PMID- 37471699
OWN - NLM
STAT- MEDLINE
DCOM- 20230918
LR  - 20230919
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 44
IP  - 15
DP  - 2023 Oct 15
TI  - Planning ahead: Predictable switching recruits task-active and resting-state 
      networks.
PG  - 5030-5046
LID - 10.1002/hbm.26430 [doi]
AB  - Switching is a difficult cognitive process characterised by costs in task 
      performance; specifically, slowed responses and reduced accuracy. It is 
      associated with the recruitment of a large coalition of task-positive regions 
      including those referred to as the multiple demand cortex (MDC). The neural 
      correlates of switching not only include the MDC, but occasionally the default 
      mode network (DMN), a characteristically task-negative network. To unpick the 
      role of the DMN during switching we collected fMRI data from 24 participants 
      playing a switching paradigm that perturbed predictability (i.e., cognitive load) 
      across three switch dimensions-sequential, perceptual, and spatial 
      predictability. We computed the activity maps unique to switch vs. stay trials 
      and all switch dimensions, then evaluated functional connectivity under these 
      switch conditions by computing the pairwise mutual information functional 
      connectivity (miFC) between regional timeseries. Switch trials exhibited an 
      expected cost in reaction time while sequential predictability produced a 
      significant benefit to task accuracy. Our results showed that switch trials 
      recruited a broader activity map than stay trials, including regions of the DMN, 
      the MDC, and task-positive networks such as visual, somatomotor, dorsal, 
      salience/ventral attention networks. More sequentially predictable trials 
      recruited increased activity in the somatomotor and salience/ventral attention 
      networks. Notably, changes in sequential and perceptual predictability, but not 
      spatial predictability, had significant effects on miFC. Increases in perceptual 
      predictability related to decreased miFC between control, visual, somatomotor, 
      and DMN regions, whereas increases in sequential predictability increased miFC 
      between regions in the same networks, as well as regions within ventral 
      attention/ salience, dorsal attention, limbic, and temporal parietal networks. 
      These results provide novel clues as to how DMN may contribute to executive task 
      performance. Specifically, the improved task performance, unique activity, and 
      increased miFC associated with increased sequential predictability suggest that 
      the DMN may coordinate more strongly with the MDC to generate a temporal schema 
      of upcoming task events, which may attenuate switching costs.
CI  - (c) 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
FAU - Kurtin, Danielle L
AU  - Kurtin DL
AUID- ORCID: 0000-0001-5368-6737
AD  - NeuroModulation Lab, Department of Psychology, Faculty of Health and Medical 
      Sciences, University of Surrey, Guildford, UK.
AD  - Department of Brain Sciences, Faculty of Medicine, Imperial College London, 
      London, UK.
FAU - Arana-Oiarbide, Garazi
AU  - Arana-Oiarbide G
AD  - Department of Brain Sciences, Faculty of Medicine, Imperial College London, 
      London, UK.
FAU - Lorenz, Romy
AU  - Lorenz R
AUID- ORCID: 0000-0002-7742-3162
AD  - MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
AD  - The Poldrack Lab, Stanford University, Stanford, California, USA.
AD  - Department of Neurophysics, Max-Planck Institute for Human Cognitive and Brain 
      Sciences, Leipzig, Germany.
FAU - Violante, Ines R
AU  - Violante IR
AUID- ORCID: 0000-0002-4787-2901
AD  - NeuroModulation Lab, Department of Psychology, Faculty of Health and Medical 
      Sciences, University of Surrey, Guildford, UK.
FAU - Hampshire, Adam
AU  - Hampshire A
AD  - Department of Brain Sciences, Faculty of Medicine, Imperial College London, 
      London, UK.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - BB/S008314/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - 209139/Z/17/Z/WT_/Wellcome Trust/United Kingdom
GR  - DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230720
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Humans
MH  - *Brain/diagnostic imaging/physiology
MH  - *Brain Mapping
MH  - Memory, Short-Term/physiology
MH  - Magnetic Resonance Imaging
MH  - Cerebral Cortex
MH  - Nerve Net/diagnostic imaging
PMC - PMC10502652
OTO - NOTNLM
OT  - default mode network
OT  - fMRI
OT  - functional connectivity
OT  - multiple demand network
OT  - mutual information
OT  - switching
OT  - temporal predictability
EDAT- 2023/07/20 19:14
MHDA- 2023/09/18 12:42
PMCR- 2023/07/20
CRDT- 2023/07/20 16:13
PHST- 2023/06/08 00:00 [revised]
PHST- 2023/01/29 00:00 [received]
PHST- 2023/07/05 00:00 [accepted]
PHST- 2023/09/18 12:42 [medline]
PHST- 2023/07/20 19:14 [pubmed]
PHST- 2023/07/20 16:13 [entrez]
PHST- 2023/07/20 00:00 [pmc-release]
AID - HBM26430 [pii]
AID - 10.1002/hbm.26430 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2023 Oct 15;44(15):5030-5046. doi: 10.1002/hbm.26430. Epub 2023 
      Jul 20.