PMID- 37474519
OWN - NLM
STAT- MEDLINE
DCOM- 20230724
LR  - 20230725
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 14
IP  - 1
DP  - 2023 Jul 20
TI  - Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially 
      subjective reward valuation in macaques.
PG  - 4372
LID - 10.1038/s41467-023-40143-x [doi]
LID - 4372
AB  - The value of one's own reward is affected by the reward of others, serving as a 
      source for envy. However, it is not known which neural circuits mediate such 
      socially subjective value modulation. Here, we chemogenetically dissected the 
      circuit from the medial prefrontal cortex (MPFC) to the lateral hypothalamus (LH) 
      while male macaques were presented with visual stimuli that concurrently signaled 
      the prospects of one's own and others' rewards. We found that functional 
      disconnection between the MPFC and LH rendered animals significantly less 
      susceptible to others' but not one's own reward prospects. In parallel with this 
      behavioral change, inter-areal coordination, as indexed by coherence and Granger 
      causality, decreased primarily in the delta and theta bands. These findings 
      demonstrate that the MPFC-to-LH circuit plays a crucial role in carrying 
      information about upcoming other-rewards for subjective reward valuation in 
      social contexts.
CI  - (c) 2023. The Author(s).
FAU - Noritake, Atsushi
AU  - Noritake A
AUID- ORCID: 0000-0002-5081-6257
AD  - Division of Behavioral Development, Department of System Neuroscience, National 
      Institute for Physiological Sciences, National Institutes of Natural Sciences, 
      Okazaki, Japan.
AD  - Department of Physiological Sciences, School of Life Science, The Graduate 
      University for Advanced Studies (SOKENDAI), Hayama, Japan.
FAU - Ninomiya, Taihei
AU  - Ninomiya T
AUID- ORCID: 0000-0002-6098-9637
AD  - Division of Behavioral Development, Department of System Neuroscience, National 
      Institute for Physiological Sciences, National Institutes of Natural Sciences, 
      Okazaki, Japan.
AD  - Department of Physiological Sciences, School of Life Science, The Graduate 
      University for Advanced Studies (SOKENDAI), Hayama, Japan.
FAU - Kobayashi, Kenta
AU  - Kobayashi K
AUID- ORCID: 0000-0002-7389-3693
AD  - Department of Physiological Sciences, School of Life Science, The Graduate 
      University for Advanced Studies (SOKENDAI), Hayama, Japan.
AD  - Section of Viral Vector Development, National Institute for Physiological 
      Sciences, National Institutes of Natural Sciences, Okazaki, Japan.
FAU - Isoda, Masaki
AU  - Isoda M
AUID- ORCID: 0000-0002-5094-6254
AD  - Division of Behavioral Development, Department of System Neuroscience, National 
      Institute for Physiological Sciences, National Institutes of Natural Sciences, 
      Okazaki, Japan. isodam@nips.ac.jp.
AD  - Department of Physiological Sciences, School of Life Science, The Graduate 
      University for Advanced Studies (SOKENDAI), Hayama, Japan. isodam@nips.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230720
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
SB  - IM
MH  - Male
MH  - Animals
MH  - *Macaca
MH  - *Reward
MH  - Hypothalamus
MH  - Hypothalamic Area, Lateral
MH  - Prefrontal Cortex
PMC - PMC10359292
COIS- The authors declare no competing interests.
EDAT- 2023/07/21 01:12
MHDA- 2023/07/24 06:42
PMCR- 2023/07/20
CRDT- 2023/07/20 23:16
PHST- 2022/10/28 00:00 [received]
PHST- 2023/07/13 00:00 [accepted]
PHST- 2023/07/24 06:42 [medline]
PHST- 2023/07/21 01:12 [pubmed]
PHST- 2023/07/20 23:16 [entrez]
PHST- 2023/07/20 00:00 [pmc-release]
AID - 10.1038/s41467-023-40143-x [pii]
AID - 40143 [pii]
AID - 10.1038/s41467-023-40143-x [doi]
PST - epublish
SO  - Nat Commun. 2023 Jul 20;14(1):4372. doi: 10.1038/s41467-023-40143-x.