - Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.
AD  - Australian and New Zealand Intensive Care Research Centre, Monash University, 
      Melbourne, VIC, Australia.
FAU - Naorungroj, Thummaporn
AU  - Naorungroj T
AD  - Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.
AD  - Department of Intensive Care, Siriraj Hospital, Mahidol University, Bangkok, 
      Thailand.
FAU - Eastwood, Glenn M
AU  - Eastwood GM
AD  - Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.
FAU - Bellomo, Rinaldo
AU  - Bellomo R
AD  - Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.
AD  - Australian and New Zealand Intensive Care Research Centre, Monash University, 
      Melbourne, VIC, Australia.
AD  - Department of Critical Care, The University of Melbourne, Melbourne, VIC, 
      Australia.
AD  - Data Analytics Research and Evaluation Centre, The University of Melbourne and 
      The Austin Hospital, Melbourne, VIC, Australia.
FAU - Weinberg, Laurence
AU  - Weinberg L
AD  - Department of Critical Care, The University of Melbourne, Melbourne, VIC, 
      Australia.
AD  - Department of Anaesthesia, Austin Hospital, Heidelberg, VIC, Australia.
LA  - eng
PT  - Journal Article
DEP - 20230704
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC10352607
OTO - NOTNLM
OT  - anesthesia
OT  - cardiac surgery
OT  - cardiopulmonary bypass
OT  - delirium
OT  - electroencephalography
OT  - neuromonitoring
OT  - neuroprotection
OT  - propofol
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/07/20 06:42
MHDA- 2023/07/20 06:43
PMCR- 2023/01/01
CRDT- 2023/07/20 03:54
PHST- 2022/10/30 00:00 [received]
PHST- 2023/06/19 00:00 [accepted]
PHST- 2023/07/20 06:43 [medline]
PHST- 2023/07/20 06:42 [pubmed]
PHST- 2023/07/20 03:54 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2023.1084426 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2023 Jul 4;10:1084426. doi: 10.3389/fcvm.2023.1084426. 
      eCollection 2023.