PMID- 37473999
OWN - NLM
STAT- MEDLINE
DCOM- 20230807
LR  - 20230807
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 238
DP  - 2023 Nov 1
TI  - MPFC PV(+) interneurons are involved in the antidepressant effects of running 
      exercise but not fluoxetine therapy.
PG  - 109669
LID - S0028-3908(23)00259-9 [pii]
LID - 10.1016/j.neuropharm.2023.109669 [doi]
AB  - Depression is a complex psychiatric disorder. Previous studies have shown that 
      running exercise reverses depression-like behavior faster and more effectively 
      than fluoxetine therapy. GABAergic interneurons, including the PV(+) interneuron 
      subtype, in the medial prefrontal cortex (MPFC) are involved in pathological 
      changes of depression. It was unknown whether running exercise and fluoxetine 
      therapy reverse depression-like behavior via GABAergic interneurons or the PV(+) 
      interneurons subtype in MPFC. To address this issue, we subjected mice with 
      chronic unpredictable stress (CUS) to a 4-week running exercise or fluoxetine 
      therapy. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed 
      that running exercise enriched GABAergic synaptic pathways in the MPFC of 
      CUS-exposed mice. However, the number of PV(+) interneurons but not the total 
      number of GABAergic interneurons in the MPFC of CUS-exposed mice reversed by 
      running exercise, not fluoxetine therapy. Running exercise increased the relative 
      gene expression levels of the PV gene in the MPFC of CUS-exposed mice without 
      altering other subtypes of GABAergic interneurons. Moreover, running exercise and 
      fluoxetine therapy both significantly improved the length, area and volume of 
      dendrites and the spine morphology of PV(+) interneurons in the MPFC of mice 
      exposed to CUS. However, running exercise but not fluoxetine therapy improved the 
      dendritic complexity level of PV(+) interneurons in the MPFC of CUS-exposed mice. 
      In summary, the number and dendritic complexity level of PV(+) interneurons may 
      be important therapeutic targets for the mechanism by which running exercise 
      reverses depression-like behavior faster and more effectively than fluoxetine 
      therapy.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Qin, Lu
AU  - Qin L
AD  - Department of Histology and Embryology, School of Basic Medical Sciences, 
      Chongqing Medical University, Chongqing, 400016, PR China; Laboratory of Stem 
      Cells and Tissue Engineering, School of Basic Medical Sciences, Chongqing Medical 
      University, Chongqing, 400016, PR China.
FAU - Liang, Xin
AU  - Liang X
AD  - Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical 
      Sciences, Chongqing Medical University, Chongqing, 400016, PR China; Department 
      of Pathology, School of Basic Medical Sciences, Chongqing Medical University, 
      Chongqing, 400016, PR China.
FAU - Qi, Yingqiang
AU  - Qi Y
AD  - Institute of Life Science, Chongqing Medical University, Chongqing, 400016, PR 
      China.
FAU - Luo, Yanmin
AU  - Luo Y
AD  - Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical 
      Sciences, Chongqing Medical University, Chongqing, 400016, PR China; Department 
      of Physiology, School of Basic Medical Sciences, Chongqing Medical University, 
      Chongqing, 400016, PR China.
FAU - Xiao, Qian
AU  - Xiao Q
AD  - Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical 
      Sciences, Chongqing Medical University, Chongqing, 400016, PR China; Department 
      of Radioactive Medicine, School of Basic Medical Sciences, Chongqing Medical 
      University, Chongqing, 400016, PR China.
FAU - Huang, Dujuan
AU  - Huang D
AD  - Department of Histology and Embryology, School of Basic Medical Sciences, 
      Chongqing Medical University, Chongqing, 400016, PR China; Laboratory of Stem 
      Cells and Tissue Engineering, School of Basic Medical Sciences, Chongqing Medical 
      University, Chongqing, 400016, PR China.
FAU - Zhou, Chunni
AU  - Zhou C
AD  - Department of Histology and Embryology, School of Basic Medical Sciences, 
      Chongqing Medical University, Chongqing, 400016, PR China; Laboratory of Stem 
      Cells and Tissue Engineering, School of Basic Medical Sciences, Chongqing Medical 
      University, Chongqing, 400016, PR China.
FAU - Jiang, Lin
AU  - Jiang L
AD  - Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical 
      Sciences, Chongqing Medical University, Chongqing, 400016, PR China; Lab Teaching 
      & Management Center, Chongqing Medical University, Chongqing, 400016, PR China.
FAU - Zhou, Mei
AU  - Zhou M
AD  - Department of Histology and Embryology, School of Basic Medical Sciences, 
      Chongqing Medical University, Chongqing, 400016, PR China; Laboratory of Stem 
      Cells and Tissue Engineering, School of Basic Medical Sciences, Chongqing Medical 
      University, Chongqing, 400016, PR China.
FAU - Zhou, Yuning
AU  - Zhou Y
AD  - Department of Histology and Embryology, School of Basic Medical Sciences, 
      Chongqing Medical University, Chongqing, 400016, PR China; Laboratory of Stem 
      Cells and Tissue Engineering, School of Basic Medical Sciences, Chongqing Medical 
      University, Chongqing, 400016, PR China.
FAU - Tang, Jing
AU  - Tang J
AD  - Department of Histology and Embryology, School of Basic Medical Sciences, 
      Chongqing Medical University, Chongqing, 400016, PR China; Laboratory of Stem 
      Cells and Tissue Engineering, School of Basic Medical Sciences, Chongqing Medical 
      University, Chongqing, 400016, PR China. Electronic address: 710345845@qq.com.
FAU - Tang, Yong
AU  - Tang Y
AD  - Department of Histology and Embryology, School of Basic Medical Sciences, 
      Chongqing Medical University, Chongqing, 400016, PR China; Laboratory of Stem 
      Cells and Tissue Engineering, School of Basic Medical Sciences, Chongqing Medical 
      University, Chongqing, 400016, PR China. Electronic address: ytang062@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230719
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 01K63SUP8D (Fluoxetine)
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Fluoxetine/pharmacology/metabolism
MH  - Antidepressive Agents/pharmacology
MH  - Interneurons
MH  - Prefrontal Cortex
MH  - *Running
OTO - NOTNLM
OT  - Dendrite
OT  - Depression
OT  - Exercise
OT  - MPFC
OT  - PV(+) interneurons
OT  - Stereology
COIS- Declaration of competing interest The authors declare no conflicts of commercial 
      or financial relationships.
EDAT- 2023/07/21 01:12
MHDA- 2023/08/07 06:42
CRDT- 2023/07/20 19:27
PHST- 2023/04/06 00:00 [received]
PHST- 2023/07/14 00:00 [revised]
PHST- 2023/07/17 00:00 [accepted]
PHST- 2023/08/07 06:42 [medline]
PHST- 2023/07/21 01:12 [pubmed]
PHST- 2023/07/20 19:27 [entrez]
AID - S0028-3908(23)00259-9 [pii]
AID - 10.1016/j.neuropharm.2023.109669 [doi]
PST - ppublish
SO  - Neuropharmacology. 2023 Nov 1;238:109669. doi: 10.1016/j.neuropharm.2023.109669. 
      Epub 2023 Jul 19.