PMID- 37471218
OWN - NLM
STAT- MEDLINE
DCOM- 20230915
LR  - 20231024
IS  - 1522-1229 (Electronic)
IS  - 1043-4046 (Linking)
VI  - 47
IP  - 4
DP  - 2023 Dec 1
TI  - Teaching of drug disposition using physiologically based pharmacokinetic modeling 
      software: GastroPlus as an educational tool.
PG  - 718-725
LID - 10.1152/advan.00051.2023 [doi]
AB  - Physiologically based pharmacokinetic (PBPK) modeling requires an understanding 
      of chemical, physiologic, and pharmacokinetic principles. Active learning with 
      PBPK modeling software (GastroPlus) may be useful to teach these scientific 
      principles while also teaching software operation. To examine this issue, a 
      graduate-level course was designed using learning objectives in science, software 
      use, and PBPK model application. These objectives were taught through hands-on 
      PBPK modeling to answer clinically relevant questions. Students demonstrated 
      proficient use of software, based on their responses to these questions, and 
      showed an improved understanding of scientific principles on a pre- and 
      post-course assessment. These outcomes support the effectiveness of simultaneous 
      teaching of interdependent software and science.NEW & NOTEWORTHY Physiologically 
      based pharmacokinetic (PBPK) modeling is a major growth area in drug development, 
      regulatory submissions, and clinical applications. There is a demand for experts 
      in this area with multidisciplinary backgrounds. In this article, we describe a 
      course designed to teach PBPK modeling and the underlying scientific principles 
      in parallel.
FAU - Morningstar-Kywi, Noam
AU  - Morningstar-Kywi N
AUID- ORCID: 0000-0002-1648-4463
AD  - Department of Pharmacology and Pharmaceutical Sciences, University of Southern 
      California Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, Los 
      Angeles, California, United States.
AD  - Simulations Plus, Inc., Lancaster, California, United States.
FAU - Morris, Denise N
AU  - Morris DN
AD  - Simulations Plus, Inc., Lancaster, California, United States.
FAU - Romero, Rebecca M
AU  - Romero RM
AD  - Department of Pharmacology and Pharmaceutical Sciences, University of Southern 
      California Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, Los 
      Angeles, California, United States.
FAU - Haworth, Ian S
AU  - Haworth IS
AUID- ORCID: 0000-0002-3873-0899
AD  - Department of Pharmacology and Pharmaceutical Sciences, University of Southern 
      California Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, Los 
      Angeles, California, United States.
LA  - eng
PT  - Journal Article
DEP - 20230720
PL  - United States
TA  - Adv Physiol Educ
JT  - Advances in physiology education
JID - 100913944
SB  - IM
CIN - Adv Physiol Educ. 2023 Dec 1;47(4):888. PMID: 37847113
MH  - Humans
MH  - *Models, Biological
MH  - *Software
MH  - Structure-Activity Relationship
MH  - Problem-Based Learning
OTO - NOTNLM
OT  - PBPK modeling
OT  - biopharmaceutics
OT  - education
OT  - pharmacokinetics
OT  - teaching
EDAT- 2023/07/20 19:14
MHDA- 2023/09/15 06:42
CRDT- 2023/07/20 12:33
PHST- 2023/09/15 06:42 [medline]
PHST- 2023/07/20 19:14 [pubmed]
PHST- 2023/07/20 12:33 [entrez]
AID - 10.1152/advan.00051.2023 [doi]
PST - ppublish
SO  - Adv Physiol Educ. 2023 Dec 1;47(4):718-725. doi: 10.1152/advan.00051.2023. Epub 
      2023 Jul 20.