PMID- 37470222
OWN - NLM
STAT- MEDLINE
DCOM- 20230823
LR  - 20230823
IS  - 2047-4849 (Electronic)
IS  - 2047-4830 (Linking)
VI  - 11
IP  - 17
DP  - 2023 Aug 22
TI  - Co-delivery of vitamin D3 and Lkb1 siRNA by cationic lipid-assisted PEG-PLGA 
      nanoparticles to effectively remodel the immune system in vivo.
PG  - 5931-5941
LID - 10.1039/d3bm00767g [doi]
AB  - The imbalance of the immune system can lead to the occurrence of autoimmune 
      diseases. Controlling and regulating the proliferation and function of effector T 
      (Teff) cells and regulatory T (Treg) cells becomes the key to treating these 
      diseases. Dendritic cells (DCs), as dedicated antigen-presenting cells, play a 
      key role in inducing the differentiation of naive CD4+ T cells. In this study, we 
      designed a cationic lipid-assisted PEG-PLGA nanoparticle (NPs/VD3/siLkb1) to 
      deliver 1,25-dihydroxyvitamin D3 (VD3) and small interfering RNA (siRNA) to DC 
      cells in the draining lymph nodes. By modulating the phenotypic changes of DC 
      cells, this approach expands Treg cells and reduces the occurrence of autoimmune 
      diseases. Thus, this study provides a novel approach to alleviating the 
      occurrence and development of autoimmune diseases while also minimizing the risk 
      of unwanted complications.
FAU - Liu, Haochuan
AU  - Liu H
AUID- ORCID: 0000-0002-3515-4822
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Jilin University, Changchun, Jilin, 130061, China. tsun41@jlu.edu.cn.
AD  - Department of Orthopaedics, China-Japan Union Hospital of Jilin University, 
      Changchun, Jilin, 130031, China.
FAU - Zhang, Yuning
AU  - Zhang Y
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Jilin University, Changchun, Jilin, 130061, China. tsun41@jlu.edu.cn.
AD  - International Center of Future Science, Jilin University, Changchun, Jilin, 
      130015, China.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, Jilin, 130062, China.
FAU - Li, He
AU  - Li H
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Jilin University, Changchun, Jilin, 130061, China. tsun41@jlu.edu.cn.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, Jilin, 130062, China.
FAU - Gao, Xue
AU  - Gao X
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Jilin University, Changchun, Jilin, 130061, China. tsun41@jlu.edu.cn.
FAU - Wang, Jialiang
AU  - Wang J
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Jilin University, Changchun, Jilin, 130061, China. tsun41@jlu.edu.cn.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, Jilin, 130062, China.
FAU - Cong, Xiuxiu
AU  - Cong X
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Jilin University, Changchun, Jilin, 130061, China. tsun41@jlu.edu.cn.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, Jilin, 130062, China.
FAU - Xin, Yanbao
AU  - Xin Y
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Jilin University, Changchun, Jilin, 130061, China. tsun41@jlu.edu.cn.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, Jilin, 130062, China.
FAU - Zhu, Qingsan
AU  - Zhu Q
AUID- ORCID: 0000-0002-9403-832X
AD  - Department of Orthopaedics, China-Japan Union Hospital of Jilin University, 
      Changchun, Jilin, 130031, China.
FAU - Chen, Bing
AU  - Chen B
AD  - Department of Anesthesiology, China-Japan Union Hospital of Jilin University, 
      Changchun, Jilin, 130031, China. chenbing2020@jlu.edu.cn.
FAU - Yang, Yong-Guang
AU  - Yang YG
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Jilin University, Changchun, Jilin, 130061, China. tsun41@jlu.edu.cn.
AD  - International Center of Future Science, Jilin University, Changchun, Jilin, 
      130015, China.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, Jilin, 130062, China.
FAU - Sun, Tianmeng
AU  - Sun T
AUID- ORCID: 0000-0003-2261-4532
AD  - Key Laboratory of Organ Regeneration and Transplantation of Ministry of 
      Education, Jilin University, Changchun, Jilin, 130061, China. tsun41@jlu.edu.cn.
AD  - International Center of Future Science, Jilin University, Changchun, Jilin, 
      130015, China.
AD  - National-local Joint Engineering Laboratory of Animal Models for Human Diseases, 
      Changchun, Jilin, 130062, China.
AD  - State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 
      Changchun, Jilin, 130012, China.
LA  - eng
PT  - Journal Article
DEP - 20230822
PL  - England
TA  - Biomater Sci
JT  - Biomaterials science
JID - 101593571
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - 0 (polyethylene glycol-poly(lactide-co-glycolide))
RN  - 0 (RNA, Small Interfering)
SB  - IM
MH  - Humans
MH  - Cholecalciferol/pharmacology
MH  - Dendritic Cells
MH  - RNA, Small Interfering/genetics
MH  - *Nanoparticles
MH  - *Autoimmune Diseases/drug therapy
EDAT- 2023/07/20 06:42
MHDA- 2023/08/23 06:42
CRDT- 2023/07/20 05:52
PHST- 2023/08/23 06:42 [medline]
PHST- 2023/07/20 06:42 [pubmed]
PHST- 2023/07/20 05:52 [entrez]
AID - 10.1039/d3bm00767g [doi]
PST - epublish
SO  - Biomater Sci. 2023 Aug 22;11(17):5931-5941. doi: 10.1039/d3bm00767g.